GB774883A - Phenthiazine derivatives - Google Patents

Phenthiazine derivatives

Info

Publication number
GB774883A
GB774883A GB17971/55A GB1797155A GB774883A GB 774883 A GB774883 A GB 774883A GB 17971/55 A GB17971/55 A GB 17971/55A GB 1797155 A GB1797155 A GB 1797155A GB 774883 A GB774883 A GB 774883A
Authority
GB
United Kingdom
Prior art keywords
atom
methyl
derivatives
quaternary ammonium
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17971/55A
Inventor
Robert Michel Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB774883A publication Critical patent/GB774883A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises phenthiazine derivatives of the formula: <FORM:0774883/IV(b)/1> and their acid addition salts and quaternary ammonium derivatives in which the -CH2-bridge is directly connected to a ring carbon atom of the piperidine nucleus, X represents a halogen (preferably chlorine) atom or an alkyl or alkoxy group containing not more than 4 carbon atoms or a phenyl or phenoxy group and R represents a hydrogen atom or an alkyl group containing not more than 4 carbon atoms or a benzyl group. Such compounds are obtained by the method of Specification 774,882. Preferred for therapeutic purposes are the hydrohalides and the quaternary ammonium salts. Bases specifically described are 3 - chloro -, 3-methyl asnd 3-methoxy-10-(1-methyl-3-piperidyl)-methylphenthiazines.
GB17971/55A 1954-06-21 1954-06-21 Phenthiazine derivatives Expired GB774883A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB333362X 1954-06-21
GB160655X 1955-06-16

Publications (1)

Publication Number Publication Date
GB774883A true GB774883A (en) 1957-05-15

Family

ID=26251762

Family Applications (2)

Application Number Title Priority Date Filing Date
GB18213/54A Expired GB774882A (en) 1954-06-21 1954-06-21 Improvements in or relating to phenthiazine derivatives
GB17971/55A Expired GB774883A (en) 1954-06-21 1954-06-21 Phenthiazine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB18213/54A Expired GB774882A (en) 1954-06-21 1954-06-21 Improvements in or relating to phenthiazine derivatives

Country Status (4)

Country Link
CH (1) CH333362A (en)
DE (1) DE1052403B (en)
FR (1) FR1171946A (en)
GB (2) GB774882A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100635B (en) * 1958-04-22 1961-03-02 Rhone Poulenc Sa Process for the preparation of phenthiazine derivatives
DE1092476B (en) * 1958-04-24 1960-11-10 Rhone Poulenc Sa Process for the preparation of phenthiazine derivatives
NL244514A (en) * 1958-10-21
GB8912303D0 (en) * 1989-05-27 1989-07-12 Pfizer Ltd Therapeutic agents
CA2843338C (en) 2011-08-02 2020-08-25 Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Selective inhibition of malt1 protease by phenothiazine derivatives
US20240217961A1 (en) * 2021-03-05 2024-07-04 Monopteros Therapeutics, Inc. (S)-Mepazine Salt Forms, Process of Preparing, and Formulations Thereof

Also Published As

Publication number Publication date
DE1052403B (en) 1959-03-12
GB774882A (en) 1957-05-15
CH333362A (en) 1958-10-15
FR1171946A (en) 1959-02-03

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