GB763783A - Novel barbituric acid derivatives and a process for the preparation thereof - Google Patents

Novel barbituric acid derivatives and a process for the preparation thereof

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Publication number
GB763783A
GB763783A GB1770/55A GB177055A GB763783A GB 763783 A GB763783 A GB 763783A GB 1770/55 A GB1770/55 A GB 1770/55A GB 177055 A GB177055 A GB 177055A GB 763783 A GB763783 A GB 763783A
Authority
GB
United Kingdom
Prior art keywords
dimethyl
isopropyl
barbituric acid
preparation
dicarbalkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1770/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB763783A publication Critical patent/GB763783A/en
Expired legal-status Critical Current

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

The invention comprises 6-isopropyl-3,4-dimethyl - spiro - [cyclohexane - 1,51 - barbituric acid] and its salts, and its preparation by heating 2,3-dimethyl-butadiene with isobutylidenemalonic acid dialkyl ester, catalytically reducing the resulting 1,1 - dicarbalkoxy - 3,4 - dimethyl - 6 - isopropyl - cyclohexene - (3), heating the thus formed 1,1-dicarbalkoxy-3,4-dimethyl - 6 - isopropyl - cyclohexane with urea in the presence of an alkali metal alkoxide such as sodium ethoxide, and isolating the product by acidification with a weak acid. The salts are produced by reacting the barbituric acid derivative with an alkali metal hydroxide, an alkaline earth metal hydroxide, ammonium hydroxide or a basic amine such as diethylamine, diethanolamine, ethylene diamine, N : N-diethyl-ethylene diamine or methyl-glucamine. An example is given and the sodium salt of the product is prepared.
GB1770/55A 1954-01-25 1955-01-20 Novel barbituric acid derivatives and a process for the preparation thereof Expired GB763783A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US763783XA 1954-01-25 1954-01-25

Publications (1)

Publication Number Publication Date
GB763783A true GB763783A (en) 1956-12-19

Family

ID=22131622

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1770/55A Expired GB763783A (en) 1954-01-25 1955-01-20 Novel barbituric acid derivatives and a process for the preparation thereof

Country Status (1)

Country Link
GB (1) GB763783A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105315216A (en) * 2015-11-19 2016-02-10 中国农业大学 Barbituric acid-cyclohexene spiro compounds and preparation methods thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105315216A (en) * 2015-11-19 2016-02-10 中国农业大学 Barbituric acid-cyclohexene spiro compounds and preparation methods thereof

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