GB821192A - Improvements in the production of derivatives of beta-hydroxy-(beta)-halogeno-diethylamine - Google Patents

Improvements in the production of derivatives of beta-hydroxy-(beta)-halogeno-diethylamine

Info

Publication number
GB821192A
GB821192A GB2720657A GB2720657A GB821192A GB 821192 A GB821192 A GB 821192A GB 2720657 A GB2720657 A GB 2720657A GB 2720657 A GB2720657 A GB 2720657A GB 821192 A GB821192 A GB 821192A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
butene
beta
ethyleneimino
cyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2720657A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Badische Anilin and Sodafabrik AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE, Badische Anilin and Sodafabrik AG filed Critical BASF SE
Publication of GB821192A publication Critical patent/GB821192A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds having the skeletal structure <FORM:0821192/IV (a)/1> (X being a halogen) are prepared by treating compounds having the skeletal structure <FORM:0821192/IV (a)/2> with aqueous halogen hydracid, preferably with cooling. In examples: (1) and (2) 1-ethyleneimino-2-hydroxy-butene-(3) with 2N hydrochloric acid at room temperature or at 50 DEG C., or with 0.1N acid at 36 DEG to 37 DEG C., gives 1-(betachloro) - ethylamino - 2 - hydroxy - butene - (3)hydrochloride; (3) 1-(C-methyl)-ethyleneimino - 2 - hydroxy - butene - (3) with 2N hydrochloric acid at 0 DEG to 5 DEG C. or at 40 DEG C. gives 1 - (beta - chloro) - isopropylamino - 2 - hydroxy - butene - (3); and (4) 1 - (N) - ethyleneimino - 2 - vinyl - 2 - hydroxy - cyclohexane with 0.5N hydrochloric acid at 50 DEG C. gives 1-(betachloro) - ethylamino - 2 - vinyl - 2 - hydroxy - cyclohexane. Reference is also made to the use of 1 - ethylene - imino - 2 - hydroxy - 2 - methylbutene-(3) and to the reaction products of ethylene imine or the C-substitution products thereof such as the C-methyl, C-ethyl or C-propyl derivatives or of spirocyclohexylethylene-imines with any epoxy-(1 : 2)-alkene-(3 : 4), specifically isoprene oxide, 1 : 2-epoxyD 3 - cyclohexene, 1 - vinyl - epoxy - (1 : 2) - cyclohexane, epoxy - (1 : 2) - cyclo - octene - - (3 : 4) and styrene oxide, as starting materials suitable for use in the process of the invention. Reference is also made to the use of hydrogen fluoride, hydrogen bromide or hydrogen iodide in the process of the invention. Specification 783,728 is referred to.ALSO:Pharmaceutical compositions comprise compounds having the skeletal structure <FORM:0821192/VI/1> (X being a halogen) in admixture with water, buffer substances or flavouring agents.
GB2720657A 1956-09-05 1957-08-29 Improvements in the production of derivatives of beta-hydroxy-(beta)-halogeno-diethylamine Expired GB821192A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB41640A DE1064500B (en) 1956-09-05 1956-09-05 Process for the preparation of 1- [beta-chloroethylamino] -2-hydroxy-alkenene (3) or the derivatives substituted on the carbon atom by hydrocarbon radicals

Publications (1)

Publication Number Publication Date
GB821192A true GB821192A (en) 1959-09-30

Family

ID=6966465

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2720657A Expired GB821192A (en) 1956-09-05 1957-08-29 Improvements in the production of derivatives of beta-hydroxy-(beta)-halogeno-diethylamine

Country Status (4)

Country Link
CH (1) CH360681A (en)
DE (1) DE1064500B (en)
FR (1) FR1215544A (en)
GB (1) GB821192A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4034788A1 (en) * 1990-11-02 1992-05-07 Basf Ag METHOD FOR PRODUCING NICKELED MOLDED PARTS

Also Published As

Publication number Publication date
FR1215544A (en) 1960-04-19
CH360681A (en) 1962-03-15
DE1064500B (en) 1959-09-03

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