GB495050A - Process for the production of 2-keto-ª•-gulonic acid - Google Patents
Process for the production of 2-keto-ª•-gulonic acidInfo
- Publication number
- GB495050A GB495050A GB12967/37A GB1296737A GB495050A GB 495050 A GB495050 A GB 495050A GB 12967/37 A GB12967/37 A GB 12967/37A GB 1296737 A GB1296737 A GB 1296737A GB 495050 A GB495050 A GB 495050A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sorbose
- oxygen
- charcoal
- shaken
- platinum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Catalysts (AREA)
Abstract
2-Keto-l-gulonic acid is prepared by the oxidation of l-sorbose in neutral or weakly alkaline solution with oxygen in the presence of a noble metal catalyst. The acid formed is preferably neutralized by the gradual addition of alkaline solutions or buffer mixtures. The reaction mixture may be used directly for the production of ascorbic acid (Vitamin C), or the acid may be isolated thereform by conversion into its methyl ester, diacetone compound or quinine salt. According to the examples, (1) an aqueous solution of sorbose to which secondary sodium phosphate or sodium acetate and platinum-charcoal has been added is shaken up with oxygen and the keto-gulonic acid isolated from the mixture as either the diacetone compound or the quinine salt; (2) an aqueous solution of sorbose is shaken up with oxygen in the presence of platinum-charcoal and the product isolated as before; (3) sorbose is dissolved in water containing a little caustic potash and after addition of platinum-charcoal is shaken up with oxygen, or oxygen is bubbled through, at room temperature; the keto-gulonic acid is separated as its sodium salt or is directly converted into ascorbic acid; (4) an aqueous solution of sorbose to which palladium-charcoal has been added is shaken with oxygen at room temperature and caustic potash is added in portions; the product is isolated or converted as in (3); (5) a solution of sorbose to which a phosphate or borate buffer solution has been added is shaken with oxygen in presence of platinum-charcoal and the product worked up as before; (6) sorbose is dissolved in water with sodium bicarbonate and shaken in the air in presence of platinum-charcoal; sodium keto-gulonate is isolated from the reaction mixture.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE495050X | 1936-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB495050A true GB495050A (en) | 1938-11-07 |
Family
ID=6544827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12967/37A Expired GB495050A (en) | 1936-07-18 | 1937-05-06 | Process for the production of 2-keto-ª•-gulonic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB495050A (en) |
-
1937
- 1937-05-06 GB GB12967/37A patent/GB495050A/en not_active Expired
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