GB625727A - Improvements relating to therapeutic compositions and methods of making the same - Google Patents

Abstract

A cell stimulating composition for use in treating wounds and infections and for stimulating the growth of healthy tissues is prepared by distributing therapeutically effective amounts of chlorophyll in a carrier and incorporating therein a material so that the pH of the composition is 6.0 to 8.5. Preferably the composition should be buffered at this pH range. Chlorophylls of 15 per cent purity, preferably 70-90 per cent or more, may be used and chlorophyll derivatives such as chlorophyllide a and b, iron and copper phaeophytin, phaeophytin a and b, phactochlorin e and g and copper and iron complexes thereof, phaeophorbide a and b, isochloraphyllin a and b, chlorophyllin a and b, also sodium and potassium salts of any of the foregoing which contain acid hydrogens. The compositions comprise fluid, viscuns or solid preparations, containing water-soluble or water-insoluble chlorophylls, the latter being preferred for the less fluid preparations such as ointments, salves and the like of oily or fatty nature. Emulsions of chlorophyll or of chlorophyll dissolved in oil, may be prepared by the use of dispersing agents such as certain waxes, ursolic acid, glyceryl and glycol fatty acid esters, soaps such as sodium, magnesium, calcium and zinc oleates and alkali metal salts of sulphuric acid esters of long chain alcohols. More viscous materials may have as base materials one or more vegetable oils such as cottonseed, olive, linseed, soyabean and eucalyptus oils, liquid paraffin, lanolin, lard, aquaphor (eucerin), petrolatum, monolene (propylene glycol stearate), cholesterols, stearic and palmitic acids and other higher and lower fatty acids, their alcohols and esters thereof such as glyceryl stearate, palonitate and oleate. Fatty preparations containing varying amounts of water have as an essential constituent water absorbing materials such as lanolin and preferably, in addition, 5 to 10 per cent glycerine. Anhydrous preparations contain a buffering agent so that in contact with water or aqueous secretions during application to the body, the compositions will have the desired fat. Ointment bases containing free fatty acids are first treated with aqueous alkali e.g. solutions of sodium or potassium hydroxide or carbonate to saponify the fatty acids and then adjusted to the desired pH. Any therapeutically compatible non-irritant buffering agent may be used in these compositions e.g., a strong inorganic acid or base with an appropriate acetate, citrate, acid phosphate or phthalate, boric acid and sodium borate, and citrus pectin. The examples describe, inter alia, aqueous and oily compositions for injection.