GB820267A - The production of diaminopimelic acid by a fermentation process - Google Patents

The production of diaminopimelic acid by a fermentation process

Info

Publication number
GB820267A
GB820267A GB32687/56A GB3268756A GB820267A GB 820267 A GB820267 A GB 820267A GB 32687/56 A GB32687/56 A GB 32687/56A GB 3268756 A GB3268756 A GB 3268756A GB 820267 A GB820267 A GB 820267A
Authority
GB
United Kingdom
Prior art keywords
fermentation
diaminopimelic acid
lysine
referred
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32687/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB820267A publication Critical patent/GB820267A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Abstract

Diaminopimelic acid is prepared by the submerged aerobic fermentation of a mutant of Escherichia coli which requires lysine for its growth and lacks the enzyme diaminopimelic acid decarboxylase, the fermentation being carried out on a nutrient medium containing a source of lysine, the pH of which is maintained near neutrality. A suitable organism is E. coli ATCC 12408. Neutrality is maintained by the addition of alkali, e.g. sodium hydroxide, potassium hydroxide, or preferably ammonium hydroxide, or urea; towards the end of the fermentation the pH tends to rise, and is adjusted with sulphuric acid. The medium may contain glycerol, mannitol, and/or cornsteep liquor. The fermentation is preferably conducted at about 28 DEG C. for about three days. Specification 820,268 is referred to.ALSO:Diaminopimelic acid may be used as a supplement in the feeding of poultry, where it takes the place of lysine. Specification 820,268 [Group IV(b)] is referred to.
GB32687/56A 1955-12-09 1956-10-26 The production of diaminopimelic acid by a fermentation process Expired GB820267A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US820267XA 1955-12-09 1955-12-09

Publications (1)

Publication Number Publication Date
GB820267A true GB820267A (en) 1959-09-16

Family

ID=22168570

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32687/56A Expired GB820267A (en) 1955-12-09 1956-10-26 The production of diaminopimelic acid by a fermentation process

Country Status (1)

Country Link
GB (1) GB820267A (en)

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