GB718640A - Cyclopentanophenanthrene compounds and a process for the manufacture thereof - Google Patents

Cyclopentanophenanthrene compounds and a process for the manufacture thereof

Info

Publication number
GB718640A
GB718640A GB11010/52A GB1101052A GB718640A GB 718640 A GB718640 A GB 718640A GB 11010/52 A GB11010/52 A GB 11010/52A GB 1101052 A GB1101052 A GB 1101052A GB 718640 A GB718640 A GB 718640A
Authority
GB
United Kingdom
Prior art keywords
allopregnan
triol
dione
carboxylic acid
aliphatic carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11010/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex SA
Original Assignee
Syntex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex SA filed Critical Syntex SA
Publication of GB718640A publication Critical patent/GB718640A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises 21-aliphatic carboxylic acid esters and 3,21-dialiphatic carboxylic acid esters of allopregnan-3b ,17a ,21-triol-11,20-dione, a process for the preparation of the 21-monoesters by hydrogenating the corresponding 21-esters of allopregnan-17a ,21-diol-3,11,20-trione in the presence of Raney nickel catalyst, and a process for the preparation of the 3,21-diesters by acylating the 21-monoesters with an aliphatic carboxylic acid anhydride. The ester radicals may be derived from aliphatic carboxylic acids containing not more than 6 carbon atoms. The reduction is preferably carried out in an inert solvent, e.g. a mixture of dioxane and alcohol, by shaking with Raney nickel in an atmosphere of hydrogen. The esterification step is preferably carried out with an esterification catalyst, e.g. pyridine. In the example, allopregnan - 3b ,17a ,21 - triol - 11,20 - dione 21 - acetate and allopregnan - 3b ,17a ,21 - triol - 11,20 - dione 3,21 - diacetate are prepared. Specification 712,058 is referred to.
GB11010/52A 1951-05-09 1952-05-01 Cyclopentanophenanthrene compounds and a process for the manufacture thereof Expired GB718640A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US718640XA 1951-05-09 1951-05-09

Publications (1)

Publication Number Publication Date
GB718640A true GB718640A (en) 1954-11-17

Family

ID=22104091

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11010/52A Expired GB718640A (en) 1951-05-09 1952-05-01 Cyclopentanophenanthrene compounds and a process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB718640A (en)

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