GB692630A - Improvements in or relating to substituted pteridines - Google Patents

Abstract

The invention comprises pteridines of the general formula <FORM:0692630/IV (b)/1> wherein Y and Y1 each represent the n-propyl radical or an alkyl or cycloalkyl radical containing from 4 to 8 carbon atoms or a benzyl radical, and a process for the preparation of the above compounds by condensing 2,4,5,6-tetraamino-pyrimidine, its acetate or bisulphite with an a -diketone of the general formula <FORM:0692630/IV (b)/2> where Y and Y1 have the above significance. The reaction may be carried out in an acid or an alkaline medium such as an alkali metal carbonate, for example, sodium hydrogen carbonate, or in the presence of an organic base such as piperidine. In the examples compounds of the above general formula are prepared wherein Y and Y1 each represent the n-butyl, n-amyl, iso-butyl, n-propyl, benzyl, sec-butyl, sec-amyl and cyclohexyl radical. Di-n-hexyl-2,4-diaminopteridine is also referred to. 4 - Hydroxy - 3,6 - dimethyloctan - 5 - one is prepared by reacting ethyl sec.-valerate and sodium, and treating the reaction product with sulphuric acid. By a similar method 5-hydroxy - 4,7 - dimethyldecan - 6 - one is prepared from ethyl sec.-caproate and 2-hydroxy-1,4 - dicyclohexylbutan - 3 - one is prepared from ethyl cyclohexylacetate. 3,6 - Dimethyloctan - 4,5 - dione, 4,7 - dimethyldecan - 5,6 - dione and 1,4 - dicyclhexylbutan-2,3-dione are prepared by oxidizing the corresponding hydroxy-ketone referred to above.