AU600079B2 - Device permitting the prolonged storage of nutrient products - Google Patents

Device permitting the prolonged storage of nutrient products Download PDF

Info

Publication number
AU600079B2
AU600079B2 AU10922/88A AU1092288A AU600079B2 AU 600079 B2 AU600079 B2 AU 600079B2 AU 10922/88 A AU10922/88 A AU 10922/88A AU 1092288 A AU1092288 A AU 1092288A AU 600079 B2 AU600079 B2 AU 600079B2
Authority
AU
Australia
Prior art keywords
bottle
oxygen
product
casing
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU10922/88A
Other versions
AU1092288A (en
Inventor
Michel Bourguignon
Michel Masson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clintec Nutrition Co
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU1092288A publication Critical patent/AU1092288A/en
Application granted granted Critical
Publication of AU600079B2 publication Critical patent/AU600079B2/en
Assigned to CLINTEC NUTRITION COMPANY reassignment CLINTEC NUTRITION COMPANY Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D79/00—Kinds or details of packages, not otherwise provided for
    • B65D79/02—Arrangements or devices for indicating incorrect storage or transport
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Packages (AREA)
  • Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)

Description

@0o 7,9 Form Australia PATENTS ACT 1952 COMPLETE SPECIFICATION
(ORIGINAL)
FOR OFFICE USE Short Title-, Int. Cl: Apaplication Number; Lodged: 4Complete Specification-Lodged:- Accepted: -0 01 Lapsed:, 0 ~Published, This (hXutnenft contains he aidirieijts made u.nder Sectioni 49 and is correct For printing.
Priority Related Art: TO BF~ COMPLEThO BY APPLICANT N'.ame of Applicant,' Address of Applicant: Actual Inventor: Address for Service:
ROUSSEL-UCLAF
35, Boulevard des Invalides, 75007 Paris, France.
MICHIEL BOURQUIGNON an MICH-EL MASSOtN CALLINANS Pate: nt Attorneys, of 48-50 Bridge Road, Richmond, State of Victoria, Australia.
Comlee pe;Ifcaio fr te nvnton nttld "DEVICE P8RMITTINOI THE PROLONGED STORAGF; Comlee pe~iictln orth ivetin nttld: OF NUTRIENT PRODUCTS" The following statement Is a full description of this Invention, Including the best method of performing It k~nown to me- Note: The description Is to be typed In double spacinig, pia type face, In an area not exceeding 280 mm In depth and 160 mm In width, on tough white paper of good quality and It ls to be Inserted Inside this ftrni.
la The present invention relates to a device permitting the prolonged storage of products contained therein.
More especially, it relates to a device permitting the prolonged preservation of products which must be stored shielded from aerial oxygen.
Among these products, special mention may be made of those intended for enteral nutrition.
Theze products can contain constituents which are degraded in the presence of aerial oxygen. Constituents 1 such as vitamin C or certain lipids, which are usually present in this type of product, are very rapidly oxidised and hence degraded during prolonged storage in the presence of oxygen.
To permit prolonged storage of these products intended for enteral nutrition, it has been necessary to develop a packaging capable of preventing the degradation of S. the said products. For this purpose, packaging in the form of metal cans is frequently employed, since metal cans possess good impermeability to gases.
However, these packagings do not give complete sat- Sisfaction to the users, for example those in hospitals. In effect, with this type of packaging, direct visualisation .o of the level of the product inside the can is impossible, such visualisation being obtainable only by using additional devices. In point of fact, it is obvious that the ability to monitor readily the level of a product being administered to a patient is of great importance.
In an effort to solve this problem, it has also been necessary to take into account the properties of the packaging materials used and the processes applied, as well as the treatments which the products to be packaged have to undergo, in order to be able to withstand storage.
Taking into account all the requirements of packaging and processes usually employed, the choice of material to be used became directed towards a bottle consisting of a transparent material capable of withstan inq a customary process for sterilisation of the product to be i-ir~ -2packaged and capable of being easily worked. A material of this kind is, in particular, a thermoplastic material such as low density polyethylene. It may be used alone or in combination with other plastics.
Although a material of this kind satisfies the requirement of transparency and may be easily worked, it may nevertheless have the disadvantage of being permeable to aerial oxygen.
As a result, the product contained in a bottle of this kind becomes very rapidly degraded on account of the oxidation of its constituents, as already S mentioned, in particular, in the case of vitamin C and lipids.
The problem of prolonged storage could hence not be solved by the use of this bottle alone.
0 o Among the solutions to this problem which have already been provided, packagings may be mentioned which make use of different mixtures of °0"oo plastics or different plasticisers which are frequently subjected to special treatments.
Thus, packaging were known which consist, for example, of several superposed layers of different materials or different mixtures of materials, each of these layers being endowed with a particular property. One layer may, for S example, form a barrier for oxygen, another :'ayer will be the barrier for moisture, and the like. The production of such multilayer packagings often proves intricate and expensive.
In point of fact, the Applicant Company has developed a new S packaging device which is simple and cheap to produce and which meets all the requirements needed in order to be able to store a product for a long period without degradation.
The subject of the present patent application is hence a storage and dispensing device for products required to be shielded from atmospheric oxygen, said device comprising a bottle enclosing said product, the wall of which bottle is oxygen-permeable and is made of a transparent thermoplastic material, an outer casing enclosing the bottle and being arranged so that said product may be dispenised without having to remove said bottle from said casing and comprising at least one superposed layer made of a transparent and flexible thermoplastic material placed under vacuum about the said bottle, the oxygen permeability of said at least one layer being lower than that of said wall, and an oxygen trap arranged in a space between said casing and said wall, said trap being constituted AiThnl by a capsule placed under vacuum in said space, the capsule consisting essentially i -3of a material capable of trapping residual oxygen in said space.
If desired, this device can contain, in addition, an indicator of the presence of oxygen.
The device of the present invention may also be characterized in that: the said bottle is capable of withstanding a process for sterilisation of the products to be stored.
The presence of this oxygen trap permits stability of the components that are sensitive to oxidation, It enables, in particular, the vitamin contents to be assured, and prevents the oxidation of fatty acids.
In cases where it is present, the indicator of the presence of oxygen is also arranged between the outer packing and the bottle.
In contradistinction to prior art, the oxygen trap is separated from the product by the wall of the bottle, thereby reducing risk of contamination or spoilage that might otherwise occur.
The device of the invention may also be illustrated, by way of example, by following embodiments: The transparent thermoplastic material from which the bottle is made is preferably a low- or high-density polyethylene, a polyamide, a polypropylene, a polystyrene, a polycarbonate or a mixture of these products.
i ,20. The outer packing encasing the bottle containing the product to be stored preferably consists of 5 to 10 layers of a flexible transparent thermoplastic material such as ethylene vinyl alcohol or polyvinylidene chloride, or a combination of these products.
The encasing of the said bottle with the said outer packing is accomplished by thermoforming, placing the bottle in position and sealing a film flat against the bottle.
In cases where, in the device of the invention, an indicator of the presence of oxygen is added, the said indicator is in the form of a capsule containing a material capable of changing its appearance in the presence of oxygen.
The oxygen trap arranged under vacuum between the bottle and the said outer packing is preferably the product known under the brand name AGELESS Z PU7.
It takes the form of a sachet whose contents trap oxygen.
The neck of the bottle is made in such a way that it can be connected to a .3 5 custcmary system for the discharge and flow of its contents to the subjects being s- 7 i -4- The bottom of the bottle can be eq'aipped with a suspension ring.
The bottle can be provided with information relating to the product contained therein, in the form of a label or card.
The bottle can bear a graduation indicating the quantity of product contained.
The outer packing encasing the bottle containing the product to be stored can be provided with a means, such as a hole or a ring, enabling the assembly to be suspended from a bracket during the administration of the said product.
The neck of the bottle is equipped during storage with a closure which can be easily removed or pierced so as to make it possible to place in position the 100: customary means permitting the flow and administration of product from the bottle.
The subject of the invention is also a process for packing products 00o0 oo which must be stored shielded from aerial oxygen. This process comprises a process for packing products required to be shielded from atmospheric oxygen, said process comprising filling a bottle, the wall of which is oxygen-permeable and is made of a transparent thermoplastic material, with said product, and enclosing said bottle under vacuum with an outer casing comprising at least one superposed layer made of a transparent and flexible thermoplastic material, the oxygen S permeability of said at least one layer being lower than that of said wall, wherein during said enclosing an oxygen trap constituted by a capsule consisting essentially of a material capable of trapping residual oxygen and, optionally, an indicator of the presence of oxygen, is placed in said space between said wall and 0 said casing, said casing being arranged with respect to said bottle so that said S product may be dispensed from said bottle without having to remove said bottle from said casing. As a variant of this process, it is also possible to incorporate a stage of sterilisation of the bottle containing the product to 4r 4 4? Vt #4 4 It 4 4- 4, 4 S1 *4*~ll 5 be stored before carrying out the encasing of the said bottle under vacuum without the outer packing.
A non-Limiting embodiment of the dpvice of the invention is shown in the attached figure, In this figure: 1 shows the bottle containing a product which must be stored shielded from aerial oxygen, 2 the outer packing encasing the bottle, 3 the oxygen trap, 4 the indicator of the presence of oxygen, 5 the indications of the Level of the product in the bottle, 6 a means of suspension in the form of a hole in the outer packing, 2, provided for hanging the assembly, for example on a bracket, during the administration of the product, 7 the closure of the neck of the bottle 1, shown schematically, capable of being pierced or removed when a means providing for the flow and administration of the product from the bottle 1 is placed in position, 8 the film sealed flat against the bottle during the encasing of the bottle 1 with the outer packing.
When the device of the invention is brought into use, the outer packing 2, for example, is torn at the level of the neck of the bottle 1, the closure 7 of the said neck is pierced or removed and a customary device providing for the flow of the product from the bottle 1 and for conveying it to the subject to the treated is then connected.
The assembly is then inverted and suspended, for example from a bracket, and the administration of the product in question is allowed to take place.
The filling of the bottle 1 with the product to be stored and preserved for a Long period, as well as the possible sterilisation of the assembly, its encasing under vacuum with the outer packing 2 and the placing in position of the oxygen trap 3 and, if desired, an indicator 4 of the presence of oxygen are accomplished according to known processes.
IT~ It is self-evident that the invention cannot be Limited to the embodiment described and presented. It also encompasses all the possible variants not expressly showri.
I*
It

Claims (4)

1. A storage and dispensing device for products required to be shielded from atmospheric oxygen, said device comprising a bottle enclosing said product, She wall of which bottle is oxygen-permeable and is made of a transparent thermoplastic material, an outer casing enclosing the bottle and being arranged so that said product may be dispensed without having to remove said bottle from said casing and comprising at least one superposed layer made of a transparent and S\ flexible thermoplastic material placed under vacuum about the said bottle, the oxygen permeability of said at least one layer being lower than that of said wall, and an oxygen trap arranged in a space between said casing and said wall, said trap being constituted by a capsule placed under vacuum in said space, the capsule consisting essentially of a material capable of trapping residual oxygen in said spce.
2. The device has claimed in Claim 1, wherein said device contains in said space an indicator of the presence of oxygen.
3. A process for packing products required to be shielded from atmospheric oxygen, Isaid process comprising filling a bottle, the wall of which is oxygen-permeable and is made of a transparent thermoplastic material, with said product, and enclosing said bottle under vacuum with an outer casing comprising at leas' one superposed layer made of a transparent and flexible thermoplastic laterial, the oxygen permeability of said at least one layer being lower than that of said wall, wherein 4 .during said enclosing an oxygen trap constituted by a capsule consisting essentially of a material capable of trapping residual oxygen and, optionally, an indicator of the presence of oxygen, is placed in said space between said wall and said casing, said casing being arranged with respect to said bottle so that said product may be dispensed from said bottle without having to remove said bottle from said casing.
4. A device as claimed in either Claim 1 or Claim 2 substantially as hereinbefore disclosed with reference to the drawing. DATED this 24th day of May 1990 ROUSSEL-UCLAF By its Paent Attorneys: CALLINAN LAWRIFR 2 1^1 t 1 Y~"L
AU10922/88A 1987-07-30 1988-01-28 Device permitting the prolonged storage of nutrient products Ceased AU600079B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8710793A FR2618762B1 (en) 1987-07-30 1987-07-30 DEVICE FOR THE EXTENDED STORAGE OF NUTRIENT PRODUCTS
FR8710793 1987-07-30

Publications (2)

Publication Number Publication Date
AU1092288A AU1092288A (en) 1988-06-23
AU600079B2 true AU600079B2 (en) 1990-08-02

Family

ID=9353709

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10922/88A Ceased AU600079B2 (en) 1987-07-30 1988-01-28 Device permitting the prolonged storage of nutrient products

Country Status (20)

Country Link
JP (1) JPS6437375A (en)
KR (1) KR890001844A (en)
AT (1) AT393661B (en)
AU (1) AU600079B2 (en)
BE (1) BE1004986A4 (en)
CH (1) CH674972A5 (en)
DE (1) DE3803772C2 (en)
DK (1) DK169380B1 (en)
ES (1) ES2006563A6 (en)
FI (1) FI880236A (en)
FR (1) FR2618762B1 (en)
GB (1) GB2208287B (en)
IT (1) IT1219453B (en)
LU (1) LU87111A1 (en)
NL (1) NL8800279A (en)
NO (1) NO882193L (en)
NZ (1) NZ223331A (en)
PT (1) PT86868B (en)
SE (1) SE8800204L (en)
ZA (1) ZA88520B (en)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
JP2881662B2 (en) * 1990-11-30 1999-04-12 テルモ株式会社 Package
GB9411626D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Package
WO1999036330A1 (en) * 1998-01-16 1999-07-22 Fresenius Kabi Ab Improvements related to containers
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
DE10217114B4 (en) * 2002-04-17 2004-06-24 Licher Privatbrauerei Ihring-Melchior Gmbh & Co. Kg Beverage packaging and method for producing a beverage packaging
DE10301449A1 (en) * 2003-01-09 2004-07-29 Aesculap Ag & Co. Kg Packing for liquid adhesive has holding chamber for ampoule held under vacuum in relation to initial inside pressure in ampoule, whereby ampoule is constructed so that pressure compensation takes place by holding chamber
GB0619060D0 (en) * 2006-09-27 2006-11-08 Glaxosmithkline Biolog Sa Novel process
KR100799530B1 (en) * 2006-11-16 2008-01-31 주식회사 그라스텍 A non vibration and noise wine-celler
WO2009024946A1 (en) * 2007-08-21 2009-02-26 Ranbaxy Laboratories Limited A packaging kit comprising a light, moisture and/or oxygen sensitive drug
FR2926291A1 (en) * 2008-01-11 2009-07-17 Pharmatop Device, useful for packaging the aqueous formulation of active ingredient sensitive to oxidation, comprises handheld flexible material comprising formulation, overpack containing material, and substance to capture oxygen gas
RU2710711C1 (en) * 2018-07-13 2020-01-09 Алексей Владимирович Ковалев Indication device for container

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AU4099478A (en) * 1977-10-25 1980-05-01 Bostik Australia Pty Ltd Packages
AU5973486A (en) * 1985-07-12 1987-01-15 Morton International, Inc. Package for dry-resist material
AU1044388A (en) * 1987-12-19 1989-07-19 Terumo Kabushiki Kaisha Package of medical container

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JPS58192551A (en) * 1982-05-06 1983-11-10 テルモ株式会社 Package container for preserving medical container
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AU5973486A (en) * 1985-07-12 1987-01-15 Morton International, Inc. Package for dry-resist material
AU1044388A (en) * 1987-12-19 1989-07-19 Terumo Kabushiki Kaisha Package of medical container

Also Published As

Publication number Publication date
ATA25488A (en) 1991-05-15
AU1092288A (en) 1988-06-23
BE1004986A4 (en) 1993-03-16
DK25888A (en) 1989-01-31
SE8800204L (en) 1989-01-31
SE8800204D0 (en) 1988-01-22
ES2006563A6 (en) 1989-05-01
IT1219453B (en) 1990-05-18
NO882193L (en) 1989-01-31
JPS6437375A (en) 1989-02-08
FI880236A0 (en) 1988-01-20
PT86868A (en) 1989-06-30
NZ223331A (en) 1990-07-26
FR2618762B1 (en) 1989-12-29
GB8801163D0 (en) 1988-02-17
NL8800279A (en) 1988-05-02
IT8847640A0 (en) 1988-02-15
LU87111A1 (en) 1988-05-03
DE3803772A1 (en) 1989-02-09
FI880236A (en) 1989-01-31
CH674972A5 (en) 1990-08-15
GB2208287A (en) 1989-03-22
DK25888D0 (en) 1988-01-21
AT393661B (en) 1991-11-25
PT86868B (en) 1993-09-30
DE3803772C2 (en) 1996-07-11
GB2208287B (en) 1991-06-26
ZA88520B (en) 1989-03-29
NO882193D0 (en) 1988-05-19
KR890001844A (en) 1989-04-06
DK169380B1 (en) 1994-10-17
FR2618762A1 (en) 1989-02-03

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