GB859727A - New phenthiazine derivatives - Google Patents
New phenthiazine derivativesInfo
- Publication number
- GB859727A GB859727A GB3452658A GB3452658A GB859727A GB 859727 A GB859727 A GB 859727A GB 3452658 A GB3452658 A GB 3452658A GB 3452658 A GB3452658 A GB 3452658A GB 859727 A GB859727 A GB 859727A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- carbon atoms
- general formula
- lower alkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0859727/IV(b)/1> and their acid addition and quaternary ammonium salts (wherein A is <FORM:0859727/IV(b)/2> X is a hydrogen or halogen atom or a lower alkyl, alkoxy or aryl group or a cyano, methylthio, methanesulphonyl, dimethylsulphamoyl or trifluoromethyl group; and one or more of the piperazine nuclear carbon atoms may bear a lower alkyl group), and the preparation thereof by: (1) reacting a compound of the general formula: <FORM:0859727/IV(b)/3> or an acid addition salt thereof with a morpholino carbonyl halide; and (2) reacting a compound of the general formula: <FORM:0859727/IV(b)/4> (wherein Z is a halogen atom) or an acid addition salt thereof with morpholine; also pharmaceutical compositions containing the products (see Group VI). Other general processes for making the compounds of the invention are disclosed in the Provisional Specification. The qualification "lower" means that the group in question has not more than four carbon atoms. 3-Chloro-10-[3- (4-chlorocarbonyl-1-piperazinyl) -propyl]-phenthiazine hydrochloride is made from 3-chloro-10-[3-(1-piperazinyl) propyl] phenthiazine and phosgene.ALSO:Pharmaceutical compositions comprise at least one compound of the general formula: <FORM:0859727/VI/1> N an acid addition salt with an inorganic or organic acid or quaternary ammonium salt thereof (wherein A is -(Clh)3- or -Clh- <FORM:0859727/VI/2> ; X is a hydrogen or halogen atom or a lower alkyl, alkoxy or acyl group or a cyano, methylthio, methanesulphonyl, dimethylsulphamyl or trifluoromethyl group, and one or more of the piperazine nuclear carbon atoms may bear a lower alkyl group) in association with a significant amount of a pharmaceutical carrier. They may be administered orally or parenterally; and be in the form of liquids or solids or any combination thereof. The qualification "lower" means that the group in question has not more than four carbon atoms.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3452658A GB859727A (en) | 1958-10-28 | 1958-10-28 | New phenthiazine derivatives |
FR805728A FR1297715A (en) | 1958-10-28 | 1959-09-22 | New phenothiazine derivatives and their preparation processes |
ES0252697A ES252697A1 (en) | 1958-10-28 | 1959-10-16 | New phenthiazine derivatives |
DES65494A DE1097997B (en) | 1958-10-28 | 1959-10-20 | Process for the preparation of phenthiazine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3452658A GB859727A (en) | 1958-10-28 | 1958-10-28 | New phenthiazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB859727A true GB859727A (en) | 1961-01-25 |
Family
ID=10366737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3452658A Expired GB859727A (en) | 1958-10-28 | 1958-10-28 | New phenthiazine derivatives |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1097997B (en) |
ES (1) | ES252697A1 (en) |
GB (1) | GB859727A (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE535922A (en) * | 1954-04-27 | |||
BE558008A (en) * | 1956-06-21 |
-
1958
- 1958-10-28 GB GB3452658A patent/GB859727A/en not_active Expired
-
1959
- 1959-10-16 ES ES0252697A patent/ES252697A1/en not_active Expired
- 1959-10-20 DE DES65494A patent/DE1097997B/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE1097997B (en) | 1961-01-26 |
ES252697A1 (en) | 1960-02-01 |
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