GB2208287A - A package permitting the prolonged storage of nutrient products - Google Patents

A package permitting the prolonged storage of nutrient products Download PDF

Info

Publication number
GB2208287A
GB2208287A GB8801163A GB8801163A GB2208287A GB 2208287 A GB2208287 A GB 2208287A GB 8801163 A GB8801163 A GB 8801163A GB 8801163 A GB8801163 A GB 8801163A GB 2208287 A GB2208287 A GB 2208287A
Authority
GB
United Kingdom
Prior art keywords
oxygen
bottle
outer packing
products
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8801163A
Other versions
GB8801163D0 (en
GB2208287B (en
Inventor
Michel Bourguignon
Michel Masson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB8801163D0 publication Critical patent/GB8801163D0/en
Publication of GB2208287A publication Critical patent/GB2208287A/en
Application granted granted Critical
Publication of GB2208287B publication Critical patent/GB2208287B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D79/00—Kinds or details of packages, not otherwise provided for
    • B65D79/02—Arrangements or devices for indicating incorrect storage or transport
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Packages (AREA)
  • Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)

Description

DEVICE PERMITTING THE PROLONGED STORAGE OF NUTRIENT PRO DUCTS The present invention relates to a device permitting the prolonged storage of products contained therein.
More especially, it relates to a device permitting the prolonged preservation of products which must be stored shielded from aerial oxygen.
Among these products, special mention may be made of those intended for enteral nutrition.
These products can contain constituents which are degraded in the presence of aerial oxygen. Constituents such as vitamin C or certain lipids, which are usually present in this type of product, are very rapidly oxidised and hence degraded during prolonged storage in the presence of oxygen.
To pernit prolonged storage of these products intended for enteral nutrition, it has been necessary to develop a packaging capable of preventing the degradation of the said products. For this purpose, packaging in the form of netal cans is frequently employed, since metal cans possess good i.permeabitity to gases.
However, these packagings do not give complete satisfaction to the users, for example those in hospitals. In effect, with this type of packaging, direct visualisation of the level of the product inside the can is impossible, such visualisation being obtainable only by using additionat devices. In point of fact, it is obvious that the abi Lity to monitor readily the Level of a product being ad uinistered to a patient is of great importance.
In an effort to solve this problem, it has also been necessary to take into account the properties of the packaging materials used and the processes applied, as welt as the treatments which the products to be packaged have to undergo, in order to be able to withstand storage.
Taking into account all the requirements of pack-., aging and processes usually employed, the choice of material to be used became directed towards a bottle consisting of a transparent material capable of withst--i'ing a custovary process for sterilisation of the product to be packaged and capable of being easily worked. A material of this kind is, in particular, a thermoplastic material such as low density polyethylene. It may be used alone or in combination with other plastics.
Although a material of this kind satisfies the requirement of transparency and oay be easily worked, it may nevertheless have the disadvantage of being permeable to aerial oxygen.
As a result, the product contained in a bottle of this kind becomes very rapidly degraded on account of the oxidation of its constituents, as already mentioned, in particular, in the case of vitamin C and lipids.
The problem of prolonged storage could hence not be solved by the use of this bottle alone.
r. Among the solutions to this problem which have already bee provided, packagings may be' mentioned 9 ich make use of different mixtures of plastics or different plastirisers which are frequently subjected to special treatmenfs.
Thus, packagings were known which consist, for example, of several superposed layers of different materials or differene mixtures'of materials, each of these layers being endowed with a particular property. One layer may, for example, form a barrier for oxygen, another layer will be the barrier for moisture, and the Like. Te production of such ultilayer packagings often proves intricate and expensive.
In point of fact, the Applicant Company has developed a new packaging device which is simple and cheap to produce and which meets all the requirements needed in order to be able to store a product for a long period without degradation.
The subject of the present patent application is hence a device permitting the prolonged preservation of products which must be stored shielded from aerial oxygen,' characterized in that it consists of: - a bottle whose wall is permeable to aerial oxygen; - an outer packing which encases the said bottle and whos; wall is of low permeability to aerial oxygen; and - an oxygen trap arranged between the outer packing and the bottle. If desired, this device can contain, in addition, an indicator of the presence of oxygen.
The device of the present invention may also be characterized in that: - The bottle designed to receive the product to be stored is made of a transparent thermoplastic material, and in that the said bottle is capable of withstanding a process for sterilisation of the products to be stored.
- The outer packing which encases the container containing the product to be stored is made of a transparent and flexible thermoplastic material.
- This outer packing consists of one or more superposed layers placed under vacuum around the said bottle.
- The oxygen trap is in the form of a sachet and is placed under vacuum between the said bottle and the said outer packing, and consists of a material capable of trapping residual oxygen or oxygen which may have appeared during storage between the bottle and the outer packing..*The presence of this oxygen trap permits stability of the com- ponents that are sensitive to oxidation. It enables, in particular, the vitamin contents to be assured, and prevents the oxidation of fatty acids.
- In cases where it is present, the indicator of the presence of oxygen is also arranged between the outer packing and the bottle.
The device of the invention may also be illustrated, by way of example, by following embodiments: - The transparent thermoplastic material from which the bottle is made is preferably a low- or high-density poiy- ethylene, a polyamide, a polypropylene, a polystyrene, a polycarbonate or a mixture of these products.
- The outer packing encasing the bottle containing the product to be stored preferably consists of 5 to 10 layers of a flexible transparent thermoplastic material such as ethylene vinyl alcohol or polyvinylidene chloride, or a combination of these products.
- The encasing of the said bottle with the said outer packing is accomplished by thermoforming, placing the bottle in position and sealing a film flat against the bottle.
- In cases where, in the device of the invention, an indicator of the presence of oxygen is added, the said indicator is in the form of a capsule containing a material capable of changing its appearance in the presence of oxygen.
- The oxygen trap arranged under vacuum between the bottle and the said outer packing is preferably the product known under the brand name AGELESS Z 50 PU It takes the form of a sachet whose contents trap oxygen.
- The neck of the bottle is made in such a way that it can be connected to a customary system for the discharge and fLow of its contents to the subjects being treated.
- The bottom of the bottle can be equipped with a suspension ring.
- The bottle can be provided with information relating to the product contained therein, in the form of a label or card.
- The bottle can bear a graduation indicating the quantity of product contained.
- The outer packing encasing the bottle containing the product to be stored can be provided with a means, such as a hole or a ring, enabling the assembly to be suspended from a bracket during the administration of the said product.
- The neck of the bottle is equipped during storage with a closure which can be easily removed or pierced so as to make it possible to place in position the customary means permitting the fLow and administration of product from the bottle.
The subject of the invention is also a process for packing products which eust be stored shielded from aerial oxygen. This process comprises filling a bottle whose wall is permeable to oxygen with the said products and enclosing this bottle under vacuum with an outer packing of tow permeability to oxygen, and is characterized in that, during the said encasing, an oxygen trap and, if desired, an indicator of the presence of oxygen are placed between the said bottle and the said outer packing. As a variant of this process, it is also possible -to incorporate a stage of sterilisation of the bottle containing the product to be stored before carrying out the encasing of the said bottle under vacuum without the outer packing.
A non-limiting embodiment of the device of the invent ion is shown in the attached figure.
In this figure: 1 - shows the bottle containing a product which must be stored shielded from aerial oxygen, 2 - the outer packing encasing the bottle, 3 - the oxygen trap, 4 - the indicator of the presence of oxygen, 5 - the indications of the Level of the product in the bottle, 6 - a means of suspension in the form of a hole in the outer packing, 2, provided for hanging the assembly, for example on a bracket, during the administration of the product, 7 - the closure of the neck of the bottle 1, shown schematically, capable of being pierced or removed when a means providing for the flow and administration of the product from the bottle 1 is placed in position, 8 - the fiLm sealed flat against the bottle during the encasing of the bottle 1 with the outer packing.
When the device of the invention is brought into use, the outer packing 2, for example, is torn at the level of the neck of the bottle 1, the closure 7 of the said neck is pierced or removed and a customary device providing for the flow of the product from the bottle 1 and for conveying it to the subject to be treated is then connected.
The assembly is then inverted and suspended, for example from a bracket, and the administration of the product in question is allowed to take place.
The fiLLing of the bottle 1 with the product to be stored and preserved for a long period, as well as the possible sterilisation of the assembly, its encasing under vacuum with the outer packing Z and the placing in position of the oxygen trap 3 and, if desired, an indicator 4 of the presence of oxygen are accompLished according to known processes.
It is self-evident that the invention cannot be limited to the embodiment described and presented. It also encompasses all the possible variants not expressly shown.

Claims (11)

1. Device permitting the prolonged preservation of products which must be stored shielded from aerial oxygen, characterized in that it consists of: - a bottle whose wall is permeable to oxygen, - an outer packing which encases the bottle and whose wall is of low permeability to oxygen, and - an oxygen trap arranged between the outer packing and the bottle.
2. Device permitting the prolonged preservation of products which lust be stored shielded from aerial oxygen, comprising a bottle whose wall is permeable to oxygen, which bottle is encased by an outer packing of low permeability to oxygen and characterized in that an oxygen trap is incorporated between the said bottle and the outer packing.
3. Device according to either of Claims 1 and 2, characterized in that the bottle is made of a transparent thermoplastic material.
4. Device according to any one of Claims 1 to 3, characterized in that the outer packing is made of a transparent and flexible thermoplastic material.
5. Device according to any one of Claims 1 to 4, characterized in that the outer packing consists of one or more superposed layers and is placed under vacuum around the said bottle.
6. Device according to any one of Claims 1 to 5, characterized in that the oxygen trap is in the form of a capsule which has been placed under vacuun between the said bottle and the said outer packing, which capsule consists of a material capable of trapping oxygen which ay have been present or which may have been abLe to appear inside the said outer packing.
7. Device according to any one of Claims 1 to 6, characterized in that it contains an indicator of the presence of oxygen, which is arranged between the bottle and the outer packing.
8. Device permitting the prolonged preservation of products which must be stored shielded from aerial oxygen substantially as herein described with reference to the accompanying drawing.
9. Process for packing products which must be stored shielded from aerial oxygen, the said process comprising filling a bottle whose wall is permeable to oxygen with the said products and encasing this bottle under vacuum with an outer packing of low permeability to oxygen, and characterized in that, during the said encasing, an oxygen trap and, if desired, an indicator of the presence of oxygen are placed between the bottle and the outer packing.
10. Process as claimed in claim 9 substantially as herein described.
11. A product when packed by a process as claimed in claim 9.
GB8801163A 1987-07-30 1988-01-20 Device permitting the prolonged storage of nutrient products Expired - Fee Related GB2208287B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8710793A FR2618762B1 (en) 1987-07-30 1987-07-30 DEVICE FOR THE EXTENDED STORAGE OF NUTRIENT PRODUCTS

Publications (3)

Publication Number Publication Date
GB8801163D0 GB8801163D0 (en) 1988-02-17
GB2208287A true GB2208287A (en) 1989-03-22
GB2208287B GB2208287B (en) 1991-06-26

Family

ID=9353709

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8801163A Expired - Fee Related GB2208287B (en) 1987-07-30 1988-01-20 Device permitting the prolonged storage of nutrient products

Country Status (20)

Country Link
JP (1) JPS6437375A (en)
KR (1) KR890001844A (en)
AT (1) AT393661B (en)
AU (1) AU600079B2 (en)
BE (1) BE1004986A4 (en)
CH (1) CH674972A5 (en)
DE (1) DE3803772C2 (en)
DK (1) DK169380B1 (en)
ES (1) ES2006563A6 (en)
FI (1) FI880236A (en)
FR (1) FR2618762B1 (en)
GB (1) GB2208287B (en)
IT (1) IT1219453B (en)
LU (1) LU87111A1 (en)
NL (1) NL8800279A (en)
NO (1) NO882193L (en)
NZ (1) NZ223331A (en)
PT (1) PT86868B (en)
SE (1) SE8800204L (en)
ZA (1) ZA88520B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0488323A1 (en) * 1990-11-30 1992-06-03 Terumo Kabushiki Kaisha Packaged article
WO1995034488A1 (en) * 1994-06-10 1995-12-21 Smithkline Beecham Plc Package
WO1999036330A1 (en) * 1998-01-16 1999-07-22 Fresenius Kabi Ab Improvements related to containers
WO2003086899A1 (en) * 2002-04-17 2003-10-23 Licher Privatbrauerei Drink packaging and method for producing a drink packaging
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
WO2008037699A1 (en) * 2006-09-27 2008-04-03 Aseptic Technologies S.A. Process for providing an oxygen-free atmosphere within a container
FR2926291A1 (en) * 2008-01-11 2009-07-17 Pharmatop Device, useful for packaging the aqueous formulation of active ingredient sensitive to oxidation, comprises handheld flexible material comprising formulation, overpack containing material, and substance to capture oxygen gas

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10301449A1 (en) * 2003-01-09 2004-07-29 Aesculap Ag & Co. Kg Packing for liquid adhesive has holding chamber for ampoule held under vacuum in relation to initial inside pressure in ampoule, whereby ampoule is constructed so that pressure compensation takes place by holding chamber
KR100799530B1 (en) * 2006-11-16 2008-01-31 주식회사 그라스텍 A non vibration and noise wine-celler
WO2009024946A1 (en) * 2007-08-21 2009-02-26 Ranbaxy Laboratories Limited A packaging kit comprising a light, moisture and/or oxygen sensitive drug
RU2710711C1 (en) * 2018-07-13 2020-01-09 Алексей Владимирович Ковалев Indication device for container

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GB1097637A (en) * 1965-10-21 1968-01-03 American Can Co Package for and method of packaging meats
GB1499852A (en) * 1975-03-04 1978-02-01 Smith & Nephew Pharma Packaging
GB2003821A (en) * 1977-09-06 1979-03-21 Astra Laekemedel Ab Process for prevention of oxidative decomposition
EP0050255A1 (en) * 1980-10-16 1982-04-28 Karl H. Sengewald GmbH & Co. KG Method of packaging parenteral solutions in transparent soft plastics packages suitable for steam sterilisation
GB2119741A (en) * 1982-05-06 1983-11-23 Terumo Corp Package for storage of medical container
GB2119736A (en) * 1982-05-06 1983-11-23 Terumo Corp Package for storage of medical container
EP0109983A1 (en) * 1982-10-30 1984-06-13 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Method for manufacturing plastic container containing infusion solution which does not allow deterioration of infusion solution for long period of time
GB2133018A (en) * 1982-12-20 1984-07-18 El Paso Polyolefins Heat-sterilizable polyolefin compositions and articles manufactured therefrom
GB2180815A (en) * 1985-09-27 1987-04-08 Nissho Kk Radiation-sterilized, packaged medical device

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GB543979A (en) * 1939-12-19 1942-03-23 Stokes Machine Co Improvements in or relating to the packaging and preservation of dried materials
FR1031088A (en) * 1951-01-17 1953-06-19 Desiccant sachets improvements
FR82132E (en) * 1961-06-30 1963-12-27 Huileries Antonin Roux & Savon Packaging intended for the protection of edible oils against oxidation
BE629593A (en) * 1963-02-15
GB1259100A (en) * 1968-07-15 1972-01-05
US4038148A (en) * 1975-12-22 1977-07-26 Marion Laboratories, Inc. Anaerobic environmental system for bacteria culture testing
US4150744A (en) * 1976-02-27 1979-04-24 Smith & Nephew Pharmaceuticals Ltd. Packaging
US4169811A (en) * 1977-03-23 1979-10-02 Mitsubishi Gas Chemical Co., Inc. Oxygen indicator
DE2747810B2 (en) * 1977-10-25 1981-02-19 Bostik Gmbh, 6370 Oberursel Packaging for moisture-sensitive material
SE413304B (en) * 1978-08-25 1980-05-19 Pharmacia Ab pACKING
JPS57206447A (en) * 1981-06-12 1982-12-17 Terumo Corp Plastic container receiving liquid drug pasturized with high pressure steam and production thereof
US4436203A (en) * 1983-05-10 1984-03-13 Joy Research Incorporated Tamper resistant packaging device
DE3524846A1 (en) * 1985-07-12 1987-01-15 Hoechst Ag PACKING FOR DRY RESISTANT MATERIAL
WO1988008694A1 (en) * 1987-05-07 1988-11-17 Terumo Kabushiki Kaisha Packed transfusion
KR910002559B1 (en) * 1987-12-19 1991-04-26 데루모 가부시끼가이샤 Package of medical container

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1097637A (en) * 1965-10-21 1968-01-03 American Can Co Package for and method of packaging meats
GB1499852A (en) * 1975-03-04 1978-02-01 Smith & Nephew Pharma Packaging
GB2003821A (en) * 1977-09-06 1979-03-21 Astra Laekemedel Ab Process for prevention of oxidative decomposition
EP0050255A1 (en) * 1980-10-16 1982-04-28 Karl H. Sengewald GmbH & Co. KG Method of packaging parenteral solutions in transparent soft plastics packages suitable for steam sterilisation
GB2119741A (en) * 1982-05-06 1983-11-23 Terumo Corp Package for storage of medical container
GB2119736A (en) * 1982-05-06 1983-11-23 Terumo Corp Package for storage of medical container
EP0109983A1 (en) * 1982-10-30 1984-06-13 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Method for manufacturing plastic container containing infusion solution which does not allow deterioration of infusion solution for long period of time
GB2133018A (en) * 1982-12-20 1984-07-18 El Paso Polyolefins Heat-sterilizable polyolefin compositions and articles manufactured therefrom
GB2180815A (en) * 1985-09-27 1987-04-08 Nissho Kk Radiation-sterilized, packaged medical device

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0488323A1 (en) * 1990-11-30 1992-06-03 Terumo Kabushiki Kaisha Packaged article
US5217118A (en) * 1990-11-30 1993-06-08 Terumo Kabushiki Kaisha Packaged article
AU642558B2 (en) * 1990-11-30 1993-10-21 Terumo Kabushiki Kaisha Packaged article
WO1995034488A1 (en) * 1994-06-10 1995-12-21 Smithkline Beecham Plc Package
US6050400A (en) * 1994-06-10 2000-04-18 Smithkline Beecham Plc Package
WO1999036330A1 (en) * 1998-01-16 1999-07-22 Fresenius Kabi Ab Improvements related to containers
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
WO2003086899A1 (en) * 2002-04-17 2003-10-23 Licher Privatbrauerei Drink packaging and method for producing a drink packaging
WO2008037699A1 (en) * 2006-09-27 2008-04-03 Aseptic Technologies S.A. Process for providing an oxygen-free atmosphere within a container
FR2926291A1 (en) * 2008-01-11 2009-07-17 Pharmatop Device, useful for packaging the aqueous formulation of active ingredient sensitive to oxidation, comprises handheld flexible material comprising formulation, overpack containing material, and substance to capture oxygen gas

Also Published As

Publication number Publication date
ATA25488A (en) 1991-05-15
AU1092288A (en) 1988-06-23
BE1004986A4 (en) 1993-03-16
DK25888A (en) 1989-01-31
SE8800204L (en) 1989-01-31
SE8800204D0 (en) 1988-01-22
ES2006563A6 (en) 1989-05-01
IT1219453B (en) 1990-05-18
NO882193L (en) 1989-01-31
JPS6437375A (en) 1989-02-08
FI880236A0 (en) 1988-01-20
PT86868A (en) 1989-06-30
NZ223331A (en) 1990-07-26
FR2618762B1 (en) 1989-12-29
GB8801163D0 (en) 1988-02-17
NL8800279A (en) 1988-05-02
IT8847640A0 (en) 1988-02-15
LU87111A1 (en) 1988-05-03
DE3803772A1 (en) 1989-02-09
FI880236A (en) 1989-01-31
CH674972A5 (en) 1990-08-15
DK25888D0 (en) 1988-01-21
AT393661B (en) 1991-11-25
PT86868B (en) 1993-09-30
DE3803772C2 (en) 1996-07-11
GB2208287B (en) 1991-06-26
ZA88520B (en) 1989-03-29
NO882193D0 (en) 1988-05-19
KR890001844A (en) 1989-04-06
DK169380B1 (en) 1994-10-17
AU600079B2 (en) 1990-08-02
FR2618762A1 (en) 1989-02-03

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950120