GB846521A - Fermentation process for the preparation of tryptophane - Google Patents

Fermentation process for the preparation of tryptophane

Info

Publication number
GB846521A
GB846521A GB9681/58A GB968158A GB846521A GB 846521 A GB846521 A GB 846521A GB 9681/58 A GB9681/58 A GB 9681/58A GB 968158 A GB968158 A GB 968158A GB 846521 A GB846521 A GB 846521A
Authority
GB
United Kingdom
Prior art keywords
tryptophane
indole
nutrient medium
serine
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9681/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB846521A publication Critical patent/GB846521A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Tryptophane is prepared by contacting a tryptophane auxotroph of E. coli in a nutrient medium with the compounds indole and serine. The tryptophane auxotroph fermentation inoculum is prepared by fermentation of the microorganism in a nutrient medium containing one or more of indole, tryptophane and anthranilic acid. After adjusting the pH to between 7,4 and 8,5 indole and serine are added and the broth is gently mixed and allowed to stand at 25 to 40 DEG C. for from 8 to 24 hours. Best results are obtained under stationary conditions. The nutrient medium may contain a carbohydrate source such as glucose, mannitol, sorbitol or glycerol of which one or more may be used. One or more organic acids such as acetic, citric, succinic, fumaric and glutamic may be present.
GB9681/58A 1957-05-02 1958-03-26 Fermentation process for the preparation of tryptophane Expired GB846521A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US846521XA 1957-05-02 1957-05-02

Publications (1)

Publication Number Publication Date
GB846521A true GB846521A (en) 1960-08-31

Family

ID=22186330

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9681/58A Expired GB846521A (en) 1957-05-02 1958-03-26 Fermentation process for the preparation of tryptophane

Country Status (1)

Country Link
GB (1) GB846521A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385762A (en) * 1964-06-29 1968-05-28 Chugai Pharmaceutical Co Ltd Process for the production of l-tryptophan by fermentation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385762A (en) * 1964-06-29 1968-05-28 Chugai Pharmaceutical Co Ltd Process for the production of l-tryptophan by fermentation

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