ES252697A1 - New phenthiazine derivatives - Google Patents

New phenthiazine derivatives

Info

Publication number
ES252697A1
ES252697A1 ES0252697A ES252697A ES252697A1 ES 252697 A1 ES252697 A1 ES 252697A1 ES 0252697 A ES0252697 A ES 0252697A ES 252697 A ES252697 A ES 252697A ES 252697 A1 ES252697 A1 ES 252697A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
general formula
lower alkyl
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0252697A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES252697A1 publication Critical patent/ES252697A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0859727/IV(b)/1> and their acid addition and quaternary ammonium salts (wherein A is <FORM:0859727/IV(b)/2> X is a hydrogen or halogen atom or a lower alkyl, alkoxy or aryl group or a cyano, methylthio, methanesulphonyl, dimethylsulphamoyl or trifluoromethyl group and one or more of the piperazine nuclear carbon atoms may bear a lower alkyl group), and the preparation thereof by: (1) reacting a compound of the general formula: <FORM:0859727/IV(b)/3> or an acid addition salt thereof with a morpholino carbonyl halide and (2) reacting a compound of the general formula: <FORM:0859727/IV(b)/4> (wherein Z is a halogen atom) or an acid addition salt thereof with morpholine also pharmaceutical compositions containing the products (see Group VI). Other general processes for making the compounds of the invention are disclosed in the Provisional Specification. The qualification "lower" means that the group in question has not more than four carbon atoms. 3-Chloro-10-[3- (4-chlorocarbonyl-1-piperazinyl) -propyl]-phenthiazine hydrochloride is made from 3-chloro-10-[3-(1-piperazinyl) propyl] phenthiazine and phosgene.ALSO:Pharmaceutical compositions comprise at least one compound of the general formula: <FORM:0859727/VI/1> N an acid addition salt with an inorganic or organic acid or quaternary ammonium salt thereof (wherein A is -(Clh)3- or -Clh- <FORM:0859727/VI/2> X is a hydrogen or halogen atom or a lower alkyl, alkoxy or acyl group or a cyano, methylthio, methanesulphonyl, dimethylsulphamyl or trifluoromethyl group, and one or more of the piperazine nuclear carbon atoms may bear a lower alkyl group) in association with a significant amount of a pharmaceutical carrier. They may be administered orally or parenterally and be in the form of liquids or solids or any combination thereof. The qualification "lower" means that the group in question has not more than four carbon atoms.
ES0252697A 1958-10-28 1959-10-16 New phenthiazine derivatives Expired ES252697A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3452658A GB859727A (en) 1958-10-28 1958-10-28 New phenthiazine derivatives

Publications (1)

Publication Number Publication Date
ES252697A1 true ES252697A1 (en) 1960-02-01

Family

ID=10366737

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0252697A Expired ES252697A1 (en) 1958-10-28 1959-10-16 New phenthiazine derivatives

Country Status (3)

Country Link
DE (1) DE1097997B (en)
ES (1) ES252697A1 (en)
GB (1) GB859727A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL89749C (en) * 1954-04-27
BE558008A (en) * 1956-06-21

Also Published As

Publication number Publication date
GB859727A (en) 1961-01-25
DE1097997B (en) 1961-01-26

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