GB425406A - Improvements in or relating to the manufacture of medical preparations of bacterial toxins - Google Patents

Improvements in or relating to the manufacture of medical preparations of bacterial toxins

Info

Publication number
GB425406A
GB425406A GB1636133A GB1636133A GB425406A GB 425406 A GB425406 A GB 425406A GB 1636133 A GB1636133 A GB 1636133A GB 1636133 A GB1636133 A GB 1636133A GB 425406 A GB425406 A GB 425406A
Authority
GB
United Kingdom
Prior art keywords
emulsion
oil
bacteria
bacterial toxins
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1636133A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB1636133A priority Critical patent/GB425406A/en
Publication of GB425406A publication Critical patent/GB425406A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria

Abstract

Bacterial toxins for subcutaneous and like injection are incorporated in a fine emulsion of a fatty oil or fat so as to be adsorbed on the dispersed particles of the oil or fat. The toxin may be added to the emulsion or the oil &c., may be emulsified in an aqueous medium containing the toxin. The diameter of the oil particles in the emulsion is preferably about 1/2 m , and should not exceed 1 1/2 m , and the emulsion may be made by means of the apparatus described in Specification 323,534, [Class 81 (i)], operating at a pressure of 3000 to 4000 lbs., per sq. inch. Endotoxins for use in the process may be prepared by a preliminary passage of a suspension of bacteria through the emulsifier so as to disrupt the bacteria and release the toxins; alternatively the bacteria may be disrupted by other mechanical means, or solutions of bacteria prepared according to Specification 425,216 may be used. The emulsion may be one containing from 5 to 30 per cent of olive oil emulsified by means of sodium carbonate and oleic acid or by means of gum acacia; it may be adjusted to pH 7,4 to 8,0, and may be sterilized at 60 DEG C. Phenol may be added to the continuous phase or to the finished emulsion. Specification 417,715 also is referred to.
GB1636133A 1933-06-07 1933-06-07 Improvements in or relating to the manufacture of medical preparations of bacterial toxins Expired GB425406A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1636133A GB425406A (en) 1933-06-07 1933-06-07 Improvements in or relating to the manufacture of medical preparations of bacterial toxins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1636133A GB425406A (en) 1933-06-07 1933-06-07 Improvements in or relating to the manufacture of medical preparations of bacterial toxins

Publications (1)

Publication Number Publication Date
GB425406A true GB425406A (en) 1935-03-07

Family

ID=10075916

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1636133A Expired GB425406A (en) 1933-06-07 1933-06-07 Improvements in or relating to the manufacture of medical preparations of bacterial toxins

Country Status (1)

Country Link
GB (1) GB425406A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083142A (en) * 1958-02-27 1963-03-26 Glaxo Group Ltd Improved swine erysipelas vaccine
EP0129923A1 (en) * 1983-06-06 1985-01-02 Duphar International Research B.V Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained
WO2006079989A2 (en) * 2005-01-28 2006-08-03 North-West University Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083142A (en) * 1958-02-27 1963-03-26 Glaxo Group Ltd Improved swine erysipelas vaccine
EP0129923A1 (en) * 1983-06-06 1985-01-02 Duphar International Research B.V Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained
WO2006079989A2 (en) * 2005-01-28 2006-08-03 North-West University Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
WO2006079989A3 (en) * 2005-01-28 2006-10-12 Univ Northwest Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
US9585955B2 (en) 2005-01-28 2017-03-07 North-West University Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

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