ES290324A1 - Procedure for the obtaining of new esteroid phosphoric esters (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new esteroid phosphoric esters (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES290324A1 ES290324A1 ES290324A ES290324A ES290324A1 ES 290324 A1 ES290324 A1 ES 290324A1 ES 290324 A ES290324 A ES 290324A ES 290324 A ES290324 A ES 290324A ES 290324 A1 ES290324 A1 ES 290324A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- hydrogen atom
- represent
- lower alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 alkyl radical Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- PYRNHKLYVVIIJV-UHFFFAOYSA-N 1-cyanoethyl dihydrogen phosphate Chemical compound N#CC(C)OP(O)(O)=O PYRNHKLYVVIIJV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Process for obtaining new phosphoric esters of steroids of the general formula: ** (See formula) ** wherein R represents a hydrogen atom and a β-hydroxyl radical, or R and R1 together represent an oxygen atom, X represents a hydrogen or halogen atom, X1 represents a hydrogen atom or a lower alkyl radical, Y represents a hydrogen atom or a methyl radical, Y1 represents a hydrogen atom, where Y and Y1 may represent, together, a union that participates in a double union in position -1,2, A and B represent hydrogen atoms or lower alkyl radicals, lower alkyloxyls, monocyclic aromatic, lower araliphatic or heterocyclic radicals, or A and B together represent a lower alkyl radical; as well as its salts with the metals and the organically usable amine functional compounds, characterized in that a compound of the general formula is reacted ** (See formula) ** wherein the symbols have the same significance as above, with the cyano-2 ethyl phosphate in the presence of a carbodiimide and a tertiary amine used as a solvent medium, operating at a temperature not exceeding substantially 50º, to form in the first place place the compound of formula ** (See formula) ** This compound (III) is then hydrolyzed by reaction of a dilute aqueous solution of earthy alkali metal or alkaline hydroxide, thus forming a phosphate salt (I) from which the compound (I) itself is finally separated, then, optionally, the compound (I) thus isolated is converted into the desired salts by applying the corresponding methods. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR905188A FR1369333A (en) | 1962-07-26 | 1962-07-26 | New Phosphoric Esters of Steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES290324A1 true ES290324A1 (en) | 1964-01-01 |
Family
ID=8784000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES290324A Expired ES290324A1 (en) | 1962-07-26 | 1963-07-26 | Procedure for the obtaining of new esteroid phosphoric esters (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT253140B (en) |
| BR (1) | BR6350905D0 (en) |
| CH (1) | CH419116A (en) |
| ES (1) | ES290324A1 (en) |
| FR (2) | FR1369333A (en) |
| GB (1) | GB1006782A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035766A1 (en) * | 1969-03-07 | 1970-12-24 | Fabric Antibiotique Sifa | Preparation of prenane derivs |
-
1962
- 1962-07-26 FR FR905188A patent/FR1369333A/en not_active Expired
- 1962-10-25 FR FR913404A patent/FR2298M/en active Active
-
1963
- 1963-07-18 BR BR150905/63A patent/BR6350905D0/en unknown
- 1963-07-25 GB GB29584/63A patent/GB1006782A/en not_active Expired
- 1963-07-25 AT AT596663A patent/AT253140B/en active
- 1963-07-26 ES ES290324A patent/ES290324A1/en not_active Expired
- 1963-07-26 CH CH932663A patent/CH419116A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR1369333A (en) | 1964-08-14 |
| FR2298M (en) | 1964-01-27 |
| AT253140B (en) | 1967-03-28 |
| BR6350905D0 (en) | 1973-07-17 |
| CH419116A (en) | 1966-08-31 |
| GB1006782A (en) | 1965-10-06 |
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