GB849370A - The production of l-lysine by fermentation process - Google Patents

The production of l-lysine by fermentation process

Info

Publication number
GB849370A
GB849370A GB22134/57A GB2213457A GB849370A GB 849370 A GB849370 A GB 849370A GB 22134/57 A GB22134/57 A GB 22134/57A GB 2213457 A GB2213457 A GB 2213457A GB 849370 A GB849370 A GB 849370A
Authority
GB
United Kingdom
Prior art keywords
lysine
source
initially
conducted under
organism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22134/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB849370A publication Critical patent/GB849370A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A process for the preparation of L-lysine comprises fermenting, with the sole organism employed being a mutant of Escherichia coli which initially requires L-lysine for growth, a nutrient medium containing a source of carbohydrate (e.g. crude molasses or dextrose), a source of trace minerals (e.g., MgSO4) and a source of nitrogen (e.g. ammonium hydrogen phosphate), and initially containing 0,1-0,5 g. of L-lysine per litre, the fermentation being initially conducted under submerged aerobic conditions for 36-60 hours (whereby diamino pimelic acid is accumulated in the fermentation broth), and then, after adjusting the pH to 7,2-8,2 and rupturing the cell wall of the organism, e.g. by treating the mixture with toluene, continuing the reaction for at least 12 additional hours, so converting the diaminopimelic acid to lysine. The second stage is preferably conducted under anaerobic conditions. The lysine may be adsorbed on a strong cation exchange resin and eluted with dilute alkali. Specifications 820,267 and 820,268 are referred to.
GB22134/57A 1956-10-18 1957-07-12 The production of l-lysine by fermentation process Expired GB849370A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US849370XA 1956-10-18 1956-10-18

Publications (1)

Publication Number Publication Date
GB849370A true GB849370A (en) 1960-09-28

Family

ID=22188145

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22134/57A Expired GB849370A (en) 1956-10-18 1957-07-12 The production of l-lysine by fermentation process

Country Status (1)

Country Link
GB (1) GB849370A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1331220A3 (en) * 2002-01-25 2003-09-17 Ajinomoto Co., Inc. Dry granulated product containing-L-lysine as main component

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1331220A3 (en) * 2002-01-25 2003-09-17 Ajinomoto Co., Inc. Dry granulated product containing-L-lysine as main component
US7416740B2 (en) 2002-01-25 2008-08-26 Ajinomoto Co., Inc. Dry granulated product containing L-lysine as main component
US7883878B2 (en) 2002-01-25 2011-02-08 Ajinomoto Co., Inc. Dry granulated product containing L-lysine as main component

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