GB565564A - Improvements in or relating to the preparation of 2-keto-l-galactonic acid, its alkali metal salts and methyl ester - Google Patents
Improvements in or relating to the preparation of 2-keto-l-galactonic acid, its alkali metal salts and methyl esterInfo
- Publication number
- GB565564A GB565564A GB14038/42A GB1403842A GB565564A GB 565564 A GB565564 A GB 565564A GB 14038/42 A GB14038/42 A GB 14038/42A GB 1403842 A GB1403842 A GB 1403842A GB 565564 A GB565564 A GB 565564A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- keto
- alkali metal
- galactonate
- vanadium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Alkali metal-l-galactonates are subjected to chlorate oxidation in the presence of a vanadium catalyst in a mildly acid medium, and the resulting alkali metal 2-keto-l-galactonates separated by crystallisation. Crystallised 2-keto-l-galactonic acid may be prepared from the alkali metal salts and may be converted into its methyl ester and brucine salt. The crystallised salts are suitable for the preparation of ascorbic acid. In examples: (1) potassium-l-galactonate is treated in aqueous methanol with potassium chlorate in the presence of vanadium pentoxide and orthophosphoric acid, and the excess vanadium oxide removed by filtration; calcium ferrocyanide is added to remove the vanadium in solution and the phosphate, sulphate and calcium ions removed by adding zirconium sulphate, barium acetate and oxalic acid respectively; after filtering and evaporating, potassium-2-keto-l-galactonate is obtained by crystallisation by adding methyl alcohol; (2) sodium-l-galactonate is similarly oxidised with sodium chlorate, but unreacted l-galactonate is removed from the product by adding calcium acetate. The free acid is liberated from the sodium salt by means of sulphuric acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US565564XA | 1941-12-04 | 1941-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB565564A true GB565564A (en) | 1944-11-16 |
Family
ID=22005182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14038/42A Expired GB565564A (en) | 1941-12-04 | 1942-10-06 | Improvements in or relating to the preparation of 2-keto-l-galactonic acid, its alkali metal salts and methyl ester |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB565564A (en) |
-
1942
- 1942-10-06 GB GB14038/42A patent/GB565564A/en not_active Expired
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