GB467080A - Alkaline earth metal double salts of organic acids - Google Patents
Alkaline earth metal double salts of organic acidsInfo
- Publication number
- GB467080A GB467080A GB27427/35A GB2742735A GB467080A GB 467080 A GB467080 A GB 467080A GB 27427/35 A GB27427/35 A GB 27427/35A GB 2742735 A GB2742735 A GB 2742735A GB 467080 A GB467080 A GB 467080A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- benzoic acid
- ester
- benzyl
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 title 1
- 150000001342 alkaline earth metals Chemical class 0.000 title 1
- 150000007524 organic acids Chemical class 0.000 title 1
- 235000005985 organic acids Nutrition 0.000 title 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 10
- 239000005711 Benzoic acid Substances 0.000 abstract 5
- 235000010233 benzoic acid Nutrition 0.000 abstract 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 5
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- -1 ethoxy benzyl Chemical group 0.000 abstract 4
- 229910052749 magnesium Inorganic materials 0.000 abstract 4
- 239000011777 magnesium Substances 0.000 abstract 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 abstract 2
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 239000001384 succinic acid Substances 0.000 abstract 2
- GTOFKXZQQDSVFH-UHFFFAOYSA-N 2-benzylsuccinic acid Chemical compound OC(=O)CC(C(O)=O)CC1=CC=CC=C1 GTOFKXZQQDSVFH-UHFFFAOYSA-N 0.000 abstract 1
- XDZMPRGFOOFSBL-UHFFFAOYSA-N 2-ethoxybenzoic acid Chemical compound CCOC1=CC=CC=C1C(O)=O XDZMPRGFOOFSBL-UHFFFAOYSA-N 0.000 abstract 1
- TVYRJQXMQNZLNO-UHFFFAOYSA-N 3-acetyl-2-hydroxybenzoic acid Chemical compound CC(=O)C1=CC=CC(C(O)=O)=C1O TVYRJQXMQNZLNO-UHFFFAOYSA-N 0.000 abstract 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000001361 adipic acid Substances 0.000 abstract 1
- 235000011037 adipic acid Nutrition 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 235000011116 calcium hydroxide Nutrition 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000006289 hydroxybenzyl group Chemical group 0.000 abstract 1
- 229910052712 strontium Inorganic materials 0.000 abstract 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Medicinal compounds having varied therapeutic qualities are prepared by reacting an oxide of calcium, strontium or magnesium with a mono-ester of a dibasic aliphatic acid and benzoic acid or a nuclear substituted benzoic acid in substantially equimolecular proportions. Thus one mol. of slaked lime may be heated and stirred in aqueous suspension with one mol. of benzoic acid, the temperature lowered to 80 DEG C., and one mol. of the monobenzyl ester of succinic acid added whereupon the double calcium salt of benzoic and monobenzyl succinic acid separates. In other examples o-ethoxy benzoic acid and acetyl o-hydroxy benzoic acid are employed in place of benzoic acid in the above example, but in the latter case the reaction is carried out in anhydrous alcohol to prevent hydrolysis of the acetyl group. Amino groups may also be present, and the radicle of the mono ester of the dibasic acid may be an alkyl, aralkyl, or substituted aralkyl radicle such as hydroxy benzyl, ethoxy benzyl, acetyl hydroxy benzyl, or amino benzyl. Samples have been furnished under Sect. 2 (5) of the magnesium double salt of p-amino-benzoic acid and the mono-anisyl ester of adipic acid, the magnesium double salt of p-hydroxy-benzoic acid and the monoethyl ester of malonic acid, the magnesium double salt of benzoic acid and the monobenzyl ester of succinic acid, and the calcium double salt of p-amino-benzoic acid and the mono-benzyl ester of succinic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US467080XA | 1934-10-11 | 1934-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB467080A true GB467080A (en) | 1937-06-04 |
Family
ID=21944945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27427/35A Expired GB467080A (en) | 1934-10-11 | 1935-10-04 | Alkaline earth metal double salts of organic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB467080A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1201140A1 (en) * | 2000-10-11 | 2002-05-02 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Calcium double salts, their synthesis and use as preservatives |
-
1935
- 1935-10-04 GB GB27427/35A patent/GB467080A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1201140A1 (en) * | 2000-10-11 | 2002-05-02 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Calcium double salts, their synthesis and use as preservatives |
| US6693216B2 (en) | 2000-10-11 | 2004-02-17 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Calcium double salts |
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