GB847645A - Improvements in or relating to the manufacture of 5-nitro-furan derivatives - Google Patents

Improvements in or relating to the manufacture of 5-nitro-furan derivatives

Info

Publication number
GB847645A
GB847645A GB17656A GB17656A GB847645A GB 847645 A GB847645 A GB 847645A GB 17656 A GB17656 A GB 17656A GB 17656 A GB17656 A GB 17656A GB 847645 A GB847645 A GB 847645A
Authority
GB
United Kingdom
Prior art keywords
nitro
furfuraldehyde
semicarbazide
reaction mixture
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17656A
Inventor
Denis Eric Greensmith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to GB17656A priority Critical patent/GB847645A/en
Publication of GB847645A publication Critical patent/GB847645A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
    • C07D307/74—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by hydrazino or hydrazono or such substituted radicals
    • C07D307/76—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by hydrazino or hydrazono or such substituted radicals having carbonic acyl radicals or their thio or nitrogen analogues directly attached to the hydrazino or hydrazono radical, e.g. semicarbazides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

5-Nitro-2-furfuraldehyde semicarbazone is prepared by heating a reaction mixture containing 5-nitro-2-furfuraldehyde and semicarbazide, said semicarbazide being contained in a reaction solution resulting directly from the interaction of urea and hydrazine in aqueous solution. A strong acid is preferably present especially sulphuric or hydrochloric, although phosphoric or trichloracetic acids may be used. The 5-nitro-2-furfuraldehyde may be prepared in situ, preferably before admixture with the semicarbazide solution, by hydrolysis of 5-nitro-2-furfuraldehyde diacetate by heating with an acid, preferably a strong mineral acid, especially sulphuric. It is also preferred to have present in the reaction mixture an inert water-miscible solvent, such as ethanol, preferably in an amount sufficient to produce a homogenous initial reaction mixture. The product may be purified by washing with a hot solvent, e.g. ethanol, capable of dissolving 5-nitro-2-furfuraldehyde or the diacetate thereof.
GB17656A 1956-01-03 1956-01-03 Improvements in or relating to the manufacture of 5-nitro-furan derivatives Expired GB847645A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB17656A GB847645A (en) 1956-01-03 1956-01-03 Improvements in or relating to the manufacture of 5-nitro-furan derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17656A GB847645A (en) 1956-01-03 1956-01-03 Improvements in or relating to the manufacture of 5-nitro-furan derivatives

Publications (1)

Publication Number Publication Date
GB847645A true GB847645A (en) 1960-09-14

Family

ID=9699754

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17656A Expired GB847645A (en) 1956-01-03 1956-01-03 Improvements in or relating to the manufacture of 5-nitro-furan derivatives

Country Status (1)

Country Link
GB (1) GB847645A (en)

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