GB460629A - Improvements in local anaesthetics - Google Patents
Improvements in local anaestheticsInfo
- Publication number
- GB460629A GB460629A GB21489/35A GB2148935A GB460629A GB 460629 A GB460629 A GB 460629A GB 21489/35 A GB21489/35 A GB 21489/35A GB 2148935 A GB2148935 A GB 2148935A GB 460629 A GB460629 A GB 460629A
- Authority
- GB
- United Kingdom
- Prior art keywords
- anaesthetic
- benzoic
- solution
- salt
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Anaesthetic solutions are prepared by causing an anaesthetic base which is a benzoic- or paraaminobenzoic ester of an amino alcohol or a para-aminobenzoic ester of a simple alcohol, to react with formic, acetic, salicylic, or benzoic acid; or by double decomposition between the hydrochloride of the anaesthetic and a magnesium, potassium or other salt of one of said acids. In either case the pH of the solution is adjusted to 4 by means of the same acid as is used in making the reaction product. Examples relate to preparations of cocaine and of paraaminobenzoyl-diethylaminoethanol.ALSO:Anaesthetic solutions, which withstand sterilization by heat and are suitable as surface anaesthetics, are prepared by causing an anaesthetic base which is a benzoic- or paraamino-benzoic ester of an amino alcohol or a para-aminobenzoic ester of a simple alcohol, to react with formic, acetic, salicylic or benzoic acid and adjusting the solution to pH4; or by mixing a solution of a salt of the anaesthetic, such as the hydrochloride, with a solution of a salt of one of the said organic acids, preferably a magnesium or potassium salt, and adjusting the pH to 4. Examples relate to preparations of cocaine and para-aminobenzoyl-diethylaminoethanol. The pH of the solutions is adjusted by addition of the same acid as is used in making the reaction product.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US460629XA | 1934-08-03 | 1934-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB460629A true GB460629A (en) | 1937-01-29 |
Family
ID=21941381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB21489/35A Expired GB460629A (en) | 1934-08-03 | 1935-07-29 | Improvements in local anaesthetics |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB460629A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2431553A (en) * | 1945-07-24 | 1947-11-25 | Frederick M Turnbull | Stabilized solutions of local anesthetics |
US5276032A (en) * | 1989-12-28 | 1994-01-04 | King O Newton | Vision aid and anesthetic composition |
-
1935
- 1935-07-29 GB GB21489/35A patent/GB460629A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2431553A (en) * | 1945-07-24 | 1947-11-25 | Frederick M Turnbull | Stabilized solutions of local anesthetics |
US5276032A (en) * | 1989-12-28 | 1994-01-04 | King O Newton | Vision aid and anesthetic composition |
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