GB581234A - A process for the manufacture of stable surgical dressings containing penicillin - Google Patents

A process for the manufacture of stable surgical dressings containing penicillin

Info

Publication number
GB581234A
GB581234A GB1761844A GB1761844A GB581234A GB 581234 A GB581234 A GB 581234A GB 1761844 A GB1761844 A GB 1761844A GB 1761844 A GB1761844 A GB 1761844A GB 581234 A GB581234 A GB 581234A
Authority
GB
United Kingdom
Prior art keywords
penicillin
solutions
dressings
salts
recoverable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1761844A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALBERT RONALD MOSS
CLAUS WOLFGANG PICARD
SIDNEY CHARLES MITCHELL
Roche Products Ltd
Smith and Nephew Nominee Services Ltd
Original Assignee
ALBERT RONALD MOSS
CLAUS WOLFGANG PICARD
SIDNEY CHARLES MITCHELL
Roche Products Ltd
Herts Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALBERT RONALD MOSS, CLAUS WOLFGANG PICARD, SIDNEY CHARLES MITCHELL, Roche Products Ltd, Herts Pharmaceuticals Ltd filed Critical ALBERT RONALD MOSS
Priority to GB1761844A priority Critical patent/GB581234A/en
Publication of GB581234A publication Critical patent/GB581234A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Artificial Filaments (AREA)

Abstract

For impregnating dressings consisting of absorbent fibrous material there is employed a sterile solution of a salt of penicillin adjusted to a pH value of 5.5-7.5 and preferably 5.5-6.5, which may be prepared from filtered crude penicillin-containing metabolic solutions, or from purified penicillin solutions, or from pure penicillin salts. The penicillin content is recoverable from the impregnated dressings by soaking them in water. Several examples are given, relating to the use of calcium, ammonium, magnesium and a mixture of sodium and potassium salts of penicillin having a bacteriostatic activity ranging between 11 and 900 Oxford units per c.c.ALSO:A dressing consisting of absorbent fibrous material, e.g., cotton gauze, cotton wool, fabrics of glass fibres, nylon, cellulose acetate, spun viscose &c. is impregnated with a sterile solution of a salt of penicillin adjusted to a pH value of 5.5-7.5 and preferably 5.5-6.5, dried to a constant weight and placed in a moisture-proof container. Drying may be effected in a current of air or inert gas such as nitrogen at a temperature not exceeding 120 DEG C., e.g., at 60-85 DEG C. for 5-10 minutes, or by infra-red radiation in a current of air or inert gas, or in vacuo at low temperatures suitably in the presence of a drying agent such as caustic potash or phosphorous pentoxide. The solution employed may be prepared from filtered crude penicillin-containing metabolic solutions, or from purified penicillin solutions, or from pure penicillin salts. The dressings so produced are stable and the penicillin content is recoverable by soaking them in water. Several examples are given, relating to the use of calcium, ammonium, magnesium, and a mixture of sodium and potassium salts of penicillin having a bacteriostatic activity ranging between 11 and 900 Oxford units per c.c.
GB1761844A 1944-09-14 1944-09-14 A process for the manufacture of stable surgical dressings containing penicillin Expired GB581234A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1761844A GB581234A (en) 1944-09-14 1944-09-14 A process for the manufacture of stable surgical dressings containing penicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1761844A GB581234A (en) 1944-09-14 1944-09-14 A process for the manufacture of stable surgical dressings containing penicillin

Publications (1)

Publication Number Publication Date
GB581234A true GB581234A (en) 1946-10-04

Family

ID=10098284

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1761844A Expired GB581234A (en) 1944-09-14 1944-09-14 A process for the manufacture of stable surgical dressings containing penicillin

Country Status (1)

Country Link
GB (1) GB581234A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680701A (en) * 1950-08-24 1954-06-08 Multibiotics Corp Antibiotic-impregnated gauze pads and method of making same
US2804425A (en) * 1952-07-02 1957-08-27 American Cyanamid Co Chlortetracycline gauze and method for production
GB2180152A (en) * 1985-09-11 1987-03-25 Romano Cali Anatomical dressings for cosmetic treatments

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680701A (en) * 1950-08-24 1954-06-08 Multibiotics Corp Antibiotic-impregnated gauze pads and method of making same
US2804425A (en) * 1952-07-02 1957-08-27 American Cyanamid Co Chlortetracycline gauze and method for production
GB2180152A (en) * 1985-09-11 1987-03-25 Romano Cali Anatomical dressings for cosmetic treatments
GB2180152B (en) * 1985-09-11 1989-09-06 Romano Cali Anatomical dressings for cosmetic treatments

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