GB836724A - Steroid compounds and the preparation thereof - Google Patents

Steroid compounds and the preparation thereof

Info

Publication number
GB836724A
GB836724A GB31584/56A GB3158456A GB836724A GB 836724 A GB836724 A GB 836724A GB 31584/56 A GB31584/56 A GB 31584/56A GB 3158456 A GB3158456 A GB 3158456A GB 836724 A GB836724 A GB 836724A
Authority
GB
United Kingdom
Prior art keywords
acid ester
pregnadiene
acid
preparation
comptroller
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31584/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB836724A publication Critical patent/GB836724A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises D 1,4-pregnadiene-11b ,21-diol-3,20-dione, or an acid ester thereof, or a salt of such an acid ester and a process for converting D 4-pregnene-21-ol-3,11,20-trione to the corresponding D 1,4 - steroid compound, which comprises subjecting the starting material to the oxidizing activity of an organism of the genus Mycobacterium, e.g. M. phlei. The 21-hydroxy group may be esterified with hydrocarbon mono- or dicarboxylic acids, e.g. by means of the acid anhydride, acyl halide or the acid itself. The esters with dicarboxylic acids form salts with alkali. Examples describe the preparation of 1,4-pregnadiene-21-ol-3,11,20-trione and the acetate, propionate, butyrate, hemi-succinate, hemiphthalate, benzoate and valerate thereof, and salts of the acid esters. Reference has been directed by the Comptroller to Specification 807,227.ALSO:A therapeutic composition comprises D 1,4-pregnadiene - 11b ,21 - diol - 3,20 - dione, or an acid ester thereof, or a salt of such an acid ester incorporated in a suitable carrier therefore. Reference has been directed by the Comptroller to Specification 807,227.
GB31584/56A 1955-12-08 1956-10-17 Steroid compounds and the preparation thereof Expired GB836724A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US836724XA 1955-12-08 1955-12-08

Publications (1)

Publication Number Publication Date
GB836724A true GB836724A (en) 1960-06-09

Family

ID=22179934

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31584/56A Expired GB836724A (en) 1955-12-08 1956-10-17 Steroid compounds and the preparation thereof

Country Status (1)

Country Link
GB (1) GB836724A (en)

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