CN116194431B - 萜酚化合物及其用途 - Google Patents
萜酚化合物及其用途Info
- Publication number
- CN116194431B CN116194431B CN202180038597.7A CN202180038597A CN116194431B CN 116194431 B CN116194431 B CN 116194431B CN 202180038597 A CN202180038597 A CN 202180038597A CN 116194431 B CN116194431 B CN 116194431B
- Authority
- CN
- China
- Prior art keywords
- cbd
- pet
- compound
- biphenyl
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003270P | 2020-03-31 | 2020-03-31 | |
| US63/003,270 | 2020-03-31 | ||
| PCT/GB2021/050812 WO2021198692A1 (en) | 2020-03-31 | 2021-03-31 | Terpenophenolic compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116194431A CN116194431A (zh) | 2023-05-30 |
| CN116194431B true CN116194431B (zh) | 2026-01-02 |
Family
ID=75426633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180038597.7A Active CN116194431B (zh) | 2020-03-31 | 2021-03-31 | 萜酚化合物及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12552733B2 (enExample) |
| EP (1) | EP4126800A1 (enExample) |
| JP (1) | JP7714571B2 (enExample) |
| KR (1) | KR20230121960A (enExample) |
| CN (1) | CN116194431B (enExample) |
| AU (1) | AU2021248627A1 (enExample) |
| BR (1) | BR112022019616A2 (enExample) |
| GB (3) | GB2628746A (enExample) |
| IL (1) | IL296861A (enExample) |
| MX (1) | MX2022011832A (enExample) |
| WO (1) | WO2021198692A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3959193A4 (en) * | 2019-05-23 | 2022-07-13 | Kare Chemical Technologies Inc. | Catalytic cannabinoid processes and precursors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046806A1 (en) * | 2017-09-01 | 2019-03-07 | Botaniteck Llc | SYNTHETIC CANNABIDIOL COMPOSITIONS AND METHODS OF MAKING THE SAME |
| CN109939091A (zh) * | 2015-06-16 | 2019-06-28 | 香港浸会大学 | 化合物在制备用于治疗结肠直肠癌的药物中的用途 |
| WO2020041326A1 (en) * | 2018-08-20 | 2020-02-27 | Berkowitz Barry A | Applications of known and novel cannabinoids |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136839A (en) * | 2000-06-16 | 2006-12-10 | Yissum Res Dev Co | Pharmaceutical compositions comprising cannabidiol derivatives, and processes for the preparation of same |
| EP2578561A1 (en) | 2005-09-29 | 2013-04-10 | Albany Molecular Research, Inc. | Processes for the production of cannabidiol derivatives and intermediates thereof |
| AU2012201041B2 (en) * | 2005-09-29 | 2012-12-06 | Albany Molecular Research, Inc. | Process for production of delta-9-tetrahydrocannabinol |
| DK2176208T3 (en) * | 2007-07-30 | 2015-04-27 | Zynerba Pharmaceuticals Inc | Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof |
| DE102009019322A1 (de) | 2009-04-30 | 2010-11-11 | The Health Concept Gmbh | Verfahren zur Herstellung von Synthetischen Cannabinoiden |
| TWI583374B (zh) * | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| WO2014177593A1 (en) | 2013-04-29 | 2014-11-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Amorfrutin analogs as ppargamma-modulators |
| US9526706B1 (en) | 2015-06-16 | 2016-12-27 | Hong Kong Baptist University | Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury |
| US20170008869A1 (en) * | 2015-07-10 | 2017-01-12 | Noramco, Inc. | Process for the production of cannabidiol and delta-9-tetrahydrocannabinol |
| CN109311838A (zh) | 2016-04-15 | 2019-02-05 | 蒂温诺特技术有限公司 | 大麻素前药的生物合成 |
| US20170362195A1 (en) | 2016-06-16 | 2017-12-21 | Full Spectrum Laboratories Ltd | Methods for the manufacture of cannabinoid prodrugs, pharmaceutical formulations and their use |
| US10640482B2 (en) | 2017-07-21 | 2020-05-05 | University Of South Florida | Synthesis of cannabinoids |
| DE102017008367B4 (de) * | 2017-09-06 | 2019-06-13 | Sumitomo Wiring Systems, Ltd. | Abschirmverbinder und Verfahren zum Zusammenbauen desselben |
| EP3959193A4 (en) * | 2019-05-23 | 2022-07-13 | Kare Chemical Technologies Inc. | Catalytic cannabinoid processes and precursors |
| CA3150642A1 (en) * | 2019-09-09 | 2021-03-18 | Kamaluddin Abdur-Rashid | CANNABINOID DERIVATIVES, PRECURSORS AND USES |
| CA3150646A1 (en) * | 2019-09-10 | 2021-03-18 | Kamaluddin Abdur-Rashid | CANNABINOID DERIVATIVES AND PRECURSORS, AND ASYMMETRICAL SYNTHESIS THEREOF |
-
2021
- 2021-03-31 CN CN202180038597.7A patent/CN116194431B/zh active Active
- 2021-03-31 GB GB2410277.4A patent/GB2628746A/en not_active Withdrawn
- 2021-03-31 MX MX2022011832A patent/MX2022011832A/es unknown
- 2021-03-31 JP JP2022560311A patent/JP7714571B2/ja active Active
- 2021-03-31 GB GB2104690.9A patent/GB2595355A/en not_active Withdrawn
- 2021-03-31 EP EP21717177.6A patent/EP4126800A1/en active Pending
- 2021-03-31 KR KR1020227037909A patent/KR20230121960A/ko active Pending
- 2021-03-31 WO PCT/GB2021/050812 patent/WO2021198692A1/en not_active Ceased
- 2021-03-31 BR BR112022019616A patent/BR112022019616A2/pt unknown
- 2021-03-31 AU AU2021248627A patent/AU2021248627A1/en active Pending
- 2021-03-31 GB GB2215746.5A patent/GB2609814B/en active Active
- 2021-03-31 US US17/916,494 patent/US12552733B2/en active Active
- 2021-03-31 IL IL296861A patent/IL296861A/en unknown
-
2022
- 2022-09-30 US US17/958,083 patent/US20230225985A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109939091A (zh) * | 2015-06-16 | 2019-06-28 | 香港浸会大学 | 化合物在制备用于治疗结肠直肠癌的药物中的用途 |
| WO2019046806A1 (en) * | 2017-09-01 | 2019-03-07 | Botaniteck Llc | SYNTHETIC CANNABIDIOL COMPOSITIONS AND METHODS OF MAKING THE SAME |
| WO2020041326A1 (en) * | 2018-08-20 | 2020-02-27 | Berkowitz Barry A | Applications of known and novel cannabinoids |
Non-Patent Citations (2)
| Title |
|---|
| Leslie W. Crombie等.Synthesis of bibenzyl cannabinoids hybrids of two biogenetic series found in Cannabis sativa.J. CHEM. SOC. PERKIN TRANS. I.1988,(第5期),第1265、1269页. * |
| Synthesis of bibenzyl cannabinoids hybrids of two biogenetic series found in Cannabis sativa;Leslie W. Crombie等;J. CHEM. SOC. PERKIN TRANS. I;19880101(第5期);第1265、1269页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2609814A (en) | 2023-02-15 |
| MX2022011832A (es) | 2023-03-03 |
| GB2595355A (en) | 2021-11-24 |
| WO2021198692A1 (en) | 2021-10-07 |
| CA3177186A1 (en) | 2021-10-07 |
| IL296861A (en) | 2022-11-01 |
| CN116194431A (zh) | 2023-05-30 |
| AU2021248627A1 (en) | 2022-12-01 |
| EP4126800A1 (en) | 2023-02-08 |
| US20230227390A1 (en) | 2023-07-20 |
| US20230225985A1 (en) | 2023-07-20 |
| GB202410277D0 (en) | 2024-08-28 |
| JP7714571B2 (ja) | 2025-07-29 |
| US12552733B2 (en) | 2026-02-17 |
| GB2628746A (en) | 2024-10-02 |
| GB2609814B (en) | 2024-08-28 |
| GB202104690D0 (en) | 2021-05-12 |
| JP2023520794A (ja) | 2023-05-19 |
| GB202215746D0 (en) | 2022-12-07 |
| BR112022019616A2 (pt) | 2022-12-06 |
| KR20230121960A (ko) | 2023-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |