Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1661/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products LtdfiledCriticalRoche Products Ltd
Publication of GB657254ApublicationCriticalpatent/GB657254A/en
Folic acid is prepared by reacting in solution, 2 : 4 : 5 - triamino - 6 - hydroxy - pyrimidine, glycero - aldehyde - ditoluene - parasulphonic acid ester, para-aminobenzoyl-L(+)-glutamic acid and a salt of hydriodic acid. A suitable salt mentioned is potassium iodide. Acrolein is formed by the action of a salt of hydriodic acid on glyceraldehyde - ditoluene - para - L(+) - glutamic acid in the usual way so that in the reaction to form folic acid, acrolein or a ,b -diiodo-glyceraldehyde may be formed in situ, which then reacts with the triamino-hydroxy-pyrimidine and the aminobenzoyl-glutamic acid. The Specification as open to inspection under Sect. 91, refers to the use of any glyceroaldehyde di-toluene sulphonic acid ester for the above process. This subject-matter does not appear in the Specification as accepted.
GB1661/49A1948-03-011949-01-20Process for the manufacture of folic acid
ExpiredGB657254A
(en)
Procedure for the obtaining of alpha-gamma-dioxy-amidas of organic acid substituted or not replaced (Machine-translation by Google Translate, not legally binding)