GB850424A - 6-methyl steroid compounds - Google Patents

6-methyl steroid compounds

Info

Publication number
GB850424A
GB850424A GB2135059A GB2135059A GB850424A GB 850424 A GB850424 A GB 850424A GB 2135059 A GB2135059 A GB 2135059A GB 2135059 A GB2135059 A GB 2135059A GB 850424 A GB850424 A GB 850424A
Authority
GB
United Kingdom
Prior art keywords
dione
methyl
hours
organic solvent
inert organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2135059A
Inventor
Vladimir Petrow
David Morton Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BDH Chemicals Ltd
Original Assignee
BDH Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH7512359A priority Critical patent/CH377810A/en
Application filed by BDH Chemicals Ltd filed Critical BDH Chemicals Ltd
Priority to GB2135059A priority patent/GB850424A/en
Publication of GB850424A publication Critical patent/GB850424A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 6a : dimethylpregna-4 : 16-dien-3 : 20-dione and 6a -methyl-16a : 17a -(21 : 31-diazacyclopent-21-eno)-pregn-4 ene-3 : 20-dione, and the preparation of the former by reacting 6a -methyl-pregna-4 : 16-diene-3 : 20-dione with diazomethane to yield the diaza compound and then thermally decomposing this. The first process is preferably performed in an inert organic solvent such as diethyl ether and the reaction mixture allowed to stand at room temperature for periods of 16 to 40 hours. The thermal decomposition is advantageously performed at reflux temperature in an inert organic solvent of b.p. approximately the same as the m.p. of the diaza compound for a duration of 3 to 5 hours, suitable solvents being dibutyl ether, p-cymene and ethylene glycol. An example is given.
GB2135059A 1958-07-09 1959-07-09 6-methyl steroid compounds Expired GB850424A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH7512359A CH377810A (en) 1958-07-09 1959-06-30 Process for the preparation of 6a, 16-dimethylpregna-4,16-diene-3,20-dione
GB2135059A GB850424A (en) 1959-07-09 1959-07-09 6-methyl steroid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2135059A GB850424A (en) 1959-07-09 1959-07-09 6-methyl steroid compounds

Publications (1)

Publication Number Publication Date
GB850424A true GB850424A (en) 1960-10-05

Family

ID=10161410

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2135059A Expired GB850424A (en) 1958-07-09 1959-07-09 6-methyl steroid compounds

Country Status (1)

Country Link
GB (1) GB850424A (en)

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