GB2628746A - Terpenophenolic compounds and their use - Google Patents

Terpenophenolic compounds and their use Download PDF

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Publication number
GB2628746A
GB2628746A GB2410277.4A GB202410277A GB2628746A GB 2628746 A GB2628746 A GB 2628746A GB 202410277 A GB202410277 A GB 202410277A GB 2628746 A GB2628746 A GB 2628746A
Authority
GB
United Kingdom
Prior art keywords
cbd
pet
compound
trans
prop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB2410277.4A
Other languages
English (en)
Other versions
GB202410277D0 (en
Inventor
George Stott Colin
R Heap Charles
Gurusankar Ramamoorthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phytotherapeutix Ltd
Original Assignee
Phytotherapeutix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytotherapeutix Ltd filed Critical Phytotherapeutix Ltd
Priority to GB2410277.4A priority Critical patent/GB2628746A/en
Publication of GB202410277D0 publication Critical patent/GB202410277D0/en
Publication of GB2628746A publication Critical patent/GB2628746A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2410277.4A 2020-03-31 2021-03-31 Terpenophenolic compounds and their use Withdrawn GB2628746A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2410277.4A GB2628746A (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003270P 2020-03-31 2020-03-31
GB2410277.4A GB2628746A (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use
GB2215746.5A GB2609814B (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use

Publications (2)

Publication Number Publication Date
GB202410277D0 GB202410277D0 (en) 2024-08-28
GB2628746A true GB2628746A (en) 2024-10-02

Family

ID=75426633

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2410277.4A Withdrawn GB2628746A (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use
GB2104690.9A Withdrawn GB2595355A (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use
GB2215746.5A Active GB2609814B (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB2104690.9A Withdrawn GB2595355A (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use
GB2215746.5A Active GB2609814B (en) 2020-03-31 2021-03-31 Terpenophenolic compounds and their use

Country Status (11)

Country Link
US (2) US12552733B2 (enExample)
EP (1) EP4126800A1 (enExample)
JP (1) JP7714571B2 (enExample)
KR (1) KR20230121960A (enExample)
CN (1) CN116194431B (enExample)
AU (1) AU2021248627A1 (enExample)
BR (1) BR112022019616A2 (enExample)
GB (3) GB2628746A (enExample)
IL (1) IL296861A (enExample)
MX (1) MX2022011832A (enExample)
WO (1) WO2021198692A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3959193A4 (en) * 2019-05-23 2022-07-13 Kare Chemical Technologies Inc. Catalytic cannabinoid processes and precursors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012201041A1 (en) * 2005-09-29 2012-03-15 Albany Molecular Research, Inc. Process for production of delta-9-tetrahydrocannabinol
WO2019049806A1 (en) * 2017-09-06 2019-03-14 Sumitomo Wiring Systems, Ltd. SHIELD CONNECTOR AND ITS ASSEMBLY METHOD
EP3319952B1 (en) * 2015-07-10 2020-02-05 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136839A (en) * 2000-06-16 2006-12-10 Yissum Res Dev Co Pharmaceutical compositions comprising cannabidiol derivatives, and processes for the preparation of same
EP2578561A1 (en) 2005-09-29 2013-04-10 Albany Molecular Research, Inc. Processes for the production of cannabidiol derivatives and intermediates thereof
DK2176208T3 (en) * 2007-07-30 2015-04-27 Zynerba Pharmaceuticals Inc Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof
DE102009019322A1 (de) 2009-04-30 2010-11-11 The Health Concept Gmbh Verfahren zur Herstellung von Synthetischen Cannabinoiden
TWI583374B (zh) * 2010-03-30 2017-05-21 Ｇｗ伐瑪有限公司 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途
WO2014177593A1 (en) 2013-04-29 2014-11-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Amorfrutin analogs as ppargamma-modulators
US9526706B1 (en) 2015-06-16 2016-12-27 Hong Kong Baptist University Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury
US9738581B2 (en) * 2015-06-16 2017-08-22 Hong Kong Baptist University Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions
CN109311838A (zh) 2016-04-15 2019-02-05 蒂温诺特技术有限公司 大麻素前药的生物合成
US20170362195A1 (en) 2016-06-16 2017-12-21 Full Spectrum Laboratories Ltd Methods for the manufacture of cannabinoid prodrugs, pharmaceutical formulations and their use
US10640482B2 (en) 2017-07-21 2020-05-05 University Of South Florida Synthesis of cannabinoids
CN111372907A (zh) 2017-09-01 2020-07-03 普优峰全球股份有限公司 合成大麻二酚组合物和用于制备其的方法
EP3840854A4 (en) * 2018-08-20 2022-06-29 Bessor Pharma, LLC Novel cannabinoids and cannabinoid acids and their derivatives
EP3959193A4 (en) * 2019-05-23 2022-07-13 Kare Chemical Technologies Inc. Catalytic cannabinoid processes and precursors
CA3150642A1 (en) * 2019-09-09 2021-03-18 Kamaluddin Abdur-Rashid CANNABINOID DERIVATIVES, PRECURSORS AND USES
CA3150646A1 (en) * 2019-09-10 2021-03-18 Kamaluddin Abdur-Rashid CANNABINOID DERIVATIVES AND PRECURSORS, AND ASYMMETRICAL SYNTHESIS THEREOF

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012201041A1 (en) * 2005-09-29 2012-03-15 Albany Molecular Research, Inc. Process for production of delta-9-tetrahydrocannabinol
EP3319952B1 (en) * 2015-07-10 2020-02-05 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
WO2019049806A1 (en) * 2017-09-06 2019-03-14 Sumitomo Wiring Systems, Ltd. SHIELD CONNECTOR AND ITS ASSEMBLY METHOD

Also Published As

Publication number Publication date
GB2609814A (en) 2023-02-15
MX2022011832A (es) 2023-03-03
GB2595355A (en) 2021-11-24
WO2021198692A1 (en) 2021-10-07
CN116194431B (zh) 2026-01-02
CA3177186A1 (en) 2021-10-07
IL296861A (en) 2022-11-01
CN116194431A (zh) 2023-05-30
AU2021248627A1 (en) 2022-12-01
EP4126800A1 (en) 2023-02-08
US20230227390A1 (en) 2023-07-20
US20230225985A1 (en) 2023-07-20
GB202410277D0 (en) 2024-08-28
JP7714571B2 (ja) 2025-07-29
US12552733B2 (en) 2026-02-17
GB2609814B (en) 2024-08-28
GB202104690D0 (en) 2021-05-12
JP2023520794A (ja) 2023-05-19
GB202215746D0 (en) 2022-12-07
BR112022019616A2 (pt) 2022-12-06
KR20230121960A (ko) 2023-08-22

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)