GB653365A - Improvements in or relating to iodinated pyridone derivatives of carboxylic acids - Google Patents
Improvements in or relating to iodinated pyridone derivatives of carboxylic acidsInfo
- Publication number
- GB653365A GB653365A GB24895/48A GB2489548A GB653365A GB 653365 A GB653365 A GB 653365A GB 24895/48 A GB24895/48 A GB 24895/48A GB 2489548 A GB2489548 A GB 2489548A GB 653365 A GB653365 A GB 653365A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alpha
- iodinated
- pyridone
- hydrocarbon radical
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
Abstract
Iodinated pyridone derivatives of carboxylic acids of the general formula <FORM:0653365/IV (b)/1> wherein Y is a divalent aliphatic hydrocarbon radical containing from 5 to 9 carbon atoms, are prepared by heating 3,5-diiodo-4-pyridone with a halocarboxylic acid of the formula X-Y-COOH, wherein X is halogen and Y has the above significance, in the presence of an alkali metal hydroxide and then acidifying the reaction product. The desired iodinated pyridone derivatives may be of the formula <FORM:0653365/IV (b)/2> wherein R is an alkyl group containing from 4 to 8 carbon atoms. Salts of the iodinated pyridone derivatives may be formed with inorganic or organic bases, e.g. sodium hydroxide, diethanolamine or diethylamine. In the examples the following compounds are prepared: alpha - n - butyl-, alpha - n - amyl-, alpha-n-hexyl-, alpha-isoamyl-, alpha-n-heptyl-, alpha-n-octyl- and alpha-isobutyl-3,5-diiodo-4-oxo - 1 - pyridineacetic acids. Specifications 385,214 and 396,414 are referred to. The Specification as open to inspection under Sect. 91 refers to the preparation of compounds of the above general formula wherein Y represents any divalent hydrocarbon radical. This subject-matter does not appear in the Specification as accepted.ALSO:An internal radiopaque is obtained by dissolving an iodinated pyridone derivative of the general formula <FORM:0653365/VI/1> wherein Y is a divalent aliphatic hydrocarbon radical containing from 5 to 9 carbon atoms, in an aqueous solution of an equivalent amount of sodium hydroxide, diethylamine or diethanolamine. The Specification as open to inspection under Sect. 91, refers to internal radiopaque obtained as above but where Y represents any divalent hydrocarbon radical. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US653365XA | 1947-10-03 | 1947-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB653365A true GB653365A (en) | 1951-05-16 |
Family
ID=22062002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24895/48A Expired GB653365A (en) | 1947-10-03 | 1948-09-23 | Improvements in or relating to iodinated pyridone derivatives of carboxylic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB653365A (en) |
-
1948
- 1948-09-23 GB GB24895/48A patent/GB653365A/en not_active Expired
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