GB810212A - A method for the preparation of aminoacyl anilides - Google Patents

A method for the preparation of aminoacyl anilides

Info

Publication number
GB810212A
GB810212A GB31665/55A GB3166555A GB810212A GB 810212 A GB810212 A GB 810212A GB 31665/55 A GB31665/55 A GB 31665/55A GB 3166555 A GB3166555 A GB 3166555A GB 810212 A GB810212 A GB 810212A
Authority
GB
United Kingdom
Prior art keywords
betaine
formula
triethyl
sodium hydroxide
anilides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31665/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of GB810212A publication Critical patent/GB810212A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Aminoacyl anilides of the general formula <FORM:0810212/IV (b)/1> (wherein R1, R2 and R4 are methyl or ethyl and R3 is hydrogen or methyl) are prepared by decomposing at an elevated temperature a quaternary salt which has a cation of the formula <FORM:0810212/IV (b)/2> (wherein R4 is identical with R5). This process may be combined with the formation of the starting material in situ by reacting an isocyanate of the formula <FORM:0810212/IV (b)/3> with a betaine salt having a cation of the formula <FORM:0810212/IV (b)/4> in the presence of a tertiary amine. The first of the above processes is preferably effected in presence of alkali, e.g. aqueous sodium hydroxide or sodium alcoholate, or in vacuo. In examples: (1) triethyl betaine-2 : 6-dimethylanilide-bromide is heated with sodium hydroxide solution to yield o -diethylamino-acetoxylidide-2 : 6; (2) sodium in butanol replaces the sodium hydroxide of (1); (3) triethyl betaine hydrogen sulphate and 2 : 6-dimethyl-phenyl isocyanate are refluxed in pyridine and, after removal of the pyridine, the residue is treated as in (1); (4) triethyl betaine-2 : 6-dimethylanilide-chloride is heated in vacuo to yield the product of (1). Specification 793,201 is referred to.
GB31665/55A 1954-11-11 1955-11-04 A method for the preparation of aminoacyl anilides Expired GB810212A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE810212X 1954-11-11

Publications (1)

Publication Number Publication Date
GB810212A true GB810212A (en) 1959-03-11

Family

ID=6724099

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31665/55A Expired GB810212A (en) 1954-11-11 1955-11-04 A method for the preparation of aminoacyl anilides

Country Status (1)

Country Link
GB (1) GB810212A (en)

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