GB707337A - Manufacture of 1.4-dihydrazinophthalazines - Google Patents

Manufacture of 1.4-dihydrazinophthalazines

Info

Publication number
GB707337A
GB707337A GB7409/52A GB740952A GB707337A GB 707337 A GB707337 A GB 707337A GB 7409/52 A GB7409/52 A GB 7409/52A GB 740952 A GB740952 A GB 740952A GB 707337 A GB707337 A GB 707337A
Authority
GB
United Kingdom
Prior art keywords
reaction
mols
manufacture
addition
benzaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7409/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Farbwerke Mainkur AG filed Critical Cassella Farbwerke Mainkur AG
Publication of GB707337A publication Critical patent/GB707337A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises a process for the manufacture of 1 : 4-dihydrazino-phthalazines by treating 1 mol. of phthalic dinitrile or a nuclear substitution product thereof with at least 3 mols. of hydrazine. The reaction may be carried out with the addition of weak acids and at temperatures not exceeding 100 DEG C. In an example phthalic dinitrile is reacted with slightly more than 3 mols. of hydrazine hydrate in dioxane with the addition of acetic acid. The 1 : 4-dihydrazinophthalazine is converted into the following derivatives: di- and tri-acetyl derivatives (by reaction with acetic anhydride at 90 DEG and 130 DEG C.); phthalazine-1 : 4-diphenylhydrazone (by reaction with benzaldehyde); the dipyrazolone (by reaction with aceto-acetic ester; the dihydrazone (by-reaction with acetophenone); and the di-(o-nitrophenylhydrazone (by reaction with o-nitro benzaldehyde).
GB7409/52A 1951-03-21 1952-03-21 Manufacture of 1.4-dihydrazinophthalazines Expired GB707337A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE707337X 1951-03-21

Publications (1)

Publication Number Publication Date
GB707337A true GB707337A (en) 1954-04-14

Family

ID=6617359

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7409/52A Expired GB707337A (en) 1951-03-21 1952-03-21 Manufacture of 1.4-dihydrazinophthalazines

Country Status (1)

Country Link
GB (1) GB707337A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338591B2 (en) * 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338591B2 (en) * 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines

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