KR20010025824A - Cosmetic compositions for the skin having pimples thereon - Google Patents

Abstract

PURPOSE: A cosmetic composition for acne skin is provided, which inhibits secretion of sebum without skin irritation, and improves keratinized skin due to acne by containing indole-3 complex composed of indole-3 acetic acid(formula), carbamide peroxide and α-hydroxy acid(AHA). CONSTITUTION: The cosmetic composition for acne skin is comprised of distilled water, 1.0-8.0 wt.% of glycerin, 1.0-8.0 wt.% of 1,3-butylene glycol, 0.05-0.2 wt.% of allantoin, 3.0-10.0 wt.% of ethanol, 0.01-0.2 wt.% of disodium ethylenediaminetetraacetate, 0.01-0.1 wt.% of carboxyvinylcellulose, 0.000 1-0.01 wt% of sodium hydroxide, 5.0-15.0 wt% of carbamide peroxide(which decreases bacteria by removing keratins), 0.0001-0.1 wt% of indole-3 acetic acid(which regenerates wounded skin), 0.2-1.0 wt% of α-hydroxy acid(AHA; which shows keratin-softening effect and moisturizing effect, cell-regeneration effect, wound-treatment effect), 0.02wt.% of paraoxybenzoic ester. The cosmetic composition for acne skin can be prepared into a gel or an emulsion type.

Description

Cosmetic compositions for acne skin {Cosmetic compositions for the skin having pimples thereon}

The present invention relates to a cosmetic composition for acne skin, and more particularly to the skin containing the indole-3 complex (Indole-3 complex) consisting of indole-3 acetic acid, carbamide peroxide and α-hydroxy acid The present invention relates to a cosmetic composition for acne skin, which can suppress sebum secretion and improve skin agglomerated by acne.

Acne vulgaris is a disease that causes inflammation of the pilosebaceous gland, which is a protrusion of the skin, and is naturally absurd but not purulent. Acne is a common problem in puberty, and many adults also suffer from acne. There are four types of acne seats: comedones (blackheads or whiteheads), papules, pustules, and cysts or nodules (sulfur, resorcinol, salicylic acid, Various preparations containing benzoyl peroxide, vitamin A, carbamide peroxide, antibiotics and the like are used for their treatment.

However, the acne-containing formulations containing the above-described preparations have some results in the treatment of acne, but have some problems in terms of effectiveness and side effects.

In other words, resorcinol is used in a small amount at a concentration of 1 to 2, there is a problem of forming a dark brown scab in people with slightly dark skin, and tetracycline-containing antibiotics have the potential of bleeding and photosensitization of resistant bacteria There is this.

On the other hand, although benzoyl peroxide is the most effective substance that can be used for acne, it is toxic, triggers boils, causes extreme dryness, itching, skin irritation, erythema, peeling or swelling of skin. have.

Accordingly, the present inventors have studied to provide a cosmetic composition that can suppress the secretion of sebum and improve the skin aggravated by acne without causing the above problems with the components used in conventional acne treatment. As a result, it has been found that the above object can be achieved and the present invention has been completed.

Accordingly, it is an object of the present invention to provide a cosmetic composition for acne skin that can suppress sebum secretion and improve skin aggravated by acne without irritation to the skin.

In order to achieve the above object, the cosmetic composition according to the present invention contains 0.0001 to 0.01 weight of indole-3 acetoxide, 5.0 to 15.0 weight of carbamide peroxide and 0.2 to 1.0 weight of α-hydroxy acid based on the total weight of the composition It features.

Hereinafter, the present invention will be described in more detail.

The cosmetic composition for acne skin of the present invention can improve acne without skin irritation by containing indole-3 acetic acid, carbamide peroxide and α-hydroxyacid. Moreover, the composition of the present invention can improve skin aroused by acne.

Indole-3 acetic acid used in the present invention was used as a conventional plant growth hormone as a compound represented by the following general formula (I), but in the present invention, when it is contained in cosmetics and applied to the skin, it is rapidly moved to an area without cells. It acts to move human fibroblasts. Thus, the migrated healthy cells can then divide at the normal rate of the cells as they effectively fill the low density space, thereby causing wound healing or skin growth and eventually improving skin exfoliated by acne.

(Ⅰ)

Indole-3 acetic acid in the present invention is used in an amount of 0.0001 ~ 0.1 weight based on the total weight of the cosmetic.

In addition, the carbamide peroxide used in the present invention is known to be used in the treatment of acne by reducing the bacteria causing acne by exfoliation and drying the esters or fatty acids in the skin, It is not as effective as benzoyl peroxide in treating acne. However, in the present invention, synergistic effect is obtained by use with indole-3 acetic acid and α-hydroxyacid. The amount of carbamide peroxide used is 5.0-15.0 weight based on the total weight of the composition.

In addition, the α-hydroxy acid (hereinafter referred to as 'AHA') used in the present invention is keratin softening and moisturizing effect, keratin exfoliation effect, cell regeneration effect, keratin turn-off cycle reduction effect, keratin layer thickness reduction effect, wound In order to achieve the above-mentioned effects by using cosmetics as a substance with known effects such as healing effects, in this case, alpha hydroxy acid has a small molecular weight and is easy to penetrate into the skin, causing skin irritation. There is a problem and its usage is limited. However, in the present invention, since the indole-3 acetic acid and the carbamide peroxide are used in combination, AHA may provide an effect even in a small amount. The amount of AHA used is 0.2 to 1.0 weight based on the total weight of the composition.

Although the type of AHA used in the present invention is not particularly limited, glycolic acid, lactic acid, nitric acid, lactic acid, tartaric acid, citric acid, glyceric acid, glucuronic acid, tatronic acid, manderic acid, ascorbic acid, pyruvic acid and the like Artificially synthesized AHAs and one or more of naturally produced AHAs are used.

Cosmetic composition of the present invention containing the above components is 1.0 to 8.0 weight of glycerin, 1.0 to 8.0 weight of 1,3-butylene glycol, 0.05 to 0.2 weight of allatoin, 3.0 to 10.0 weight of ethanol, 0.01 to 0.1 It may be formulated into a gel with a weight of carboxycellulose, 0.01 to 0.2 weight of ethylenediaminedetraacetic acid disodium, 0.0001 to 0.01 weight of sodium hydroxide, and may also be formulated in an emulsified form. In each formulation, in addition to the three active ingredients described above, it may further contain other ingredients that have proven beneficial effects on the skin. For example, allantoin may be prescribed to act as an anti-inflammatory agent and salicylic acid may be added as a supplemental acne treatment ingredient. The other ingredients are appropriately selected and blended by those skilled in the art according to the cosmetic formulation.

Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited only to these examples.

Raw material name Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Purified water Glycerin 1,3-butylene glycol Alantoin Ethanol Salicylic acid Paraoxybenzoic acid Ethylene ethylene diamine Tetra acetate disodium Carboxy vinyl cellulose Rhodium hydroxide Carbamide peroxide Indole-3 Acetic acid α-hydroxy acid benzoyl peroxide 75.1695.05.00.14.0-0.20.020.150.00110.00.010.35- 74.6695.05.00.14.00.50.20.020.150.00110.00.010.35- 84.6695.05.00.14.00.50.20.020.150.001-0.010.35- 75.035.05.00.14.00.50.20.020.15 ---- 10.0 α-hydroxyacid: a mixture of lactic acid, tartaric acid and citric acid

<Test Example 1> acne reduction effect

Acne reduction effect was measured with the gel of Example 1 and Comparative Examples 1 to 3. The measurement method was to evaluate the degree of acne over time according to the following evaluation criteria when three gels of 16 to 37 years old and two men of each gel were used and not used. 1 to Table 4 are shown.

<Evaluation Criteria>

score Icicle phenomenon 1 2 3 4 5 Acne scalp hemiform with clear whiteheads Acicular pustules and follicles (Follicles) with acicular acne that is clearly infected with papules Acne with enlarged globular acne with globular acne Spherical acne, after the infection of the acne, the general secondary formation, acne scars remain.

Example 1 Subject process Do not process Before treatment 2 weeks 4 Weeks 6 Weeks Before treatment 2 weeks 4 Weeks 6 Weeks One 2.0 2.0 1.0 0.0 2.0 2.0 2.0 2.0 2 3.0 3.0 2.0 1.0 3.0 3.0 3.0 3.0 3 2.0 2.0 1.0 0.0 2.0 2.0 2.0 2.0 4 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 5 1.0 1.0 0.0 0.0 1.0 1.0 1.0 1.0 Average 1.8 1.8 0.8 0.2 1.8 1.8 1.8 1.8 0.0 -55.6 -88.9

Comparative Example 1 Subject process Do not process Before treatment 2 weeks 4 Weeks 6 Weeks Before treatment 2 weeks 4 Weeks 6 Weeks One 3.0 2.0 1.0 1.0 3.0 3.0 3.0 3.0 2 2.0 1.0 1.0 1.0 2.0 2.0 2.0 2.0 3 2.0 1.0 1.0 1.0 2.0 2.0 2.0 2.0 4 2.0 2.0 1.9 1.0 1.0 1.0 1.0 1.0 5 3.0 3.0 2.0 2.0 3.0 3.0 3.0 3.0 Average 2.4 1.8 1.2 1.2 2.2 2.2 2.2 2,2 -25.0 -50.0 -50.0

Comparative Example 2 Subject process Do not process Before treatment 2 weeks 4 Weeks 6 Weeks Before treatment 2 weeks 4 Weeks 6 Weeks One 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 2 3.0 3.0 3.0 2.0 3.0 3.0 3.0 3.0 3 2.0 2.0 3.0 2.0 2.0 2.0 2.0 2.0 4 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 5 1.0 1.0 1.0 0.0 1.0 1.0 1.0 1.0 Average 2.0 2.0 2.0 1.6 2.0 2.0 2.0 2.0 0.0 0.0 -20.0

Comparative Example 3 Subject process Do not process Before treatment 2 weeks 4 Weeks 6 Weeks Before treatment 2 weeks 4 Weeks 6 Weeks One 2.0 2.0 1.0 1.0 2.0 2.0 2.0 2.0 2 2.0 2.0 1.0 1.0 2.0 2.0 2.0 2.0 3 2.0 2.0 1.0 1.0 2.0 2.0 2.0 2.0 4 2.0 2.0 1.0 0.0 2.0 2.0 2.0 2.0 5 2.0 2.0 1.0 1.0 2.0 2.0 2.0 2.0 Average 2.0 2.0 1.0 0.8 2.0 2.0 2.0 2.0 0.0 -50.0 -60.0

From Tables 1 to 4, it can be seen that the cosmetic of the present invention is superior in the effect than Comparative Example 3 containing benzoyl peroxide alone. On the other hand, in the case of containing only indole-3 acetic acid and AHA (Comparative Example 2), it can be seen that the effect is very small compared to the present invention, it is known that the exfoliation function and sterilization function excellent in the cosmetic of the present invention When the salicylic acid is further added in the maximum amount (0.5 weight) that can be added to the cosmetic (Comparative Example 1), although the acne healing effect appears quickly, the overall effect can be seen that the cosmetic of the present invention is better.

<Test Example 2> Skin irritation evaluation

The gels of Examples 1 and Comparative Examples 1 to 3 were buried in the respective intelligence test pin chambers, and then fixed to the inside of the lower abdomen for 48 hours with tapes for 19 people in groups 1 to 4, and then the pin chambers were removed. The result after time passed was determined. The determination was performed based on the following visual judgment criteria, and the stimulus degree was calculated based on Equation 1 below, and the results are shown in Table 7.

<Visual judgment standard>

+ Erythema sign Remarks weight No side effects Positive drug positive Positive positive positive -+-++++++ No erythema Appears slightly reddish than the surroundings Redness more than 1/3 Reddish symptom Reddish blister and browning, accompanied by swelling 01234

<Skin irritation standard>

Stimulus Judgment 0 ~ 0.20.21 ~ 0.50.51 ~ 1.251.26 or more No irritation at all

Blood tester Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Group1 One - - - - 2 - - - +- 3 +- +- - + 4 - - - +- 5 - - - - Group2 One - - - +- 2 - - - +- 3 - - - +- 4 +- - +- + 5 - - - +- Group3 One +- +- - +- 2 - - - - 3 - - - +- 4 - +- - - 5 - - - +- Group 4 2 - - - - 3 - - - - 4 - +- - +- 5 - - - - Stimulus 0.15 0.21 0.05 0.73

From the above Table 7, it can be seen that the cosmetic of the present invention exhibits irritation while the cosmetic containing benzoyl peroxide exhibits no stimulus.

<Test Example 3> Sebum oil amount measurement

The sebum removal efficacy on the gel of Example 1 was measured. In the sebum measurement method, skin fractions were measured by subjects in groups 1 and 2 using Sebummeter SM410 (Courage and Khazaka, Germany). The measurement was performed to measure the extent of light transmission after adsorbing sebum by contacting the surface of the probe with the transparent plastic film and adsorbing sebum. The results are shown in Table 8.

Before cosmetic treatment 4 weeks after cosmetic treatment forehead 볼 (ball) forehead 볼 (ball) Group1 1 (male) 88.65 37.29 84.86 33.86 2 (male) 86.74 35.65 85.04 34.67 3 54.45 16.09 53.07 15.8 4 54.21 17.53 52.75 16.78 5 53.97 15.98 51.98 15.08 Group2 One 54.67 15.78 53.12 14.64 2 55.09 16.09 52.76 15.31 3 57.32 16.13 52.15 15.06 4 54.53 15.58 53.36 14.21 5 53.87 16.32 52.87 15.39

From Table 8, it can be seen that in sebum secretion measurement experiments for population 1 and 2 subjects, sebum is reduced after 4 weeks of cosmetic treatment, such sebum secretion reduction function of pores to reduce sebum causing acne It is by.

As can be seen from the above description, the cosmetic composition of the present invention containing the indole-3 complex has no irritation to the skin, can reduce the secretion of sebum, and can improve the skin keratin caused by acne, Effective for the skin

Claims (1)

Cosmetics for acne skin comprising an indole-3 complex consisting of 0.0001 to 0.01 weight of indole-3 acetic acid, 5.0 to 15.0 weight of carbamide peroxide, and 0.2 to 1.0 weight of α-hydroxy acid, based on the total weight of the composition Composition.