GB2357488A - Capsules by injection moulding - Google Patents
Capsules by injection moulding Download PDFInfo
- Publication number
- GB2357488A GB2357488A GB9927144A GB9927144A GB2357488A GB 2357488 A GB2357488 A GB 2357488A GB 9927144 A GB9927144 A GB 9927144A GB 9927144 A GB9927144 A GB 9927144A GB 2357488 A GB2357488 A GB 2357488A
- Authority
- GB
- United Kingdom
- Prior art keywords
- capsule
- injection
- cap
- capsules
- moulded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 219
- 238000001746 injection moulding Methods 0.000 title abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 38
- 239000007787 solid Substances 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 24
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 24
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 23
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims abstract description 23
- 238000004090 dissolution Methods 0.000 claims abstract description 10
- 230000003068 static effect Effects 0.000 claims abstract description 8
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 5
- 238000012384 transportation and delivery Methods 0.000 claims description 21
- 229920000642 polymer Polymers 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 15
- 238000000465 moulding Methods 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 3
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- -1 alkali metal salt Chemical class 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 229930016911 cinnamic acid Natural products 0.000 claims description 3
- 235000013985 cinnamic acid Nutrition 0.000 claims description 3
- 238000013461 design Methods 0.000 claims description 3
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 9
- 239000012815 thermoplastic material Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 28
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- 229920000159 gelatin Polymers 0.000 description 27
- 235000019322 gelatine Nutrition 0.000 description 27
- 229940079593 drug Drugs 0.000 description 26
- 238000003466 welding Methods 0.000 description 21
- 210000002784 stomach Anatomy 0.000 description 20
- 239000004615 ingredient Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000011324 bead Substances 0.000 description 10
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- 238000009472 formulation Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000008187 granular material Substances 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- 238000013270 controlled release Methods 0.000 description 4
- 238000007598 dipping method Methods 0.000 description 4
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- 239000011257 shell material Substances 0.000 description 4
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- 238000005304 joining Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
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- 235000012054 meals Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
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- 210000003462 vein Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000008119 colloidal silica Substances 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 238000003618 dip coating Methods 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 238000010579 first pass effect Methods 0.000 description 2
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- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 238000000275 quality assurance Methods 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 241000272168 Laridae Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 240000000037 Prosopis spicigera Species 0.000 description 1
- 235000006629 Prosopis spicigera Nutrition 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229910001508 alkali metal halide Inorganic materials 0.000 description 1
- 150000008045 alkali metal halides Chemical class 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
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- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000005323 carbonate salts Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
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- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
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- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
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- YZMHQCWXYHARLS-UHFFFAOYSA-N naphthalene-1,2-disulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(S(=O)(=O)O)=CC=C21 YZMHQCWXYHARLS-UHFFFAOYSA-N 0.000 description 1
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- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
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- 239000010695 polyglycol Substances 0.000 description 1
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- 235000012239 silicon dioxide Nutrition 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
- C11D17/041—Compositions releasably affixed on a substrate or incorporated into a dispensing means
- C11D17/042—Water soluble or water disintegrable containers or substrates containing cleaning compositions or additives for cleaning compositions
- C11D17/043—Liquid or thixotropic (gel) compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
- B65D1/22—Boxes or like containers with side walls of substantial depth for enclosing contents
- B65D1/24—Boxes or like containers with side walls of substantial depth for enclosing contents with moulded compartments or partitions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
- B65D1/22—Boxes or like containers with side walls of substantial depth for enclosing contents
- B65D1/26—Thin-walled containers, e.g. formed by deep-drawing operations
- B65D1/30—Groups of containers joined together end-to-end or side-by-side
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3283—Cylindrical or polygonal containers, e.g. bottles, with two or more substantially axially offset, side-by-side compartments for simultaneous dispensing
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
- C11D17/041—Compositions releasably affixed on a substrate or incorporated into a dispensing means
- C11D17/042—Water soluble or water disintegrable containers or substrates containing cleaning compositions or additives for cleaning compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/40—Specific cleaning or washing processes
- C11D2111/46—Specific cleaning or washing processes applying energy, e.g. irradiation
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Wrappers (AREA)
- Packages (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (42)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9927144A GB2357488A (en) | 1999-11-17 | 1999-11-17 | Capsules by injection moulding |
GB0003304A GB2356842A (en) | 1999-11-17 | 2000-02-15 | Injection-moulded capsules |
DE2000222487 DE20022487U1 (de) | 1999-11-17 | 2000-11-17 | Wasserlöslicher Spritzgussbehälter |
ES00978985T ES2222253T3 (es) | 1999-11-17 | 2000-11-17 | Recipientes solubles en agua moldeados por inyeccion. |
ARP000106108 AR029772A1 (es) | 1999-11-17 | 2000-11-17 | Un contenedor rigido, soluble en agua, moldeado por inyeccion hecho de un poli(alcohol vinilico) y/o eter de celulosa; una capsula de lavado; una disposicion de capsulas de lavado; un metodo para fabricar dicha disposicion; un contenedor tipo capsula y un metodo de lavado de vajilla |
GB0028085A GB2358382B (en) | 1999-11-17 | 2000-11-17 | Rigid water-soluble containers |
DE2000613165 DE60013165T2 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher behälter |
GB0203219A GB2370553A (en) | 1999-11-17 | 2000-11-17 | Rigid water-soluble container |
DE20023801U DE20023801U1 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher Behälter |
AT00978985T ATE273868T1 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher behälter |
DE20023802U DE20023802U1 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher Behälter |
CA 2391613 CA2391613C (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
DE2000633864 DE60033864T2 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher Behälter |
GB0130504A GB2370552B (en) | 1999-11-17 | 2000-11-17 | Rigid water soluble containers |
EP20040002534 EP1457431A3 (en) | 1999-11-17 | 2000-11-17 | Injection moulded water-soluble container |
BR0015617A BR0015617A (pt) | 1999-11-17 | 2000-11-17 | Recipiente solúvel em água moldado por injeção |
AU16470/01A AU780424B2 (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
PCT/GB2000/004376 WO2001036290A1 (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
AT04000430T ATE356045T1 (de) | 1999-11-17 | 2000-11-17 | Spritzgegossener wasserlöslicher behälter |
JP2001538251A JP2004500285A (ja) | 1999-11-17 | 2000-11-17 | 射出成型された水溶性容器 |
PL358943A PL197867B1 (pl) | 1999-11-17 | 2000-11-17 | Formowany wtryskowo, rozpuszczalny w wodzie pojemnik |
PL355840A PL197779B1 (pl) | 1999-11-17 | 2000-11-17 | Sztywny, rozpuszczalny w wodzie pojemnik, kapsułka zawierająca samonośny zbiornik oraz zamknięcie, matryca kapsułek piorących, sposób wytwarzania matrycy kapsułek piorących, formowany wtryskowo pojemnik kapsułkowy oraz sposób prania artykułów z wykorzystaniem pojemnika lub kapsułki piorącej |
EP20040000430 EP1447343B1 (en) | 1999-11-17 | 2000-11-17 | Injection moulded water-soluble container |
CNB008170398A CN1206137C (zh) | 1999-11-17 | 2000-11-17 | 注模形成的水溶性容器 |
GB0203220A GB2370554B (en) | 1999-11-17 | 2000-11-17 | Rigid water-soluble containers |
EP05027149.3A EP1647494A3 (en) | 1999-11-17 | 2000-11-17 | Injection moulded water-soluble container |
EP20100183720 EP2266889A3 (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
ES04000430T ES2279233T3 (es) | 1999-11-17 | 2000-11-17 | Recipiente soluble en agua moldeado por inyeccion. |
MXPA02004981A MXPA02004981A (es) | 1999-11-17 | 2000-11-17 | Capsula soluble en agua moldeada por inyeccion. |
EP20000978985 EP1232100B1 (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
CA002414395A CA2414395A1 (en) | 1999-11-17 | 2000-11-17 | Injection-moulded water-soluble container |
CNB021468257A CN1210190C (zh) | 1999-11-17 | 2000-11-17 | 注模形成的水溶性容器 |
GB0222116A GB2376676B (en) | 1999-11-17 | 2000-11-17 | Rigid water-soluble containers |
US10/150,216 US20030108705A1 (en) | 1999-11-17 | 2002-05-17 | Injection-molded water soluble container |
ZA200204662A ZA200204662B (en) | 1999-11-17 | 2002-06-11 | Injection-moulded water-soluble container. |
JP2002303774A JP4989835B2 (ja) | 1999-11-17 | 2002-10-18 | 射出成型された水溶性容器 |
US10/748,073 US20040151855A1 (en) | 1999-11-17 | 2003-12-30 | Injection-molded water soluble container |
US11/844,493 US20080073239A1 (en) | 1999-11-17 | 2007-08-24 | Injection-Molded Water Soluble Container |
US12/171,043 US20090008820A1 (en) | 1999-11-17 | 2008-07-10 | Injection Molded Water-Soluble Container |
US12/171,057 US20080296196A1 (en) | 1999-11-17 | 2008-07-10 | Injection Molded Water-Soluble Container |
US12/508,344 US20100021534A1 (en) | 1999-11-17 | 2009-07-23 | Injection-molded water soluble container |
US13/114,597 US20110250241A1 (en) | 1999-11-17 | 2011-05-24 | Injection-moulded water-soluble container |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9927144A GB2357488A (en) | 1999-11-17 | 1999-11-17 | Capsules by injection moulding |
Publications (2)
Publication Number | Publication Date |
---|---|
GB9927144D0 GB9927144D0 (en) | 2000-01-12 |
GB2357488A true GB2357488A (en) | 2001-06-27 |
Family
ID=10864645
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9927144A Withdrawn GB2357488A (en) | 1999-11-17 | 1999-11-17 | Capsules by injection moulding |
GB0003304A Withdrawn GB2356842A (en) | 1999-11-17 | 2000-02-15 | Injection-moulded capsules |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0003304A Withdrawn GB2356842A (en) | 1999-11-17 | 2000-02-15 | Injection-moulded capsules |
Country Status (3)
Country | Link |
---|---|
GB (2) | GB2357488A (pl) |
PL (1) | PL197867B1 (pl) |
ZA (1) | ZA200204662B (pl) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2374581A (en) * | 2001-04-20 | 2002-10-23 | Reckitt Benckiser | Water-soluble containers |
GB2383773A (en) * | 2001-10-20 | 2003-07-09 | Henkel Kgaa | Production of filled hollow bodies by rotary-table automatic injection moulding machines |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2252286T3 (es) | 2000-07-14 | 2006-05-16 | Henkel Kommanditgesellschaft Auf Aktien | Cuerpos huecos con compartimentos, que contienen una porcion de detergente textil, de limpieza lavavajillas. |
GB0030436D0 (en) * | 2000-12-13 | 2001-01-24 | Dynamic Products Ltd | A packaging tube |
GB2374582A (en) * | 2001-04-20 | 2002-10-23 | Reckitt Benckiser | Water soluble container containing a composition |
GB2374580B (en) | 2001-04-20 | 2003-07-16 | Reckitt Benckiser | Water-soluble containers |
GB0200154D0 (en) * | 2002-01-04 | 2002-02-20 | Unilever Plc | Fabric conditioning kit |
MXPA05000096A (es) * | 2002-07-03 | 2005-04-11 | Crown Packaging Technology Inc | Recipiente soluble en agua. |
DE10258360A1 (de) * | 2002-12-12 | 2004-06-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel |
US7284553B2 (en) | 2002-12-12 | 2007-10-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient |
DE10300984A1 (de) * | 2003-01-14 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kapsel zur Aufnahme eines inhalativ applizierbaren Wirkstoffs |
US7878193B2 (en) | 2003-01-14 | 2011-02-01 | Boehringer Ingelheim International Gmbh | Capsule for taking an active substance which can be inhaled |
RU2324532C2 (ru) * | 2003-03-22 | 2008-05-20 | Хенкель КГАА | Смешивающее устройство |
MY137973A (en) | 2003-10-31 | 2009-04-30 | Obrist Closures Switzerland | A tamper-evident closure |
WO2005085089A1 (de) * | 2004-03-03 | 2005-09-15 | Henkel Kommanditgesellschaft Auf Aktien | Kosmetische portion |
BRPI0514563A (pt) | 2004-08-23 | 2008-06-17 | Reckitt Benckiser Nv | dispositivo distribuidor de detergente |
US20090170743A1 (en) | 2006-01-21 | 2009-07-02 | Reckitt Benckiser N.V. | Article |
ES2640721T3 (es) | 2006-01-21 | 2017-11-06 | Reckitt Benckiser Finish B.V. | Artículo para su uso en una máquina de lavado de objetos |
GB0608433D0 (en) | 2006-04-28 | 2006-06-07 | Obrist Closures Switzerland | Closure with RFID device |
DE102006021016A1 (de) * | 2006-05-05 | 2007-11-15 | Dürschinger, Günter | Chemisch aktivierbare Kapsel für die Durchgangsprüfung und Behandlung des Darm-Trakts |
GB0621572D0 (en) | 2006-10-30 | 2006-12-06 | Reckitt Benckiser Nv | Multi-dosing detergent delivery device |
GB0621570D0 (en) | 2006-10-30 | 2006-12-06 | Reckitt Benckiser Nv | Multi-dosing detergent delivery device |
GB0621576D0 (en) | 2006-10-30 | 2006-12-06 | Reckitt Benckiser Nv | Device status indicator |
GB2449126A (en) * | 2007-05-11 | 2008-11-12 | Rachael Jayne Pearson | Water soluble hygiene product |
GB0710229D0 (en) | 2007-05-30 | 2007-07-11 | Reckitt Benckiser Nv | Detergent dosing device |
GB2450940B (en) | 2007-07-13 | 2011-11-30 | Obrist Closures Switzerland | Tamper-evident closure |
GB2450939B (en) | 2007-07-13 | 2012-02-01 | Obrist Closures Switzerland | Tamper-Evident closure |
GB0721330D0 (en) | 2007-10-31 | 2007-12-12 | Obrist Closures Switzerland | Tamper Evident closure |
WO2009100306A1 (en) * | 2008-02-08 | 2009-08-13 | Method Products, Inc. | Consumer product packets with enhanced performance |
GB0806190D0 (en) | 2008-04-04 | 2008-05-14 | Obrist Closures Switzerland | A closure |
USD663911S1 (en) | 2009-07-22 | 2012-07-17 | Reckitt Benckiser N.V. | Detergent dispensing device lid |
USD630093S1 (en) | 2010-06-11 | 2011-01-04 | Obrist Closures Switzerland Gmbh | Closure |
ES2877100T3 (es) * | 2011-07-13 | 2021-11-16 | Pharmaxis Ltd | Mejoras relacionadas con los dispositivos de suministro |
ITRM20110594A1 (it) * | 2011-11-10 | 2013-05-11 | Ecopol S P A | Contenitore rigido idrosolubile a rilascio controllato del suo contenuto. |
EP3246000A1 (en) * | 2016-05-18 | 2017-11-22 | Capsugel Belgium NV | Separable capsule for sprinkling applications |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1298084A (en) * | 1968-12-31 | 1972-11-29 | Rech S Et D Applic Scient Et M | Capsules and other self-supporting medicinal packaging means |
DE2333753A1 (de) * | 1973-07-03 | 1975-01-30 | Basf Ag | Freitragende kapsel |
EP0118240A2 (en) * | 1983-02-18 | 1984-09-12 | Warner-Lambert Company | Process for injection moulding starch |
GB2148235A (en) * | 1983-10-20 | 1985-05-30 | Warner Lambert Co | Die pressure moulded capsules |
WO1997017049A1 (en) * | 1995-11-09 | 1997-05-15 | Warner-Lambert Company | Container |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8508173D0 (en) * | 1985-03-28 | 1985-05-01 | Standard Telephones Cables Ltd | Controlled delivery device |
JPH07507564A (ja) * | 1992-09-30 | 1995-08-24 | ファイザー・インク. | コア及び厚さが一定でないコーティングを含有する物品 |
-
1999
- 1999-11-17 GB GB9927144A patent/GB2357488A/en not_active Withdrawn
-
2000
- 2000-02-15 GB GB0003304A patent/GB2356842A/en not_active Withdrawn
- 2000-11-17 PL PL358943A patent/PL197867B1/pl unknown
-
2002
- 2002-06-11 ZA ZA200204662A patent/ZA200204662B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1298084A (en) * | 1968-12-31 | 1972-11-29 | Rech S Et D Applic Scient Et M | Capsules and other self-supporting medicinal packaging means |
DE2333753A1 (de) * | 1973-07-03 | 1975-01-30 | Basf Ag | Freitragende kapsel |
EP0118240A2 (en) * | 1983-02-18 | 1984-09-12 | Warner-Lambert Company | Process for injection moulding starch |
GB2148235A (en) * | 1983-10-20 | 1985-05-30 | Warner Lambert Co | Die pressure moulded capsules |
WO1997017049A1 (en) * | 1995-11-09 | 1997-05-15 | Warner-Lambert Company | Container |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2374581A (en) * | 2001-04-20 | 2002-10-23 | Reckitt Benckiser | Water-soluble containers |
GB2374581B (en) * | 2001-04-20 | 2004-01-28 | Reckitt Benckiser | Water soluble containers |
GB2383773A (en) * | 2001-10-20 | 2003-07-09 | Henkel Kgaa | Production of filled hollow bodies by rotary-table automatic injection moulding machines |
GB2383773B (en) * | 2001-10-20 | 2005-01-26 | Henkel Kgaa | Production of filled hollow bodies by rotary-table automatic injection moulding machines |
Also Published As
Publication number | Publication date |
---|---|
GB9927144D0 (en) | 2000-01-12 |
ZA200204662B (en) | 2004-04-21 |
PL197867B1 (pl) | 2008-05-30 |
GB0003304D0 (en) | 2000-04-05 |
GB2356842A (en) | 2001-06-06 |
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Legal Events
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WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |