GB744020A - Anhydrotetracycline and acid addition salts thereof - Google Patents

Anhydrotetracycline and acid addition salts thereof

Info

Publication number
GB744020A
GB744020A GB23549/53A GB2354953A GB744020A GB 744020 A GB744020 A GB 744020A GB 23549/53 A GB23549/53 A GB 23549/53A GB 2354953 A GB2354953 A GB 2354953A GB 744020 A GB744020 A GB 744020A
Authority
GB
United Kingdom
Prior art keywords
anhydrotetracycline
addition salts
acid
acid addition
hydriodic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23549/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB744020A publication Critical patent/GB744020A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Anhydrotetracycline is prepared by treating chlortetracycline or anhydrochlortetracycline (see Specification 744,019), or acid addition salts thereof, with hydriodic acid. Aqueous solutions containing up to 57 per cent hydriodic acid may be used, 48 per cent acid being preferred. The reaction temperature is up to 100 DEG C. At the higher temperatures red phosphorus is preferably added to remove free iodine liberated during the reaction. Anhydrotetracycline may be crystallized from ethyl alcohol. It melts at 224 DEG to 226 DEG C. and [a ]D25 DEG = +24 DEG (in 2-ethoxyethanol). Acid addition salts specified are those with hydrochloric, hydriodic, hydrobromic and acetic acids.
GB23549/53A 1952-10-11 1953-08-26 Anhydrotetracycline and acid addition salts thereof Expired GB744020A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US744020XA 1952-10-11 1952-10-11

Publications (1)

Publication Number Publication Date
GB744020A true GB744020A (en) 1956-01-25

Family

ID=22119370

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23549/53A Expired GB744020A (en) 1952-10-11 1953-08-26 Anhydrotetracycline and acid addition salts thereof

Country Status (1)

Country Link
GB (1) GB744020A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990426A (en) * 1957-07-01 1961-06-27 Bristol Myers Co Epimerization process for anhydrotetracycline

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990426A (en) * 1957-07-01 1961-06-27 Bristol Myers Co Epimerization process for anhydrotetracycline

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