GB826360A - Retrocortin esters and their preparation - Google Patents
Retrocortin esters and their preparationInfo
- Publication number
- GB826360A GB826360A GB36491/55A GB3649155A GB826360A GB 826360 A GB826360 A GB 826360A GB 36491/55 A GB36491/55 A GB 36491/55A GB 3649155 A GB3649155 A GB 3649155A GB 826360 A GB826360 A GB 826360A
- Authority
- GB
- United Kingdom
- Prior art keywords
- retrocortin
- pyridine
- anhydride
- hemi
- chloroform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention comprises retrocortin esters of the formula <FORM:0826360/IV (b)/1> (wherein R is a carboxyacyl radical), and alkali and alkaline earth metal salts thereof, together with a process for their preparation by reacting retrocortin with an acylating agent derived from a polybasic carboxylic acid, e.g. an acid anhydride or halogenide in the presence of a tertiary amine and conveniently in an organic solvent, e.g. pyridine, benzene or chloroform and, if desired, treating the resulting ester with an aqueous solution (preferably containing a lower aliphatic alcohol) of a basic alkali or alkaline earth metal compound, e.g. a carbonate, bicarbonate, or hydroxide, to form a salt. Specified polybasic acids are succinic, glutaric, maleic, adipic and phthalic, and the reaction is preferably effected in pyridine, benzene or chloroform as solvent. In examples: (1) retrocortin is stirred at room temperature in pyridine containing succinic anhydride, the mixture added dropwise to excess dilute HC1 when retrocortin 21-hemi-succinate precipitates; subsequent treatment with sodium carbonate in aqueous ethanol gives the corresponding sodium salt (2), as in (1) using maleic anhydride to yield the 21-hemi-maleate, and (3), as in (1) using phthalic anhydride to give the 21-hemiphthalate. Specification 823,940 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US826360XA | 1955-01-14 | 1955-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB826360A true GB826360A (en) | 1960-01-06 |
Family
ID=22172408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36491/55A Expired GB826360A (en) | 1955-01-14 | 1955-12-20 | Retrocortin esters and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB826360A (en) |
-
1955
- 1955-12-20 GB GB36491/55A patent/GB826360A/en not_active Expired
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