GB2393733B - Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease - Google Patents
Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's diseaseInfo
- Publication number
- GB2393733B GB2393733B GB0400167A GB0400167A GB2393733B GB 2393733 B GB2393733 B GB 2393733B GB 0400167 A GB0400167 A GB 0400167A GB 0400167 A GB0400167 A GB 0400167A GB 2393733 B GB2393733 B GB 2393733B
- Authority
- GB
- United Kingdom
- Prior art keywords
- proliferation
- disease
- precursor cells
- dopaminergic neurons
- treating parkinson
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000018737 Parkinson disease Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000005064 dopaminergic neuron Anatomy 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/888,309 US20020019046A1 (en) | 2000-01-11 | 2001-06-21 | Direct differentiation of human pluripotent stem cells and characterization of differentiated cells |
| US10/157,288 US7250294B2 (en) | 2000-05-17 | 2002-05-28 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| PCT/US2002/019477 WO2003000868A1 (en) | 2001-06-21 | 2002-06-20 | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0400167D0 GB0400167D0 (en) | 2004-02-11 |
| GB2393733A GB2393733A (en) | 2004-04-07 |
| GB2393733B true GB2393733B (en) | 2005-09-14 |
Family
ID=54328829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0400167A Expired - Fee Related GB2393733B (en) | 2001-06-21 | 2002-06-20 | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7250294B2 (https=) |
| EP (1) | EP1404812B1 (https=) |
| JP (4) | JP4526265B2 (https=) |
| KR (2) | KR20090104923A (https=) |
| CN (1) | CN100384986C (https=) |
| AU (1) | AU2002322270B2 (https=) |
| CA (1) | CA2451486C (https=) |
| GB (1) | GB2393733B (https=) |
| IL (2) | IL159324A0 (https=) |
| WO (1) | WO2003000868A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018010B2 (en) | 2009-11-12 | 2015-04-28 | Technion Research & Development Foundation Limited | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US9040297B2 (en) | 2006-08-02 | 2015-05-26 | Technion Research & Development Foundation Limited | Methods of expanding embryonic stem cells in a suspension culture |
| US9404079B2 (en) | 2005-08-29 | 2016-08-02 | Technion Research & Development Foundation Limited | Media for culturing stem cells |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518606D0 (en) | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US20050042749A1 (en) * | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| JP5943533B2 (ja) * | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| WO2003104444A1 (en) * | 2002-06-05 | 2003-12-18 | Es Cell International Pte Ltd | Generation of neural stem cells from undifferentiated human embryonic stem cells |
| US20050101014A1 (en) | 2002-07-11 | 2005-05-12 | Keirstead Hans S. | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US20040224302A1 (en) * | 2002-07-16 | 2004-11-11 | Thomas Jessel | Systems and methods for screening for modulators of neural differentiation |
| US7632679B2 (en) * | 2002-07-16 | 2009-12-15 | The Trustees Of Columbia University In The City Of New York | Systems and methods for screening for modulators of neural differentiation |
| US8293488B2 (en) * | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
| ES2705683T3 (es) | 2002-12-16 | 2019-03-26 | Technion Res & Dev Foundation | Medio de cultivo de células madre pluripotentes |
| WO2004081172A2 (en) * | 2003-03-12 | 2004-09-23 | Reliance Life Sciences Pvt. Ltd. | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
| ZA200401646B (en) * | 2003-03-12 | 2004-06-07 | Reliance Life Sciences Pvt Ltd | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells. |
| US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
| US7820439B2 (en) * | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
| US20050153446A1 (en) * | 2003-11-07 | 2005-07-14 | Steindler Dennis A. | Culturing and differentiating neural precursor cells |
| JP4481706B2 (ja) * | 2004-03-31 | 2010-06-16 | 独立行政法人科学技術振興機構 | 脳梗塞疾患モデルマウス |
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| US20030103949A1 (en) | 2003-06-05 |
| KR20090104923A (ko) | 2009-10-06 |
| US7250294B2 (en) | 2007-07-31 |
| CN1630713A (zh) | 2005-06-22 |
| JP4526265B2 (ja) | 2010-08-18 |
| EP1404812A4 (en) | 2005-01-19 |
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