GB2485169A - (R)-flurbiprofen for use in the treatment of multiple sclerosis - Google Patents

(R)-flurbiprofen for use in the treatment of multiple sclerosis Download PDF

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Publication number
GB2485169A
GB2485169A GB1018519.7A GB201018519A GB2485169A GB 2485169 A GB2485169 A GB 2485169A GB 201018519 A GB201018519 A GB 201018519A GB 2485169 A GB2485169 A GB 2485169A
Authority
GB
United Kingdom
Prior art keywords
flurbiprofen
treatment
multiple sclerosis
present
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1018519.7A
Other languages
English (en)
Other versions
GB201018519D0 (en
Inventor
Irmgard Tegeder
Gerd Geisslinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goethe Universitaet Frankfurt am Main
Original Assignee
Goethe Universitaet Frankfurt am Main
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goethe Universitaet Frankfurt am Main filed Critical Goethe Universitaet Frankfurt am Main
Priority to GB1018519.7A priority Critical patent/GB2485169A/en
Publication of GB201018519D0 publication Critical patent/GB201018519D0/en
Priority to RU2013125470/15A priority patent/RU2595861C2/ru
Priority to CN2011800529378A priority patent/CN103209692A/zh
Priority to CA2816911A priority patent/CA2816911C/en
Priority to KR1020137010891A priority patent/KR101877587B1/ko
Priority to JP2013537131A priority patent/JP5903438B2/ja
Priority to BR112013010883A priority patent/BR112013010883A2/pt
Priority to EP11784967.9A priority patent/EP2635271A1/en
Priority to US13/881,088 priority patent/US20130309199A1/en
Priority to PCT/EP2011/069319 priority patent/WO2012059541A1/en
Publication of GB2485169A publication Critical patent/GB2485169A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
GB1018519.7A 2010-11-03 2010-11-03 (R)-flurbiprofen for use in the treatment of multiple sclerosis Withdrawn GB2485169A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB1018519.7A GB2485169A (en) 2010-11-03 2010-11-03 (R)-flurbiprofen for use in the treatment of multiple sclerosis
PCT/EP2011/069319 WO2012059541A1 (en) 2010-11-03 2011-11-03 Novel treatment of multiple sclerosis (ms)
KR1020137010891A KR101877587B1 (ko) 2010-11-03 2011-11-03 다발성 경화증(ms)의 새로운 치료
CN2011800529378A CN103209692A (zh) 2010-11-03 2011-11-03 多发性硬化(ms)的新疗法
CA2816911A CA2816911C (en) 2010-11-03 2011-11-03 Novel treatment of multiple sclerosis (ms)
RU2013125470/15A RU2595861C2 (ru) 2010-11-03 2011-11-03 Новое лечение рассеянного склероза ( рс )
JP2013537131A JP5903438B2 (ja) 2010-11-03 2011-11-03 多発性硬化症（ｍｓ）の新規の治療
BR112013010883A BR112013010883A2 (pt) 2010-11-03 2011-11-03 tratamento de esclerose múltipla (ms)
EP11784967.9A EP2635271A1 (en) 2010-11-03 2011-11-03 Novel treatment of multiple sclerosis (ms)
US13/881,088 US20130309199A1 (en) 2010-11-03 2011-11-03 Novel Treatment of Multiple Sclerosis (MS)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1018519.7A GB2485169A (en) 2010-11-03 2010-11-03 (R)-flurbiprofen for use in the treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
GB201018519D0 GB201018519D0 (en) 2010-12-15
GB2485169A true GB2485169A (en) 2012-05-09

Family

ID=43401688

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1018519.7A Withdrawn GB2485169A (en) 2010-11-03 2010-11-03 (R)-flurbiprofen for use in the treatment of multiple sclerosis

Country Status (10)

Country Link
US (1) US20130309199A1 (enrdf_load_stackoverflow)
EP (1) EP2635271A1 (enrdf_load_stackoverflow)
JP (1) JP5903438B2 (enrdf_load_stackoverflow)
KR (1) KR101877587B1 (enrdf_load_stackoverflow)
CN (1) CN103209692A (enrdf_load_stackoverflow)
BR (1) BR112013010883A2 (enrdf_load_stackoverflow)
CA (1) CA2816911C (enrdf_load_stackoverflow)
GB (1) GB2485169A (enrdf_load_stackoverflow)
RU (1) RU2595861C2 (enrdf_load_stackoverflow)
WO (1) WO2012059541A1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA035792B1 (ru) * 2018-06-21 2020-08-11 Государственное Научное Учреждение "Институт Биоорганической Химии Национальной Академии Наук Беларуси" Лекарственное средство пролонгированного действия для лечения рассеянного склероза (варианты)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017080989A1 (en) 2015-11-09 2017-05-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (r)-fluriprofen for the prevention and/or treatment of diabetes
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
IL301455B2 (en) 2016-08-31 2024-04-01 Mapi Pharma Ltd Depot systems comprising glatiramer acetate
EP3600553A4 (en) 2017-03-26 2020-09-02 Mapi Pharma Ltd. GLATIRAMER DEPOSIT SYSTEMS FOR TREATMENT OF PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS
EP3709986B1 (en) 2017-11-14 2023-11-01 Merck Sharp & Dohme LLC Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
CA3082108A1 (en) 2017-11-14 2019-05-23 Merck Sharp & Dohme Corp. Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
WO2022089598A1 (zh) * 2020-10-30 2022-05-05 杭州拉林智能科技有限公司 黄酮苷-有机胺类神经激动剂复盐化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
WO2008036733A2 (en) * 2006-09-19 2008-03-27 Myriad Genetics, Inc. Methods for treatment of vesicle transport disorders
US20090162421A1 (en) * 2007-12-21 2009-06-25 Paz Arzneimittel-Entwicklungsgesellschaft Mbh Drugs as well as their production and use in the treatment of pain-associated neuropathies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907895A1 (de) * 1999-02-24 2000-11-16 Paz Arzneimittelentwicklung Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen bei Mensch und Tier, welche durch die Hemmung der Aktivierung von NF-kB therapeutisch beeinflußt werden können
US7332516B2 (en) * 2003-01-14 2008-02-19 Merck + Co., Inc. Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
ATE526015T1 (de) * 2007-12-21 2011-10-15 Horizon Pharma Ag Arzneimittel sowie deren herstellung und verwendung bei der behandlung von schmerzhaften neuropathien
CN102844290B (zh) * 2010-04-21 2015-06-17 奇斯药制品公司 用于治疗转甲状腺素蛋白淀粉样变性的1-(2-氟联苯-4-基)-烷基羧酸衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008036733A2 (en) * 2006-09-19 2008-03-27 Myriad Genetics, Inc. Methods for treatment of vesicle transport disorders
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
US20090162421A1 (en) * 2007-12-21 2009-06-25 Paz Arzneimittel-Entwicklungsgesellschaft Mbh Drugs as well as their production and use in the treatment of pain-associated neuropathies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA035792B1 (ru) * 2018-06-21 2020-08-11 Государственное Научное Учреждение "Институт Биоорганической Химии Национальной Академии Наук Беларуси" Лекарственное средство пролонгированного действия для лечения рассеянного склероза (варианты)

Also Published As

Publication number Publication date
WO2012059541A1 (en) 2012-05-10
RU2013125470A (ru) 2014-12-10
JP2014505015A (ja) 2014-02-27
KR20140017494A (ko) 2014-02-11
BR112013010883A2 (pt) 2016-09-13
KR101877587B1 (ko) 2018-07-11
JP5903438B2 (ja) 2016-04-13
CA2816911A1 (en) 2012-05-10
EP2635271A1 (en) 2013-09-11
GB201018519D0 (en) 2010-12-15
US20130309199A1 (en) 2013-11-21
CN103209692A (zh) 2013-07-17
RU2595861C2 (ru) 2016-08-27
CA2816911C (en) 2018-09-25

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