GB2178965A - Devices for administering medicaments to patients - Google Patents
Devices for administering medicaments to patients Download PDFInfo
- Publication number
- GB2178965A GB2178965A GB08618466A GB8618466A GB2178965A GB 2178965 A GB2178965 A GB 2178965A GB 08618466 A GB08618466 A GB 08618466A GB 8618466 A GB8618466 A GB 8618466A GB 2178965 A GB2178965 A GB 2178965A
- Authority
- GB
- United Kingdom
- Prior art keywords
- container
- tray
- plunger
- support
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Description
1 GB 2 178 965 A 1
SPECIFICATION
Devices for administering medicaments to patients This invention relates to devices by which a medicament in solid finely divided form can be administered to or by patients inhaling through the devices. Such devices are now quite well known for administering medicaments contained in capsules to patients suffering from bronchial conditions such as for example, bronchial asthma. It is well known for medicament in powder or other finely divided form to be supplied in capsules which are loaded by a patient into such a device. The medicament is then released from the capsule and inhaled by the patient, usually through the mouth, but sometimes through the nose.
The specification of PCT Application Publication No. W082/01470, GB-A-1 387954 and GB-A-
2061735 all describe devices for dispensing medicament in finely divided form from capsules. In each of these previously described devices, the capsules are mounted on a rotatable support member on which each capsule in turn can be brought to a position in which it is opened to enable medicament to exit from the capsule to permit it to be inhaled by a patient inhaling through a mouthpiece of the device.
There are disadvantages in the use of capsules, which are made of gelatin, to contain medicaments.
Gelatin is relatively unstable and is lacking in physical strength so that the capsules need to be protected by packaging, for example in glass bottles. Environmental degradation of both the capsules and their contents may occur in a relatively short time.
In the device described in UK Patent specification 100
1387954 the capsules are mounted in what is referred to therein as a blister pack, and is in fact a plurality of capsules mounted in a blister pack on a rotor which is designed to spin during exhalation by the patient to throw medicament out of an opened capsule, whereaf- 105 ter the patient inhales. This has a number of disadvantages, including the fact that the exhalation which is required is more difficult for some patients; for example asthma patients, than inhalation.
In our patent specification GB-A-2129691 we provided a more convenient way of administering medicament to such patients than had been possible hitherto and which avoided the need to pack medicaments in capsules. The device there described makes use of the technique of packaging a medicament by 115 loading the medicament directly into a blister pack comprising a sheet, which may be laminated, of foil or plastics material which acts as a carrier and which is provided with a number of breakable or openable containers called -blisters- incorporating a sheet secured on a first sheet to form a cover or lid. Such blister packs are in common use with tablets of one kind or another, but we have discovered that they can also be used with medicaments in finely divided solid form. GB-A-2129691 provides a device for adminis- 125 tering to patients medicaments in blister pack form.
However, the embodiments described in GB-A 2129691 are more bulky than is desirable. It is an object of the present invention to provide a device which avoids or mitigates this problem.
Attention is also directed to our specification
GB-A-2142246 which describes various alternative devices for administering medicaments held in solid finely divided form in blister packs.
According to the present invention there is provided a device for administering medicaments in solid finely divided form to patients, comprising a housing; a tray mounted in the housing and movable between first and second positions relative to the housing; a support provided on the tray and adapted to receive, in use, a carrier provided with at least one medicament con tainer; a plunger operable, in use, to penetrate a container registered therewith to open the container, movement of the tray from its first to its second position being such as to cause in use, the support to bring a container into registration with the plunger; an air inlet through which in use, air can enter the device, and an outlet through which a patient can inhale, whereby medicament will be released from an opened container and entrained in an air flow produced by the patient, air entering the air inlet and passing out through the outlet having entrained medicament therein.
In an embodiment of the invention the support is rotatably mounted on the tray and the carrier has a plurality of medicament containers arranged in a circle. Indexing means are preferably provided so that movement of the tray from its first to its second position causes the support to be indexed to bring the next container into registration with the plunger.
The housing of the device preferably has a base member and a lid pivotally mounted thereon for movement between a closed position and an open position. The plunger can then be carried by the lid and arranged to penetrate a container when the lid is moved to its open position.
The device of the invention is suitable for administering a variety of medicaments such as, for example, salbutamol, beclomethasone dipropionate and sodium cromoglycate.
A significant number of asthma patients suffer from asthma with a severity such that they need to take not one but two medicaments. These are, respectively, a P-stimulant, for example salbutamol or sodium cromoglycate, and an anti - inflammatory steroid, for example beclomethasone dipropionate. Typically a patient needing both these medicaments will take alternate doses of the two medicaments at prescribed intervals during the day.
It is an object of one aspect of the present invention to provide a single device from which two medicaments can be administered. The two medicaments concerned may be a P-stimulant and an anti-inflamatory steroid respectively, or some other pair of medicaments used in treating asthma, or some other pair of medicaments inhaled for the purpose of treating some other condition. The reference to two medicaments is to be understood as including not only a pair of medicaments containing two different active ingredients, but also a pair of medicaments containing the same active ingredient in different dosages.
According to this aspect of the present invention there is provided a device according to the invention in tandem with another such device to form a single article.
2 GB 2178 965 A 2 Some embodiments of the invention are illustrated in the accompanying schematic drawings in which:
Figure 1 is an exploded perspective view of a device according to one embodiment of the invention; Figure 2 is a perspective view of the device of Figure 70 1 with a cover thereof removed:
Figure 3 is a view similar to that of Figure 2 but with a tray portion thereof in an outward position; Figure 4 is a plan view of the device with a portion broken away; Figure 5 is a section taken on line X-X in Figure 4; Figure 6 is a section taken on line Y-Y in Figure 4; Figure 7 is an exploded perspective view of a second embodiment of the invention; Figure 8 is an underplan view of the rotatable support used in the device of Figure 7; Figure 9 is a perspective view of a third embodiment of the invention with the cover removed; Figure 10 is a perspective view of a fourth embodi ment of the invention, for use in dispensing two 85 medicaments; Figure 11 is a perspective view of the article of Figure 10 with a cover thereof removed and with a tray portion thereof in an outward position; Figure 12 is a perspective view of the article of Figure 10 with one of the covers thereof removed and with a lid thereof in a raised position; and Figures 13 to 15 show a fourth embodiment of the invention, also for use in dispensing two medicaments, in positions corresponding to those Figures 10 to 12.
The device shown in Figures 1 to 6 comprise four principal components, namely a housing 1, a tray 2, a rotatable support 3 and a cover 4. The support 3 is designed to receive a circular blister pack 5, as described in more detail below.
Considering first the housing 1, this comprises a base member 10 and a lid 11 hinged thereto by pivots 12. The base member 10 has a base wa 1113, upstanding side and rear walls 14 and 15 and a top wall 16 which extends over only the forward portion of the base member to form a kind of bridge. The top wall 16 has an aperture 17 formed therein. Extending forwardly from the front edge of the lid 11 is an elongated plunger 18. This is so positioned that when the lid 11 is raised the plunger passes through the aperture 17 which also acts as an air inlet into the device. The plunger is conveniently tapered at the tip to form a relatively sharp point, but this is not essential and a blunter plunger would serve the intended purpose which is described below. When the lid is in its lowered position the plunger 18 is protected from damage by upstanding walls 19 formed on the upper wall 16.
The tray 2 defines a shallow chamber 20 for receiving the rotatable support 3. In the centre of the chamber 20 is an upstanding lug 21 on which the support 3 is mounted for rotation. The lug 21 is shown as being cruciform in cross-section, but need not be; a lug of circular cross-section, for example, could be used instead. The tray 2 can be moved in the housing between an inward position, as shown in Figure 2, and an outward position, as shown in Figures 3 and 4.
Further outward movement beyond the above men tioned outward position is normally prevented by a lug 23 which is formed on the end of an arm 22 and 130 which engages behind an inwardly directed protrusion on one of the side walls 14 of the housing 1. The arm 22 is secured to the rest of the tray only at its forward end and is substantially separated from the rest of the tray by a slot 24. The arm 22 is resilient, and when it is desired to remove the tray completely from the housing this can be achieved by pressing the arm 22 inwardly and then withdrawing the tray. Withdrawal is assisted by the provision of thumb grips 33, in the form of ribs, on both sides of the tray. The tray also has a tongue 25 which can be depressed downwardly, as described below, and which has an open slot 26.
Extending from the front of the tray 2 is a mouthpiece 27. It is through this mouthpiece that medicament leaves the device as it is inhaled by a patient. To improve airflow through the mouthpiece it may be provided with a pair of apertures 28. The rotatable support 3 is in the form of a disc in which is formed a circular array of circular openings 30. A central opening 31 enables the carrier to be mounted for rotation on the lug 21. A corresponding plurality of ribs 32 are formed on the underside of the support 3, with one rib extending between each two adjacent openings 30. 90 In use, the cover 4 is removed and the tray with the support 3 mounted thereon, is then removed completely from the housing 1 after the arm 22 has been depressed. A blister pack 5 is then mounted on the support 3 with one blister extending into each of the openings 30. The tray, support and blister pack are then inserted together into the housing. The cover 4 is then replaced. When a patient desires to inhale medicament he removes the cover and raises the lid 11 so as to cause the plunger 18 to pass through the aperture 17 and puncture a respective blister located immediately below the aperture 17. The lid is then lowered to withdraw the plunger from the blister, leaving a hole therein, and the patient inhales the medicament through the mouthpiece 27. It should be noted that the plunger is positively withdrawn from the blister by the patient rather than being left to withdraw under spring pressure (as in GB-A-2129691 mentioned above) which avoids any risk of the plunger remaining jammed in the blister. Either before replacing the cover, or on the next occasion when the patient desires to use the device, the support 3 is rotated to bring the next blister beneath the aperture 17. This is achieved as follows. The tray 2 is withdrawn to its outward position and then pushed back to its inward position. During the latter movement an arm 60 which extends forwardly in the casing 1 and is secured to the base wall 13 thereof engages one of the ribs on the underside of the support 3. This causes the support to rotate in a clockwise direction, as viewed in Figure 4, by an amount sufficient to bring the next blister beneath the aperture 17. During this rotational movement another of the ribs bears against, and progressively depresses, the tongue 25 until that rib engages in the slot 26 which retains the support in its desired position and prevents further rotation. It will be seen from Figure 5 that on either side of the slot 26 are a pair of sloping shoulders, the larger of which prevents anticlockwise rotation of the support 3, and the smaller of which is sufficient to normally retain the rib in the slot 26 but which is not such as to prevent 3 GB 2 178 965 A 3 the rib leaving the slot on the next occasion when the support 3 is rotated as described above.
The upper surface of the blister pack 5 carries a series of numbers, arranged in a circle, corresponding to the number of blisters in the pack (in this case the numbers 1 to 8). The top wall 16 of the housing 1 has an aperture 34 through which a respective one of the numbers is visible to indicate the number of the blister then aligned with the aperture 17, and hence to indicate how many blisters are left for use, or alternatively how many blisters have been used.
In order to assist in providing maximum efficiency of powder entrainment, means are provided for ensuring an air flow patch through the device which is substantially isolated from the surrounding environment. To this end, the tray 2 is provided adjacent the mouthpiece with a pair of upstanding walls 35 which converge towards the centre of the tray, the radially inner ends of the walls 35 being interconnected by a wall 35a. When the support 3 is in a position in which a blister is aligned with the plunger, two adjacent ribs 32 of the support are aligned with the wall 35 and in close contact therewith. Also, the blister pack 5 is in close contact with the underside of the top wall 16 of the tray, at least in the vicinity of the aperture 17. Thus when the patient inhales through the mouthpiece 27 substantially the only air flow which is produced is one which passes through the aperture 17, through the hole formed in the blister alighed therewith, through a chamber defined by the wall 35 and the ribs 32 in contact therewith and thence through the mouthpiece 27, optionally supplemented by air flowing into the mouthpiece through the apertures 28 if these are provided.
There is thus no requirement for airtightness in other 100 parts of the device, for example, airtightness between the housing parts 10 and 11 or between the housing and the tray, and such airtightness is not provided.
Although not visible in the drawings, the device shown in Figures 1 to 6 is preferably provided with a recess, located inwardly of the rear wall 15 and extending parallel thereto, for removably receiving a brush which the patient can use to clean the device of powered medicament spilt therein.
The device shown in Figures 1 to 6 may be modified in various ways. For example, the plunger 18 may be curved, as viewed in side elevation so that as it pierces a blister it produces in it a hole which is smaller and more nearly circular than that which is produced if the plunger is straight as illustrated. This provides for improved entrainment of powdered medicament in the air flow produced by inhalation and helps to avoid powder being trapped in the blister. This and other modifications are shown in Figures 7 and 8 which illustrate a second embodiment of the invention.
The embodiment of Figures 7 and 8 is broadly similar to that of Figures 1 to 6, and the reference numerals in Figures 7 and 8 are the same as in Figures 1 to 6, where appropriate, but with the addition of a prime. Because of the similarities between the two embodiments the following description deals only with features of Figures 7 and 8 which differ from the corresponding features of Figures 1 to 6.
(a) The arm 22 is replaced by a pair of resilient arms 22', one on either side. The symmetry thus achieved makes it easier to slide the tray 2' in and out.
(b) There is no slot 26. 1 nstead, the ribs 32' on the underside of the disc 3' engage behind the rear edge of tongue 25'.
(c) The walls 35 and 35a are replaced by a smoothly continuous wall 35' in which straight wall 35a is replaced by an arcuate wall portion the ends of which merge into the radially inner ends of the walls 35. A corresponding modification is required in the ribs on the underside of the rotatable support, and Figure 8 is an underplan view of such a modified support.
(d) The lug 21' is circular in cross-section, rather than being cruciform as shown in Figure 1.
(e) The thumb grips 33 are replaced by thumb grips 33a' on the arms 22' and additional thumb grips 331b' are provided on the cover 4'.
(f) The aperture 34, through which numbers on the blister pack are visible is replaced by a slot 34'.
Most of the slot is covered by the lid 11', but the forward portion is not, and it is through this forward portion that the numbers are visible.
(g) The brush, which is referred to above but is not shown in Figures 1 to 6 is shown in Figure 7 and denoted by reference numeral 40.
Figure 9 shows a second embodiment of the invention, which instead of using a blister pack comprising a plurality of blisters, uses a plurality of individual packs each containing a single blister. In Figure 9 components which are comparable in function to those of Figures 1 to 6 are denoted by the same reference numerals plus 100.
The device of Figure 9 comprises a housing 101, a tray 102 with an integral support 103, a cover 104, and a plurality of individual blister packs 105. The housing 101 comprises a base member 110 and a lid 111 hinge thereto by pivots 112. The base member 110 includes side walls 114 and a top wall 116 which extends over only the forward portion of the base member to form a kind of bridge. Extending forwardly from the lid 111 is an elongate plunger 118 which is so positioned that when the lid 111 is raised the plunger passes through an aperture 117 formed in the top wall 116. When the lid is in its lowered position the plunger 118 is protected from damage by upstanding walls 119 formed on the top wall 116.
The blister packs are removably contained in a magazine 151 which is fixed or removable and is located at the rear of the housing 101 and normally covered by the lid 111. In the illustrated embodiment the magazine is arranged to contain four packs, but other sizes of magazine could be used instead.
The tray 102 defines a recess 150 adapted to receive one of the blister packs 105. The recess communicates at its forward end with a mouthpiece 127. The tray is slidable between the outward position illustrated and an inward position in which a flange 152 thereof rests against the forward end of the housing 101. Sliding movement is achieved by means of a pair of runners 153 which pass down the inside of the housing adjacent the side walls 114 thereof. The sides of the magazine 151 stop short of the side walls 114 to permit the runners to pass.
In use, the patient removes the cover 104 and, with the tray in either its inward or outward position, raises 4 GB 2 178 965 A 4 the lid 111, and removes a blister pack 105 from the magazine 151. With the tray in its outward position, the patient then places the blister pack on the tray with blister thereof extending downwardly into the recess 150. The lid is then lowered. The tray is then pushed 70 to its inward position and the lid raised to cause the plunger 118 to puncture the blister, and then lowered.
The patient then inhales through the mouthpiece 127, medicament from the blister being entrained in the air flow thus produced. The blister pack is in close 75 contact with the underside of the top wall 116 so that substantially the only air flow is that which passes through the aperture 117; through the hole formed in the blister aligned therewith, through the recess 150 and thence through the mouthpiece 127. If desired, 80 the mouthpiece 127 could be provided with apertures corresponding to the apertures 28 of Figure 1.
The embodiment of Figures 10 to 12 comprises a pair of identical inhalation devices arranged back to back to form a single article. Each device comprises a 85 housing 201, a tray 202, a rotatable support 203 and a cover 204. The support 203 is designed to receive a circular blister pack which, for use in the embodiment illustrated in Figures 10 to 12, comprises four blisters arranged in a circle. It is to be understood, however, 90 that blister packs with other numbers of blisters could be used instead, given appropriate modification to the rotatable support 203.
Considering first the housing 201, this comprises a base member 210 which is common to each of the devices. The housing further comprises a lid 211 hinged to the base member 210 by pivots 212. Each device has its own lid. The lid 211 has a recess 211' in the upper surface thereof, the recess in one side making it easier for a patient to lift the other lid.
The recesses of the two lids are offset from one another on opposite sides of the article. The base member 210 has a base wall (not visible in the drawings), upstanding side walls 214, and a pair of top walls 216, one in each device, each top wall 216 105 being arranged to form a bridge between the side walls. Each top wall 216 has an aperture 217 formed therein. Extending forwardly from the front edge of each lid 211 is an elongate plunger 218. This is so positioned that when the lid 211 is raised (see Figure 110 11) the plunger passes through the aperture 217 which also acts as an air inlet into the device. When the lid is in its lowered position the plunger 218 is protected from damage by upstanding walls 219 formed on the upper wall 216. As can be seen, the plunger 218 is curved, as viewed in side elevation, for reasons set out above.
The tray 202 defines a shallow chamber for receiv ing the rotatable support 203. The tray 202 can be moved in the housing between an inward position, as 120 shown in Figure 12, and an outward position, as shown in Figure 11. Further outward movement beyond the above mentioned outward position is possible only on releasing a lug mechanism which, when released, makes it possible to remove the tray completely from the housing. The lug mechanism can be the same as that described above with reference to Figures 1 to 6; or Figures 7 and 8, and including a lug 23, as are details of the other internal components of the devices, and these are not therefore described in more detail here.
Extending from the front of the tray 202 is a mouthpiece 227. The mouthpiece is provided with a pair of apertures 228, though these are optional.
The remaining constructional details and the manner of use of the devices shown in Figures 10 to 12 can be ascertained from the above description of Figures 1 to 6 and Figures 7 and 8.
It will be apparent that two separate blister packs may be held in the article, one in each of the two devices. These two blister packs may contain different medicaments, and thus a patient needing two different medicaments can use a single article without the problem of needing repeatedly to change over the blister pack from one medicament to the other.
The embodiment shown in Figures 13 to 15 is identical to that shown in Figures 10 to 12 except as regards the lids. In the embodiment of Figures 13 to 15 the lids, denoted by reference numeral 311, each have the general shape of an L, with the stems of the two Us each occupying half the width of the article and being side by side with one another. This makes it possible for the distance between the distal end of each lid and the pivot thereof to be greater than is the case with the embodiment of Figures 10 to 12. This in turn means that for a given upward force applied by the patient to a lid the downward force of the tip of the plunger 218 will be greater in the embodiment of Figures 13 to 15 than it is in the embodiment of Figures 10 to 12. This in turn makes it easier for a patient to puncture a blister, a fact which may be of considerable significance to some patients, particularly the elderly and infirm.
Claims (19)
1. A device for administering medicaments in solid finely divided form to patients, comprising a housing; a tray mounted in the housing and movable between first and second positions relative to the housing; a support provided on the tray and adapted to receive, in use, a carrier provided with at least one medicament container; a plunger operable, in use, to penetrate a container registered therewith to open the container, movement of the tray from its first to its second position being such as to cause, in use, the support to bring a container into registration with the plunger; and air inlet through which, in use, air can enter the device, and an outlet through which a patient can inhale, whereby medicament will be released from an opened container and entrained in an air flow produced by the patient, air entering the air inlet and passing out through the outlet having entrained medicament therein.
2. A device according to claim 1, wherein the support is rotatably mounted on the tray to receive a carrier having a plurality of medicament containers arranged in a circle.
3. A device according to claim 2, wherein indexing means are provided operably by movement of the tray from its first to its second position to cause the support to be indexed to bring the next container into registration with the plunger.
4. A device according to claim 1 or 2, wherein the support is in the form of a disc having a plurality of )c, i 1P GB 2 178 965 A 5 apertures therethrough, the apertures being arranged in a circle so that each receives a respective medicament container.
5. A device according to any one of claims 2 to 4, wherein the plunger is of such a length that it completely penetrates the container aligned therewith to produce an air flow passage therethrough and wherein the support has a plurality of ribs on a face thereof, the ribs cooperating with means provided on the housing adjacent the said outlet to define, together with said passage through the container, a substantially isolated air flow path which leads from the side of the container nearer the plunger, through the container and thence to the said outlet.
6. A device according to claim 1, wherein the support is adapted to receive a carrier having a single medicament container.
7. A device according to claim 6, further comprising a magazine adapted to receive at least one further carrier.
8. A device according to any preceding claim, wherein the housing has a base member and a lid pivotally mounted thereon for pivotal movement about an axis between a closed position and an open position.
9. A device according to claim 8, wherein the said plunger is carried by the lid.
10. A device according to claim 9, wherein the plunger is located adjacent said axis.
11. A device according to claim 9 or 10, wherein the plunger is arranged to penetrate a container when the lid is moved to its open position and to leave the container when the lid is moved from its open position towards its closed position.
12. A device according to anyone of claims 8 to 11, wherein the plunger is curved in a direction such as to reduce the size of hole which it produces in the container on penetration.
13. A device according to any preceding claim, wherein the second tray position is such that the tray moves outwardly with respect to the housing from the first position to the second position and wherein the tray has a third position, outwardly from the second position, in which a carrier can be received by the support.
14. A device according to claim 13, wherein the third tray position is one in which the tray is completely removed from the housing.
15. A device according to any preceding claim, wherein the carrier is a blister pack defining at least one blister as the said container.
16. A device for administering medicaments in finely divided solid form to patients, substantially as herein described with reference to any one of the embodiments shown in Figures 1 to 9 of the accompanying drawings.
17. A device according to anyone of the preceding claims in combination with another such device to form an integral device.
18. A device according to claim 17, wherein said another such device is back-to-back in tandem with the first mentioned device.
19. A device for administering medicaments in finely divided solid form to patients, substantially as herein described with reference to either of the 0 embodiments shown in Figures 10 to 15 of the accompanying drawings.
Printed for Her Majesty's Stationery Office by Croydon Printing Company (UK) Ltd, 12186, D8817356. Published by The Patent Office, 25 Southampton Buildings, London, WC2A l AY, from which copies may be obtained.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858519141A GB8519141D0 (en) | 1985-07-30 | 1985-07-30 | Administering medicaments to patients |
GB858525067A GB8525067D0 (en) | 1985-10-10 | 1985-10-10 | Administering medicaments to patients |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8618466D0 GB8618466D0 (en) | 1986-09-03 |
GB2178965A true GB2178965A (en) | 1987-02-25 |
GB2178965B GB2178965B (en) | 1988-08-03 |
Family
ID=26289568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08618466A Expired GB2178965B (en) | 1985-07-30 | 1986-07-29 | Devices for administering medicaments to patients |
Country Status (35)
Country | Link |
---|---|
US (2) | US4811731A (en) |
EP (1) | EP0211595B1 (en) |
JP (1) | JPS6241668A (en) |
KR (1) | KR940002247B1 (en) |
AT (1) | AT396872B (en) |
AU (1) | AU591152B2 (en) |
BE (1) | BE905189A (en) |
BR (1) | BR8603576A (en) |
CA (1) | CA1272917A (en) |
CH (1) | CH672600A5 (en) |
CY (1) | CY1481A (en) |
DE (2) | DE3682457D1 (en) |
DK (1) | DK163640C (en) |
DO (1) | DOP1989004707A (en) |
ES (1) | ES2000781A6 (en) |
FI (1) | FI88112C (en) |
FR (1) | FR2585563B1 (en) |
GB (1) | GB2178965B (en) |
GR (1) | GR861995B (en) |
HK (1) | HK67589A (en) |
HU (1) | HU199306B (en) |
IE (1) | IE59026B1 (en) |
IL (1) | IL79550A (en) |
IT (1) | IT1195984B (en) |
KE (1) | KE3865A (en) |
LU (1) | LU86534A1 (en) |
MX (1) | MX171389B (en) |
NL (1) | NL8601949A (en) |
NO (1) | NO166268C (en) |
NZ (1) | NZ217006A (en) |
PH (1) | PH26882A (en) |
PL (1) | PL149733B1 (en) |
PT (1) | PT83094B (en) |
SE (1) | SE8603252L (en) |
SG (1) | SG8789G (en) |
Cited By (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5035237A (en) * | 1985-07-30 | 1991-07-30 | Newell Robert E | Devices for administering medicaments to patients |
GB2246299A (en) * | 1990-06-08 | 1992-01-29 | Glaxo Group Ltd | Medicament-containing article and device therefor. |
GB2264237A (en) * | 1992-02-05 | 1993-08-25 | Robert Edward Newell | An inhaler |
US5320095A (en) * | 1990-12-10 | 1994-06-14 | Pharmachemie B.V. | Device for use with the inhalation of powdered materials contained in rod-shaped capsules |
US5337740A (en) * | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
US5673686A (en) * | 1994-02-02 | 1997-10-07 | Plurichemie Anstalt | Medicament inhaler and method |
US5778873A (en) * | 1992-02-21 | 1998-07-14 | Innovata Biomed Limited | Metering device for use in transferring a desired volumetric dose of a flowable substance from a storage container |
US5794613A (en) * | 1997-01-09 | 1998-08-18 | Sepracor, Inc. | Multiple-dose dispenser for dry powder inhalers |
EP0938907A1 (en) | 1996-01-03 | 1999-09-01 | Glaxo Group Limited | Inhalation device |
WO2002012266A1 (en) | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
WO2005046586A2 (en) | 2003-11-04 | 2005-05-26 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
WO2005104745A2 (en) | 2004-04-27 | 2005-11-10 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7045658B2 (en) | 2001-03-22 | 2006-05-16 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
WO2006104889A2 (en) | 2005-03-25 | 2006-10-05 | Glaxo Group Limited | Novel compounds |
US7135600B2 (en) | 2001-02-14 | 2006-11-14 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7271197B2 (en) | 2002-04-25 | 2007-09-18 | Glaxo Group Limited | Phenethanolamine derivatives |
US7294650B2 (en) | 2003-12-17 | 2007-11-13 | Glaxo Group Limited | Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders |
US7361787B2 (en) | 2001-09-14 | 2008-04-22 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7384946B2 (en) | 2004-03-17 | 2008-06-10 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
US7402598B2 (en) | 2002-07-25 | 2008-07-22 | Glaxo Group Limited | Arylethanolamine β2-adrenoreceptor agonist compounds |
WO2008118724A1 (en) | 2007-03-23 | 2008-10-02 | Smithkline Beecham Corporation | Indole carboxamides as ikk2 inhibitors |
US7442839B2 (en) | 2002-10-28 | 2008-10-28 | Glaxo Group Limited | Phenethanolamine derivative for the treatment of respiratory diseases |
US7495010B2 (en) | 2003-07-17 | 2009-02-24 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7507747B2 (en) | 2003-10-17 | 2009-03-24 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
EP2039700A2 (en) | 2001-04-30 | 2009-03-25 | Glaxo Group Limited | Novel anti-inflammatory androstane derivatives |
US7538127B2 (en) | 2003-02-14 | 2009-05-26 | Glaxo Group Limited | Medicinal compounds |
US7576096B2 (en) | 2003-10-14 | 2009-08-18 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7598267B2 (en) | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7767691B2 (en) | 2005-08-18 | 2010-08-03 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system |
US7846973B2 (en) | 2004-04-02 | 2010-12-07 | Theravance, Inc. | Chemical process and new crystalline form |
WO2010147947A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF |
US7956065B2 (en) | 2008-09-08 | 2011-06-07 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compounds |
EP2363121A1 (en) | 2002-02-04 | 2011-09-07 | Glaxo Group Limited | Pharmaceutical formulation for administration by inhalation comprising an androstane derivative and a beta-2-adrenoreceptor agonist for the treatment of inflammatory and allergic conditions |
US8109267B2 (en) | 2006-05-16 | 2012-02-07 | Hovione International Ltd. | Simple inhaler |
WO2012028663A1 (en) | 2010-08-31 | 2012-03-08 | Glaxo Group Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
WO2012028662A1 (en) | 2010-08-31 | 2012-03-08 | Glaxo Group Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
EP2436686A1 (en) | 2005-03-25 | 2012-04-04 | Glaxo Group Limited | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator |
US8205614B2 (en) | 1999-09-04 | 2012-06-26 | Innovata Biomed Limited | Delivery device |
US8337816B2 (en) | 2001-09-17 | 2012-12-25 | Glaxo Group Limited | Dry powder medicament formulations |
WO2013045431A1 (en) | 2011-09-27 | 2013-04-04 | Glaxo Group Limited | Sulfonamide compounds and their use in the modulation retinoid - related orphan receptor |
US8511302B2 (en) | 2004-04-24 | 2013-08-20 | Innovata Biomed Limited | Dose counter mechanisms for medicament delivery devices |
WO2013160418A1 (en) | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
WO2013160419A1 (en) | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
WO2014085474A1 (en) | 2012-11-28 | 2014-06-05 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
US8800550B2 (en) | 2001-11-23 | 2014-08-12 | Innovata Biomed Limited | Medicament delivery assembly |
US8851069B2 (en) | 2004-04-21 | 2014-10-07 | Innovata Biomed Limited | Inhaler |
US9297813B2 (en) | 2010-11-11 | 2016-03-29 | Agency For Science, Technology And Research | Targeting metabolic enzymes in human cancer |
US9365905B2 (en) | 2005-02-10 | 2016-06-14 | Dmv-Fonterra Excipients Technology Gmbh | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
WO2016142426A1 (en) | 2015-03-11 | 2016-09-15 | Glaxosmithkline Intellectual Property Development Limited | Tslp binding proteins |
WO2016203400A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
WO2016203401A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
WO2017029602A2 (en) | 2015-08-16 | 2017-02-23 | Glaxosmithkline Intellectual Property Development Limited | Compounds for use in antibacterial applications |
WO2017060854A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
WO2017060855A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
WO2018055527A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018055524A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018055526A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018104766A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators |
WO2018109642A1 (en) | 2016-12-12 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
WO2018109643A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as nrf2 acti |
WO2018109648A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | 3-oxo-1,4-diazepinyle compounds as nrf2 activators |
WO2018109649A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Ether linked triazoles as nrf2 regulators |
WO2018109647A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl amides as nrf2 regulators |
WO2018109641A1 (en) | 2016-12-12 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | 3-carboxylic acid pyrroles as nrf2 regulators |
WO2018109646A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 compounds |
WO2019115640A1 (en) | 2017-12-15 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | 6-(morpholin-4-yl)-pyridin-2-yl-1h-pyrrolo[3,2-b]pyridine derivatives as m-tor inhibitors |
WO2019116230A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
WO2019116231A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
WO2019141694A1 (en) | 2018-01-17 | 2019-07-25 | Glaxosmithkline Intellectual Property Development Limited | Pi4kiiibeta inhibitors |
WO2019224667A1 (en) | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Indanes as nrf2 activators |
WO2020023813A1 (en) | 2018-07-27 | 2020-01-30 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
WO2020055858A1 (en) | 2018-09-10 | 2020-03-19 | Cocrystal Pharma, Inc. | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication |
WO2020102270A1 (en) | 2018-11-13 | 2020-05-22 | Cocrystal Pharma, Inc. | Formulations of influenza therapeutics |
WO2020112716A1 (en) | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
WO2020249652A1 (en) | 2019-06-13 | 2020-12-17 | Glaxosmithkline Intellectual Property Development Limited | Pyridyl or pyrimidyl mtor kinase inhibitors |
EP3782996A1 (en) | 2015-06-15 | 2021-02-24 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
US11014941B2 (en) | 2017-04-24 | 2021-05-25 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
US11090294B2 (en) | 2009-12-01 | 2021-08-17 | Glaxo Group Limited | Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist |
US11116721B2 (en) | 2009-02-26 | 2021-09-14 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl) phenol |
WO2021206876A1 (en) | 2020-04-10 | 2021-10-14 | Cocrystal Pharma, Inc. | Inhibitors of norovirus and coronavirus replication |
WO2021216547A1 (en) | 2020-04-20 | 2021-10-28 | Sorrento Therapeutics, Inc. | Pulmonary administration of ace2 polypeptides |
WO2022175425A1 (en) | 2021-02-22 | 2022-08-25 | Glaxosmithkline Intellectual Property Development Limited | Inhaled mtor kinase inhibitors for use in the treatment or the prevention of a respiratory rna virus infection |
WO2022179967A1 (en) | 2021-02-23 | 2022-09-01 | Glaxosmithkline Intellectual Property (No.2) Limited | Vadadustat for treating covid-19 in a hospitalized subject |
Families Citing this family (430)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1222509B (en) * | 1987-08-17 | 1990-09-05 | Miat Spa | INSUFFLATOR FOR THE ADMINISTRATION OF DRUGS IN THE FORM OF PRE-DOSED POWDER IN OPERATIONS |
US4817789A (en) * | 1987-09-23 | 1989-04-04 | Allergan, Inc. | Lens container assembly |
FR2626500B1 (en) * | 1988-01-28 | 1990-04-27 | Valois Sa | VAPOR PUSH BUTTON AGENCY FOR MIXING AN ADDITIVE IN THE EMISSION OF THE JET |
CH678151A5 (en) * | 1988-07-13 | 1991-08-15 | Heinz Hermann Weick | Self-medication nasal dispenser |
GB8824804D0 (en) * | 1988-10-22 | 1988-11-30 | Fisons Plc | Device |
SE466684B (en) * | 1989-03-07 | 1992-03-23 | Draco Ab | DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION |
US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
US5239991A (en) * | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
IT1230313B (en) * | 1989-07-07 | 1991-10-18 | Somova Spa | INHALER FOR CAPSULES MEDICATIONS. |
DE3927170A1 (en) * | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | INHALATOR |
US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
DK544589D0 (en) * | 1989-11-01 | 1989-11-01 | Novo Nordisk As | MANUALLY OPERATED DEVICE FOR DISPENSING A PRESCRIBED QUANTITY OF A POWDER-SHAPED SUBSTANCE |
HU213221B (en) | 1990-03-02 | 1997-03-28 | Glaxo Group Ltd | Inhalation device and medicine packet for device |
GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
MY105368A (en) | 1990-03-02 | 1994-09-30 | Glaxo Group Ltd | Inhalation device. |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
GB9015522D0 (en) * | 1990-07-13 | 1990-08-29 | Braithwaite Philip W | Inhaler |
IT1243344B (en) * | 1990-07-16 | 1994-06-10 | Promo Pack Sa | MULTI-DOSE INHALER FOR POWDER MEDICATIONS |
SE9002895D0 (en) * | 1990-09-12 | 1990-09-12 | Astra Ab | INHALATION DEVICES FOR DISPENSING POWDERS I |
US5429122A (en) * | 1990-09-26 | 1995-07-04 | Zanen; Pieter | Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber |
FR2667509B1 (en) * | 1990-10-04 | 1995-08-25 | Valois | POWDER INHALER, DEVICE FOR PACKAGING POWDER MICRODOSES IN THE FORM OF BANDS SUITABLE FOR USE IN A POWDER INHALER, AND METHOD FOR MANUFACTURING SUCH BANDS. |
US5243970A (en) * | 1991-04-15 | 1993-09-14 | Schering Corporation | Dosing device for administering metered amounts of powdered medicaments to patients |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6681767B1 (en) | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
AU662919B2 (en) * | 1991-07-02 | 1995-09-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5287850A (en) * | 1991-08-20 | 1994-02-22 | Habley Medical Technology Corporation | Timing and velocity controlled powered pharmaceutical inhaler |
DE4128295A1 (en) * | 1991-08-27 | 1993-03-04 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
GB9124468D0 (en) * | 1991-11-18 | 1992-01-08 | Smithkline Beecham Plc | Novel device |
DE4211475A1 (en) * | 1991-12-14 | 1993-06-17 | Asta Medica Ag | POWDER INHALATOR |
EP0558879B1 (en) * | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
US5301664A (en) * | 1992-03-06 | 1994-04-12 | Sievers Robert E | Methods and apparatus for drug delivery using supercritical solutions |
JPH0633935Y2 (en) * | 1992-03-27 | 1994-09-07 | サカセ化学工業株式会社 | Grouping Medicine Pool |
AU686560B2 (en) * | 1992-05-29 | 1998-02-12 | Pulmotec Gmbh | Device for generating inhalable active substance particles |
US5394868A (en) * | 1992-06-25 | 1995-03-07 | Schering Corporation | Inhalation device for powdered medicaments |
US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US7448375B2 (en) * | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
NZ262807A (en) * | 1993-03-03 | 1997-11-24 | Glaxo Wellcome Inc | Inhalator; medicament carrier for dry powder inhalator has a portion with a plurality of interstices, for a predetermined dose |
TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5372128A (en) * | 1993-04-14 | 1994-12-13 | Habley Medical Technology Corporation | Fluidizing powder inhaler |
US5533502A (en) * | 1993-05-28 | 1996-07-09 | Vortran Medical Technology, Inc. | Powder inhaler with aerosolization occurring within each individual powder receptacle |
BE1007408A3 (en) * | 1993-08-13 | 1995-06-06 | Winters Joep | Method and device for checking medicine intake |
US5524613A (en) * | 1993-08-25 | 1996-06-11 | Habley Medical Technology Corporation | Controlled multi-pharmaceutical inhaler |
US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
DK0748213T3 (en) * | 1994-03-07 | 2004-08-02 | Nektar Therapeutics | Methods and compositions for pulmonary administration of insulin |
US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
JPH10500672A (en) * | 1994-05-18 | 1998-01-20 | インヘイル セラピューティック システムズ,インコーポレイティド | Methods and compositions relating to dry powder formulations of interferon |
US5483954A (en) * | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
EP0846009B1 (en) | 1994-09-21 | 2008-03-05 | Nektar Therapeutics | Apparatus and method for dispersing dry powder medicaments |
FR2725626A1 (en) * | 1994-10-18 | 1996-04-19 | Sofab | DEVICE FOR INHALING POWDERED PRODUCTS |
DE19500764C2 (en) * | 1995-01-13 | 2001-09-27 | Sofotec Gmbh & Co Kg | Device for administering medication in solid form, finely distributed in an air stream |
US5676643A (en) * | 1995-02-13 | 1997-10-14 | The Procter & Gamble Company | Dispenser for friably releasing dry particulate medicaments |
US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
US5669973A (en) * | 1995-06-06 | 1997-09-23 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing and retaining materials upon a substrate |
US5714007A (en) | 1995-06-06 | 1998-02-03 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate |
US20040237961A1 (en) * | 1995-06-08 | 2004-12-02 | Snow John Medlin | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US6672304B1 (en) | 1995-06-08 | 2004-01-06 | Innovative Devices, Llc | Inhalation actuated device for use with metered dose inhalers (MDIs) |
DE19523516C1 (en) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhaler for administering medication from blister packs |
US5642727A (en) * | 1995-07-25 | 1997-07-01 | David Sarnoff Research Center, Inc. | Inhaler apparatus using a tribo-electric charging technique |
US5988163A (en) * | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
NL1001031C1 (en) * | 1995-08-23 | 1997-02-25 | Npk Ind Design B V | Device for dispensing pills from a blister pack. |
US5649554A (en) * | 1995-10-16 | 1997-07-22 | Philip Morris Incorporated | Electrical lighter with a rotatable tobacco supply |
US5827985A (en) * | 1995-12-19 | 1998-10-27 | Endress + Hauser Gmbh + Co. | Sensor apparatus for process measurement |
US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
USD381416S (en) * | 1996-02-08 | 1997-07-22 | Astra Aktiebolag | Unit dose inhaler |
US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
GB9610821D0 (en) * | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
US5857456A (en) * | 1996-06-10 | 1999-01-12 | Sarnoff Corporation | Inhaler apparatus with an electronic means for enhanced release of dry powders |
US5871010A (en) | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
GB9616047D0 (en) | 1996-07-31 | 1996-09-11 | Glaxo Group Ltd | Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof |
JP2001507700A (en) | 1996-12-31 | 2001-06-12 | インヘイル・セラピューティック・システムズ | Hydrophobic aerosol drug |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
TW469832U (en) * | 1997-03-14 | 2001-12-21 | Astra Ab | Inhalation device |
US6006747A (en) * | 1997-03-20 | 1999-12-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
US6237590B1 (en) * | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
AU139218S (en) * | 1997-10-22 | 1999-12-15 | Procter & Gamble | Dispenser with cap |
CN1301185A (en) * | 1997-12-02 | 2001-06-27 | 杜兰药品公司 | Dry powder inhaler |
US6116238A (en) * | 1997-12-02 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6237591B1 (en) | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
WO1999047196A1 (en) * | 1998-03-16 | 1999-09-23 | Inhale Therapeutic Systems, Inc. | Aerosolized active agent delivery |
DE19817417A1 (en) | 1998-04-18 | 1999-10-21 | Pfeiffer Erich Gmbh & Co Kg | Dispenser for media, especially powder |
US6257233B1 (en) * | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
US6149774A (en) | 1998-06-10 | 2000-11-21 | Delsys Pharmaceutical Corporation | AC waveforms biasing for bead manipulating chucks |
DE19831525A1 (en) * | 1998-07-14 | 2000-01-20 | Pfeiffer Erich Gmbh & Co Kg | Media Donor |
KR100522910B1 (en) * | 1998-09-15 | 2005-12-21 | 주식회사 새 한 | Manufacturing method of polyester flammable fabric with excellent refreshing feeling |
UA73924C2 (en) * | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
US6923979B2 (en) * | 1999-04-27 | 2005-08-02 | Microdose Technologies, Inc. | Method for depositing particles onto a substrate using an alternating electric field |
IL146886A0 (en) * | 1999-06-05 | 2002-08-14 | Innovata Biomed Ltd | Medicament delivery system |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6606992B1 (en) * | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US6730066B1 (en) * | 1999-08-03 | 2004-05-04 | Pharmacia Ab | Liquid delivery container |
GB9924415D0 (en) * | 1999-10-16 | 1999-12-15 | Glaxo Group Ltd | Medicament pack |
AU1752601A (en) * | 1999-11-11 | 2001-06-06 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6679256B2 (en) | 1999-12-17 | 2004-01-20 | Nektar Therapeutics | Systems and methods for extracting powders from receptacles |
MY136453A (en) * | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
US6883516B2 (en) | 2000-04-27 | 2005-04-26 | Chrysalis Technologies Incorporated | Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution |
US6948494B1 (en) | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
GB0015034D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Inhalation device |
TWI224515B (en) * | 2000-06-23 | 2004-12-01 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
US7575761B2 (en) * | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
EP1172122A1 (en) * | 2000-07-14 | 2002-01-16 | The Technology Partnership Public Limited Company | Dry powder inhaler |
US6948492B2 (en) * | 2000-08-15 | 2005-09-27 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
SE517229C2 (en) * | 2000-09-25 | 2002-05-14 | Microdrug Ag | Continuous dry powder inhaler |
GB0023654D0 (en) | 2000-09-27 | 2000-11-08 | Cambridge Consultants | Device for administering doses of particulate material |
US6595210B2 (en) | 2000-11-27 | 2003-07-22 | Unisia Jecs Corporation | Inhalator for administering powder composition |
US6701921B2 (en) * | 2000-12-22 | 2004-03-09 | Chrysalis Technologies Incorporated | Aerosol generator having heater in multilayered composite and method of use thereof |
US6501052B2 (en) | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
US7077130B2 (en) | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
US6491233B2 (en) | 2000-12-22 | 2002-12-10 | Chrysalis Technologies Incorporated | Vapor driven aerosol generator and method of use thereof |
US6799572B2 (en) | 2000-12-22 | 2004-10-05 | Chrysalis Technologies Incorporated | Disposable aerosol generator system and methods for administering the aerosol |
US6681998B2 (en) | 2000-12-22 | 2004-01-27 | Chrysalis Technologies Incorporated | Aerosol generator having inductive heater and method of use thereof |
DE60221640T2 (en) * | 2001-02-06 | 2008-05-21 | Innovata Biomed Ltd., St. Albans | BIMODAL DRY POWDER COMPOSITION FOR INHALATION |
WO2002092154A1 (en) | 2001-04-26 | 2002-11-21 | New England Pharmaceuticals, Inc. | Metered dose delivery device for liquid and powder agents |
US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US6540081B2 (en) * | 2001-09-06 | 2003-04-01 | Ecolab Inc. | Unit dose blister pack product dispenser |
WO2003024514A1 (en) | 2001-09-19 | 2003-03-27 | Advent Pharmaceuticals Pty Ltd | An inhaler |
US6640050B2 (en) | 2001-09-21 | 2003-10-28 | Chrysalis Technologies Incorporated | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
US6568390B2 (en) | 2001-09-21 | 2003-05-27 | Chrysalis Technologies Incorporated | Dual capillary fluid vaporizing device |
US7931022B2 (en) * | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
US20030094173A1 (en) * | 2001-11-14 | 2003-05-22 | Inhale Therapeutic Systems, Inc. | Aerosolization device with improved endpiece connection |
US6804458B2 (en) | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
US6681769B2 (en) | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
US20030168057A1 (en) * | 2001-12-14 | 2003-09-11 | Inhale Therapeutic Systems, Inc. | Electronically controllable aerosol delivery |
US6701922B2 (en) | 2001-12-20 | 2004-03-09 | Chrysalis Technologies Incorporated | Mouthpiece entrainment airflow control for aerosol generators |
US7458373B2 (en) * | 2002-01-15 | 2008-12-02 | Philip Morris Usa Inc. | Aerosol generator for drug formulation |
EP1467790A1 (en) * | 2002-01-25 | 2004-10-20 | Glaxo Group Limited | Medicament dispenser |
GB0217199D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
GB0201677D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
EP1507583A1 (en) * | 2002-03-01 | 2005-02-23 | Glaxo Group Limited | Rotary blending apparatus and system |
US7794965B2 (en) | 2002-03-13 | 2010-09-14 | Signum Biosciences, Inc. | Method of identifying modulators of PP2A methylase |
DE10212264A1 (en) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament |
AU2003220125B2 (en) | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
JP2006504446A (en) * | 2002-03-26 | 2006-02-09 | グラクソ グループ リミテッド | Method for forming laminate assembly and product formed thereby |
GR1004350B (en) * | 2002-03-29 | 2003-09-26 | Inhaler for dry powder | |
US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
DE10216429A1 (en) | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Synergistic medicaments for treating inflammatory or obstructive respiratory tract diseases, containing quaternized scopine ester anticholinergic agent and steroid, e.g. budesonide |
GB0208609D0 (en) * | 2002-04-13 | 2002-05-22 | Glaxo Group Ltd | Compositions |
GB0208608D0 (en) * | 2002-04-13 | 2002-05-22 | Glaxo Group Ltd | Composition |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
AU2003228683A1 (en) * | 2002-04-25 | 2003-11-10 | Glaxo Group Limited | Magnetoacoustic sensor system and associated method for sensing environmental conditions |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
US6854461B2 (en) * | 2002-05-10 | 2005-02-15 | Philip Morris Usa Inc. | Aerosol generator for drug formulation and methods of generating aerosol |
US7089786B2 (en) * | 2002-05-15 | 2006-08-15 | Glaxo Group Limited | Microelectromechanical system and method for determining temperature and moisture profiles within pharmaceutical packaging |
US7185651B2 (en) * | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
DE10230751A1 (en) | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New drug compositions based on new anticholinergics and EGFR kinase inhibitors |
EP1707205A2 (en) | 2002-07-09 | 2006-10-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
GB0217196D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
EP1534367A1 (en) * | 2002-07-25 | 2005-06-01 | Glaxo Group Limited | Medicament dispenser |
GB0217198D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
JP2005533582A (en) * | 2002-07-25 | 2005-11-10 | グラクソ グループ リミテッド | Drug dispenser |
AU2003270321B2 (en) * | 2002-09-06 | 2008-04-03 | Philip Morris Products S.A. | Aerosol generating devices and methods for generating aerosols having controlled particle sizes |
US20070139442A1 (en) * | 2002-09-13 | 2007-06-21 | Robinson Karl E | Coated blending system |
US6962266B2 (en) * | 2002-10-04 | 2005-11-08 | Ecolab Inc. | Method and apparatus for using a unit dose dispenser |
EP1554264B1 (en) * | 2002-10-22 | 2007-08-08 | Glaxo Group Limited | Medicinal arylethanolamine compounds |
US6772757B2 (en) | 2002-10-25 | 2004-08-10 | Chrysalis Technologies Incorporated | Concentric controlled temperature profile fluid vaporizing device |
US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
WO2004060260A2 (en) * | 2002-12-18 | 2004-07-22 | Glaxo Group Limited | Drug delivery system with vented mouthpiece |
US6941947B2 (en) * | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
WO2004066912A2 (en) * | 2003-01-31 | 2004-08-12 | Technion Research & Development Foundation Ltd. | Anti-inflammatory compositions and uses thereof |
WO2004071527A1 (en) * | 2003-02-11 | 2004-08-26 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on anticholinergics and anti-tnf antibodies |
EP1594528A1 (en) * | 2003-02-11 | 2005-11-16 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions based on anticholinergics and soluble tnf receptor fusion proteins |
PE20040950A1 (en) | 2003-02-14 | 2005-01-01 | Theravance Inc | BIPHENYL DERIVATIVES AS AGONISTS OF ß2-ADRENERGIC RECEPTORS AND AS ANTAGONISTS OF MUSCARINAL RECEPTORS |
DE10317461A1 (en) | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt |
US20040245279A1 (en) * | 2003-05-05 | 2004-12-09 | Bradley Tareasa L. | System for dispensing an active ingredient using a dispensable tablet, dispensable tablet and container for holding such dispensable tablets |
TW200510298A (en) | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
EP1488819A1 (en) * | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
GB0316335D0 (en) * | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Pharmaceutical formulations |
GB0317374D0 (en) | 2003-07-24 | 2003-08-27 | Glaxo Group Ltd | Medicament dispenser |
RU2375059C2 (en) | 2003-07-29 | 2009-12-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Inhalation medicines containing beta-memetics and anticholinergic agent |
US7367334B2 (en) | 2003-08-27 | 2008-05-06 | Philip Morris Usa Inc. | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
US6991131B2 (en) * | 2003-09-02 | 2006-01-31 | Ecolab, Inc. | Distributable container and system and method using distributable container |
US7686016B2 (en) | 2003-09-24 | 2010-03-30 | Medi-Stream Pty Ltd Acn 111 815 715 | Medication holder |
AU2004273547B2 (en) * | 2003-09-24 | 2006-07-06 | Tianda Pharmaceuticals (Australia) Pty Ltd | Medication holder |
GB2407042B (en) | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
GB0324654D0 (en) * | 2003-10-22 | 2003-11-26 | Glaxo Group Ltd | Medicinal compounds |
GB0324886D0 (en) * | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Medicinal compounds |
GB0324897D0 (en) * | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Composition |
US20070277820A1 (en) * | 2003-10-27 | 2007-12-06 | Timothy Crowder | Blister packages and associated methods of fabricating dry powder drug containment systems |
EP1686960A4 (en) * | 2003-10-28 | 2007-03-07 | Glaxo Group Ltd | Inhalable pharmaceutical formulations employing lactose anhydrate and methods of administering the same |
EP2083007B1 (en) | 2003-11-03 | 2013-04-24 | Boehringer Ingelheim International Gmbh | Tiotropium salts, method for creating same and medicinal formulations containing same |
CN102070630B (en) | 2003-11-03 | 2013-04-17 | 贝林格尔.英格海姆国际有限公司 | New tiotropium salts, pharmaceutical compositions containing the same and use thereof |
GB0325627D0 (en) * | 2003-11-03 | 2003-12-10 | Glaxo Group Ltd | A hand-held capsule device |
US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
US20050272726A1 (en) * | 2004-04-22 | 2005-12-08 | Boehringer Ingelheim International Gmbh | Novel medicaments for the treatment of respiratory diseases |
ATE539754T1 (en) | 2004-04-22 | 2012-01-15 | Boehringer Ingelheim Int | DRUG COMBINATIONS CONTAINING BENZOXAZINES FOR THE TREATMENT OF RESPIRATORY DISEASES |
US7861712B2 (en) * | 2004-04-23 | 2011-01-04 | Manta Product Development | Sealed capsule including an integrated puncturing mechanism |
US7723306B2 (en) * | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
US7611709B2 (en) * | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
US7727962B2 (en) * | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
US20050256115A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta-agonists |
US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
WO2005110519A1 (en) * | 2004-05-17 | 2005-11-24 | Sun Pharmaceutical Industries Limited | Dry powder inhaler |
SE530006C2 (en) * | 2004-06-18 | 2008-02-05 | Mederio Ag | Inhaler using tub |
US7896195B2 (en) * | 2004-06-08 | 2011-03-01 | Ecolab Inc. | Tablet dispenser with isolated product hopper |
US20050283106A1 (en) * | 2004-06-17 | 2005-12-22 | Shane Smith | Reusable support device with therapeutic inserts |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
GB0418278D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Medicament dispenser |
BRPI0514263B8 (en) | 2004-08-20 | 2021-05-25 | Mannkind Corp | method for the synthesis of n-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine n-protected |
HUE026134T2 (en) | 2004-08-23 | 2016-05-30 | Mannkind Corp | Microparticles comprising diketopiperazine salts for drug delivery |
GB0418738D0 (en) * | 2004-08-23 | 2004-09-22 | 3M Innovative Properties Co | Medicinal aerosol formulation receptacle and production thereof |
US8165460B2 (en) * | 2004-10-26 | 2012-04-24 | The University Of North Carolina At Chapel Hill | Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods for using |
JP2006130143A (en) * | 2004-11-08 | 2006-05-25 | Hitachi Ltd | Inhalation administration device and medicine cartridge |
US20060120972A1 (en) * | 2004-11-09 | 2006-06-08 | Peter Engels | 9-(N-methyl-piperidyliden-4)-thioxanthene for treatment of pulmonary hypertension |
EP1812778A2 (en) * | 2004-11-12 | 2007-08-01 | Glaxo Group Limited | Sensor system with acoustic transducer |
US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
DK2522365T3 (en) | 2004-11-24 | 2017-02-06 | Meda Pharmaceuticals Inc | Compositions comprising azelastine and methods for its use |
GB0427858D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Manifold for use in medicament dispenser |
GB0427856D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Maniflod for use in medicament dispenser |
GB0427853D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Manifold for use in medicament dispenser |
BRPI0606712A2 (en) * | 2005-01-11 | 2010-03-16 | Glaxo Group Ltd | compound salt, pharmaceutical formulation, combination, use of a compound, and method for preparing a crystalline compound |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
WO2006084033A1 (en) * | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US20090029901A1 (en) * | 2005-02-10 | 2009-01-29 | Marian Wood-Kaczmar | Process for Crystallizing Lactose Particles for Use in Pharmaceutical Formulations |
GB0507711D0 (en) | 2005-04-15 | 2005-05-25 | Vectura Group Plc | Improved blister piercing |
US9585932B2 (en) | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
US8653028B2 (en) * | 2005-04-29 | 2014-02-18 | Rui Rong Yuan | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
SI1881980T1 (en) | 2005-05-02 | 2012-12-31 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
US8524735B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
ES2685315T3 (en) | 2005-05-18 | 2018-10-08 | Horizon Orphan Llc | Aerosol fluoroquinolones and their uses |
CA2611907A1 (en) * | 2005-06-17 | 2006-12-21 | Boehringer Ingelheim International Gmbh | Mrp iv inhibitors for the treatment of respiratory diseases |
DE102005030733A1 (en) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient |
US20070012316A1 (en) * | 2005-07-14 | 2007-01-18 | Joann Truza | Disposable compact rescue inhaler |
GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
US8763605B2 (en) * | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
CN101208316B (en) | 2005-08-15 | 2012-05-09 | 贝林格尔·英格海姆国际有限公司 | Method for producing betamimetics |
US20090192227A1 (en) * | 2005-08-24 | 2009-07-30 | Rabindra Tirouvanziam | N-Acetylcysteine Compositions and Methods for Treating Acute Exacerbations of Inflammatory Lung Disease |
WO2007024876A2 (en) * | 2005-08-24 | 2007-03-01 | The Board Of Trustees Of Leland Stanford Junior University | Methods for treating and monitoring inflammation and redox imbalance in cystic fibrosis |
US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
US8642543B2 (en) * | 2005-09-07 | 2014-02-04 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
US7481331B2 (en) * | 2005-09-09 | 2009-01-27 | Manrex Limited | Dispensing container for a blister pack of medications |
ES2640282T3 (en) | 2005-09-14 | 2017-11-02 | Mannkind Corporation | Drug formulation method based on increasing the affinity of crystalline microparticle surfaces for active agents |
US20070086957A1 (en) | 2005-10-10 | 2007-04-19 | Thierry Bouyssou | Combination of medicaments for the treatment of respiratory diseases |
US9107824B2 (en) | 2005-11-08 | 2015-08-18 | Insmed Incorporated | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
DE102005057685A1 (en) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhaler and storage for a dry drug formulation and methods and use thereof |
AR058290A1 (en) * | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | MEDICINAL DISPENSER |
AR058289A1 (en) * | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | COLLECTOR TO BE USED IN MEDICINAL DISPENSER |
DE102005059602A1 (en) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Micronization process |
CN104383546B (en) | 2006-02-22 | 2021-03-02 | 曼金德公司 | Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent |
AU2007224178B2 (en) * | 2006-03-03 | 2013-03-07 | Stc.Unm | Dry powder inhaler with aeroelastic dispersion mechanism |
US8127763B2 (en) * | 2006-03-03 | 2012-03-06 | Stc.Unm | Dry powder inhaler with aeroelastic dispersion mechanism |
DE102006016904A1 (en) * | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | inhaler |
EP1844808A1 (en) * | 2006-04-13 | 2007-10-17 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Medicament delivery device |
EP1844805A1 (en) * | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH & Co.KG | Inhaler |
EP2032664B1 (en) | 2006-05-19 | 2017-11-08 | Valspar Sourcing, Inc. | Coating system for cement composite articles |
WO2008008021A1 (en) * | 2006-07-14 | 2008-01-17 | Astrazeneca Ab | Inhalation system and delivery device for the administration of a drug in the form of dry powder. |
DE502007006951D1 (en) | 2006-08-07 | 2011-05-26 | Boehringer Ingelheim Pharma | MEDICINAL COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES |
PE20081358A1 (en) * | 2006-08-22 | 2008-10-31 | Boehringer Ingelheim Int | PHARMACOLOGICAL COMBINATIONS FOR THE TREATMENT OF DISEASES OF THE AIRWAY |
DE102006045788A1 (en) | 2006-09-26 | 2008-03-27 | Alfred Von Schuckmann | Dispenser for powdery masses |
US8573197B2 (en) | 2006-10-25 | 2013-11-05 | Novartis Ag | Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices |
GB0622827D0 (en) * | 2006-11-15 | 2006-12-27 | Glaxo Group Ltd | Sheet driver for use in a drug dispenser |
EP1925295A1 (en) | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stable powder formulation containing a new antichinolinergic agent |
EP2617431B1 (en) | 2007-01-10 | 2017-04-12 | Purdue Research Foundation | Polypeptide inhibitors of HSP27 kinase and uses therefor |
US20080237082A1 (en) * | 2007-03-29 | 2008-10-02 | R. P. Scherer Technologies, Inc. | Child resistant device for housing blister packs |
AT505246B8 (en) * | 2007-06-01 | 2009-06-15 | Croma Pharma Gmbh | CONTAINER FOR A MULTIPLE OF INDIVIDUAL CANS AND APPLICATOR FOR SUCH CONTAINERS |
US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
EP2898914B1 (en) | 2007-07-06 | 2018-06-20 | Manta Devices, LLC | Inhalation devices for storing and delivering medicament |
DK2185698T3 (en) * | 2007-08-07 | 2015-07-27 | Purdue Research Foundation | Kinase Inhibitors and Uses thereof |
EP2093219A1 (en) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Crystalline enantiomer free salt form of a betamimetic and its use as medicine |
PL2268160T3 (en) | 2008-03-20 | 2013-05-31 | Virun Inc | Emulsions including a peg-derivative of tocopherol |
CN102036661B (en) * | 2008-03-20 | 2016-12-28 | 维尔恩公司 | Vitamin derivative and application thereof |
IL279542B2 (en) | 2008-06-13 | 2023-10-01 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CA2728523C (en) | 2008-06-20 | 2020-03-10 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
CN102131407B (en) * | 2008-06-23 | 2015-01-07 | 维尔恩公司 | Compositions containing nono-polar compounds |
JP5339794B2 (en) * | 2008-07-04 | 2013-11-13 | キヤノン株式会社 | Inhaler |
TWI614024B (en) | 2008-08-11 | 2018-02-11 | 曼凱公司 | Use of ultrarapid acting insulin |
GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
ES2550309T3 (en) * | 2008-09-26 | 2015-11-06 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially predisposed perforators and related methods |
AU2009296538B8 (en) | 2008-09-26 | 2013-06-27 | Oriel Therapeutics, Inc. | Inhalers with airway disks having discrete airway channels and related disks and methods |
JP5470393B2 (en) | 2008-09-26 | 2014-04-16 | オリエル・セラピューティクス,インコーポレイテッド | Dry powder inhaler |
WO2010039201A2 (en) * | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US8646446B2 (en) * | 2008-10-01 | 2014-02-11 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
PL2346509T3 (en) * | 2008-10-07 | 2021-03-08 | Horizon Orphan Llc | Inhalation of levofloxacin for reducing lung inflammation |
KR20160150110A (en) | 2008-10-07 | 2016-12-28 | 랩터 파마슈티컬스 인코포레이티드 | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
BRPI0919759A2 (en) * | 2008-10-20 | 2017-03-21 | Moerae Matrix Inc | adhesion treatment and prevention polypeptides |
CA2742600A1 (en) * | 2008-11-04 | 2010-05-14 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta |
WO2010068692A1 (en) * | 2008-12-10 | 2010-06-17 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US8550074B2 (en) | 2009-01-15 | 2013-10-08 | Manta Devices, Llc | Delivery device and related methods |
GB0901520D0 (en) | 2009-01-30 | 2009-03-11 | Vectura Delivery Devices Ltd | Inhaler |
CN104523661A (en) | 2009-02-06 | 2015-04-22 | 南加利福尼亚大学 | Therapeutic compositions comprising monoterpenes |
EP2393492A1 (en) | 2009-02-09 | 2011-12-14 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
EP2405963B1 (en) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
PE20120647A1 (en) * | 2009-03-13 | 2012-05-31 | Nucitec Sa De Cv | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE |
CN102355918B (en) | 2009-03-18 | 2014-07-16 | 曼金德公司 | Inhaler adaptor for a laser diffraction apparatus and method for measuring particle size distribution |
MY157166A (en) | 2009-06-12 | 2016-05-13 | Mankind Corp | Diketopiperazine microparticles with defined specific surface areas |
WO2011005645A1 (en) | 2009-07-06 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Polymorph of [4,6-bis(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)pyrimidin-5-yl] |
MX2012000682A (en) | 2009-07-15 | 2012-02-28 | Theravance Inc | Crystalline freebase forms of a biphenyl compound. |
MX364173B (en) | 2009-07-24 | 2019-04-15 | Amazentis Sa Star | Compounds, compositions and methods for protecting brain health in neurodegenerative disorders. |
US9890195B2 (en) * | 2009-07-27 | 2018-02-13 | Purdue Research Foundation | MK2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
CA2773033C (en) | 2009-09-04 | 2016-10-11 | Mpex Pharmaceuticals, Inc. | Use of aerosolized levofloxacin for treating cystic fibrosis |
EP2477642A4 (en) * | 2009-09-17 | 2013-03-13 | Mutual Pharmaceutical Co | Method of treating asthma with antiviral agents |
US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
EP2498848A2 (en) | 2009-11-12 | 2012-09-19 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
EP2504318A2 (en) | 2009-11-24 | 2012-10-03 | Boehringer Ingelheim International GmbH | Crystalline salt forms of a pyrimidin-5-yl acetic acid derivative |
AU2010324980A1 (en) | 2009-11-24 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Process for preparing a polymorph of the choline salt of a pyrimidin-5-yl acetic acid derivative |
US10210216B2 (en) * | 2009-12-18 | 2019-02-19 | Sybase, Inc. | Dynamic attributes for mobile business objects |
US8507734B2 (en) | 2010-03-03 | 2013-08-13 | Neonc Technologies Inc. | Pharmaceutical compositions comprising monoterpenes |
WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
EP2563164B1 (en) | 2010-03-23 | 2016-06-29 | Virun, Inc. | Nanoemulsion including sucrose fatty acid ester |
USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
USD635246S1 (en) | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
BR112012033060A2 (en) | 2010-06-21 | 2018-02-27 | Mannkind Corp | Dry powder drug release system methods |
WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
EP3173080B1 (en) | 2010-08-27 | 2019-12-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising derivatives of perillyl alcohol |
US20160038600A1 (en) | 2012-08-03 | 2016-02-11 | Neonc Technologies Inc. | Pharmaceutical compositions comprising poh derivatives |
US8561609B2 (en) | 2010-12-07 | 2013-10-22 | Respira Therapeutics, Inc. | Dry powder inhaler |
BR112013015107B1 (en) | 2010-12-17 | 2022-03-22 | Neonc Technologies Inc. | Pharmaceutical composition, use of an isoperyl alcohol or an isoperyl alcohol carbamate and process for producing an isoperyl alcohol carbamate |
JP6021117B2 (en) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ,インク. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
CN105667994B (en) | 2011-04-01 | 2018-04-06 | 曼金德公司 | Blister package for pharmaceutical kit |
BR112013026313A8 (en) | 2011-04-12 | 2018-01-30 | Moerae Matrix Inc | compositions and methods for preventing or treating diseases, conditions or processes characterized by abnormal fibroblast proliferation and extracellular matrix deposition |
US9890200B2 (en) | 2011-04-12 | 2018-02-13 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
CA2981038C (en) | 2011-05-19 | 2018-09-25 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US8528569B1 (en) | 2011-06-28 | 2013-09-10 | Kyle D. Newton | Electronic cigarette with liquid reservoir |
US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
CN103945859A (en) | 2011-10-24 | 2014-07-23 | 曼金德公司 | Methods and compositions for treating pain |
EP2589381B1 (en) | 2011-11-04 | 2016-08-31 | Rabindra Tirouvanziam | Compositions for improving or preserving lung function in a patient with a pulmonary disorder |
WO2013114371A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dry powder formulations of dnase i |
EP2811847B1 (en) | 2012-02-10 | 2017-12-13 | Virun, Inc. | Beverage compositions containing non-polar compounds |
US10463815B2 (en) | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
WO2013134636A1 (en) | 2012-03-09 | 2013-09-12 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
WO2013176638A1 (en) | 2012-05-25 | 2013-11-28 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | An inhaler comprising a mouthpiece having an improved air channel |
MX354163B (en) | 2012-07-12 | 2018-02-15 | Mannkind Corp | Dry powder drug delivery systems and methods. |
DK2892524T3 (en) | 2012-09-04 | 2021-01-25 | Eleison Pharmaceuticals LLC | PREVENTION OF PULMONAL CANCER RECYCLING WITH LIPID-COMPLEXED CISPLATIN |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
GB201301192D0 (en) | 2013-01-23 | 2013-03-06 | Vectura Delivery Devices Ltd | A blister piercing element for a dry powder inhaler |
US10638792B2 (en) | 2013-03-15 | 2020-05-05 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
BR112015023168B1 (en) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | COMPOSITION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-CRYSTALLINE DICETOPIPERAZINE, METHOD OF PRODUCTION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-DICETOPIPERAZINE PARTICLES AND USE OF A CRYSTALLINE DICETOPIPERAZINE COMPOSITION |
DK177788B1 (en) | 2013-07-12 | 2014-07-07 | Liita Holdings Ltd | Inhaler |
KR102321339B1 (en) | 2013-07-18 | 2021-11-02 | 맨카인드 코포레이션 | Heat-stable dry powder pharmaceutical compositions and methods |
WO2015017728A1 (en) | 2013-07-31 | 2015-02-05 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
JP2016530930A (en) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | Ventilation device and method |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
MX2016003082A (en) | 2013-09-10 | 2016-09-13 | Univ Texas | Therapeutics targeting truncated adenomatous polyposis coli (apc) proteins. |
US10980273B2 (en) | 2013-11-12 | 2021-04-20 | VMR Products, LLC | Vaporizer, charger and methods of use |
US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
DE202014011221U1 (en) | 2013-12-23 | 2018-09-13 | Juul Labs Uk Holdco Limited | Systems for an evaporation device |
USD769438S1 (en) * | 2014-01-08 | 2016-10-18 | Glaxo Group Limited | Inhaler device |
NZ722927A (en) | 2014-01-10 | 2022-07-29 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
TWI751467B (en) | 2014-02-06 | 2022-01-01 | 美商尤爾實驗室有限公司 | A device for generating an inhalable aerosol and a separable cartridge for use therewith |
US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10336788B2 (en) | 2014-04-17 | 2019-07-02 | Moerae Matrix, Inc. | Inhibition of cardiac fibrosis in myocardial infarction |
WO2015164142A1 (en) * | 2014-04-24 | 2015-10-29 | Questa Corporation | Multi-size pill splitter and methods |
EP3137140B1 (en) * | 2014-05-02 | 2019-07-10 | Manta Devices, LLC | Delivery device |
CA2948441A1 (en) | 2014-05-12 | 2015-11-19 | Glaxosmithkline Intellectual Property (No. 2) Limited | Pharmaceutical compositions for treating infectious diseases |
US10940279B2 (en) * | 2014-07-01 | 2021-03-09 | Jennifer K. Keener | Aromatherapy device |
US10082496B2 (en) | 2014-09-10 | 2018-09-25 | Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US20170304459A1 (en) | 2014-10-10 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
CN107106641B (en) | 2014-10-31 | 2021-12-21 | 葛兰素史密斯克莱知识产权发展有限公司 | Powder formulation |
BR112017010238A2 (en) | 2014-11-17 | 2018-02-06 | Moerae Matrix, Inc. | compositions and methods for preventing or treating diseases, conditions or processes characterized by fibroblast proliferation and aberrant extracellular matrix deposition |
EP3229831B1 (en) | 2014-12-10 | 2020-03-11 | Hyperstem SA | Methods and compositions for reducing growth, migration and invasiveness of brain cancer stem cells and improving survival of patients with brain tumors |
JP2018502860A (en) | 2015-01-08 | 2018-02-01 | モイライ マトリックス インコーポレイテッド | MK2 inhibitory peptide preparation |
MX2017009112A (en) | 2015-01-14 | 2018-06-15 | Respira Therapeutics Inc | Powder dispersion methods and devices. |
JP6674957B2 (en) | 2015-02-12 | 2020-04-01 | ネオンク テクノロジーズ インク. | Pharmaceutical composition containing perillyl alcohol derivative |
EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
MX2017011633A (en) | 2015-03-12 | 2017-11-02 | Moerae Matrix Inc | Use of mk2 inhibitor peptide-containing compositions for treating non-small cell lung cancer with same. |
US10179215B2 (en) | 2015-03-19 | 2019-01-15 | Altria Client Services Llc | Vaporizer for vaporizing a constituent of a plant material |
AU2016201131B2 (en) * | 2015-03-30 | 2020-04-02 | Manrex Limited | Dispensing container for blister pack of medication |
EP3307069B1 (en) | 2015-06-10 | 2021-08-04 | Hackensack University Medical Center | Use of telmisartan to prevent and treat graft versus host disease and other alloimmune and autoimmune diseases |
CN107949279A (en) | 2015-07-06 | 2018-04-20 | 得克萨斯系统大学评议会 | It can be used as the benzamide or benzamine compound of the anticancer for treating human cancer |
WO2017011215A1 (en) | 2015-07-15 | 2017-01-19 | The Board Of Regents Of The University Of Texas System | Targeting emopamil binding protein (ebp) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis |
EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
CN104984448B (en) * | 2015-07-30 | 2018-05-01 | 中山市美捷时包装制品有限公司 | A kind of Diskus |
CN105013054B (en) * | 2015-07-30 | 2018-11-09 | 中山市美捷时包装制品有限公司 | A kind of more capsule dry-powder inhaling devices |
JP2018535984A (en) | 2015-11-18 | 2018-12-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | Ribavirin pharmaceutical composition |
US11833118B2 (en) | 2016-01-20 | 2023-12-05 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
EP3405175A4 (en) | 2016-01-20 | 2019-09-25 | Flurry Powders, LLC | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
USD861975S1 (en) | 2016-02-08 | 2019-10-01 | Juul Labs, Inc. | Vaporizer device with cartridges |
WO2017139595A1 (en) | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Fillable vaporizer cartridge and method of filling |
WO2017144386A1 (en) * | 2016-02-24 | 2017-08-31 | Boehringer Ingelheim International Gmbh | Inhaler |
UA126061C2 (en) | 2016-02-25 | 2022-08-10 | Джуул Лебз, Інк. | Vaporization device control systems and methods |
WO2018102412A1 (en) | 2016-11-30 | 2018-06-07 | Neonc Technologies, Inc. | A perillyl alcohol-3 bromopyruvate conjugate and methods of treating cancer |
US10426698B2 (en) * | 2016-12-08 | 2019-10-01 | Breeden Brothers, LLC | Pill container with cap |
WO2018174938A1 (en) | 2017-03-23 | 2018-09-27 | Virun, Inc. | Stable dry powders and emulsions containing probiotics and mucoadhesive protein |
WO2019157195A1 (en) | 2018-02-08 | 2019-08-15 | Neonc Technologies, Inc | Methods of permeabilizing the blood brain barrier |
CN112969457A (en) | 2018-10-17 | 2021-06-15 | 共晶制药公司 | Combinations of inhibitors of influenza virus replication |
DE102020100550A1 (en) * | 2019-01-14 | 2020-07-16 | Alfred Von Schuckmann | Device for inhaling powdery substances, substance container for such a device and method for filling such a device |
DE102019134285A1 (en) | 2019-01-15 | 2020-07-16 | Nuuvera Deutschland GmbH | Device and method for extracting and aspirating active substances, in particular from the cannabis plant |
KR20220006039A (en) | 2019-03-14 | 2022-01-14 | 옴 파르마 에스아 | Methods of treating and/or preventing diseases associated with asthma, asthma exacerbations, allergic asthma and/or microbiota associated with respiratory disorders |
PE20212261A1 (en) | 2019-03-14 | 2021-11-29 | Om Pharma Sa | STABLE BACTERIAL EXTRACTS AS DRUGS |
USD943161S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
USD943158S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer cartridge |
USD943160S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
USD943159S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Component for a vaporizer cartridge |
US20230151034A1 (en) | 2020-03-17 | 2023-05-18 | Cocrystal Pharma, Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
IL310394A (en) | 2021-08-03 | 2024-03-01 | Cocrystal Pharma Inc | Inhibitors for coronaviruses |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
WO2023205389A1 (en) | 2022-04-22 | 2023-10-26 | Quench Medical Inc. | Dry powder inhalation delivery of pharmaceuticals |
WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB190707525A (en) * | 1906-04-07 | 1907-11-28 | Eugene Joseph Decoll | Impovements relating to Appliances for Administering Anestetics |
GB190706553A (en) * | 1907-03-19 | 1907-11-28 | Hume Purdie | Surgical Apparatus for the Administration of Anaesthetics |
US1383270A (en) * | 1918-10-02 | 1921-06-28 | Henning Albert | Means for cooling internal-combustion engines and other machinery |
US2386877A (en) * | 1943-07-27 | 1945-10-16 | Jr William E Neilson | Box opener and dispenser |
US3949751A (en) * | 1970-03-03 | 1976-04-13 | Fisons Limited | Method and device for dispensing medicament to the body |
US3888253A (en) * | 1972-08-04 | 1975-06-10 | Beecham Group Ltd | Device for administration of medicines |
GB1392945A (en) * | 1972-08-23 | 1975-05-07 | Fisons Ltd | Inhalation device |
GB1387954A (en) * | 1973-05-08 | 1975-03-19 | Miles Lab | Insufflator |
US4014336A (en) * | 1975-01-13 | 1977-03-29 | Syntex Puerto Rico, Inc. | Inhalation device |
GB1562732A (en) * | 1976-02-10 | 1980-03-12 | Allen & Hanburys Ltd | Device for dispensing medicaments |
DE2834135C3 (en) * | 1978-08-03 | 1981-11-26 | SIEMENS AG AAAAA, 1000 Berlin und 8000 München | Method for manufacturing a traveling wave tube |
DE2835135C3 (en) * | 1978-08-10 | 1982-03-04 | Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart | Active substance storage for an inhalation device |
IT1116047B (en) * | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA |
WO1981001243A1 (en) * | 1979-10-30 | 1981-05-14 | Riker Laboratories Inc | Breath actuated devices for administering powdered medicaments |
GB2061735B (en) * | 1979-10-30 | 1983-11-30 | Riker Laboratories Inc | Breath actuated device for administration of powdered medicaments by inhalation |
DE3167567D1 (en) * | 1980-06-06 | 1985-01-17 | Fisons Plc | Inhalation device for powdered medicaments |
ES8206980A1 (en) * | 1980-10-30 | 1982-09-01 | Riker Laboratories Inc | Powder inhalation device. |
US4384649A (en) * | 1980-12-11 | 1983-05-24 | E. R. Squibb & Sons, Inc. | Dispensing package |
US4444610A (en) * | 1981-03-27 | 1984-04-24 | S.A.R.L. Eroa Holding | Method and apparatus for providing piercing tabs on the lids of containers |
ZA837318B (en) * | 1982-10-08 | 1985-06-26 | Glaxo Group Ltd | Device for administering medicaments to patients |
LU85034A1 (en) * | 1982-10-08 | 1985-06-19 | Glaxo Group Ltd | DEVICES FOR DELIVERY OF MEDICINES TO PATIENTS |
GB8314308D0 (en) * | 1983-05-24 | 1983-06-29 | Matburn Holdings Ltd | Medical administration devices |
DE3345722A1 (en) * | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | INHALATOR |
GB2178965B (en) * | 1985-07-30 | 1988-08-03 | Glaxo Group Ltd | Devices for administering medicaments to patients |
US4690279A (en) * | 1986-03-13 | 1987-09-01 | Charles Hochberg | Birth control pill dispenser in the form of a hair brush |
-
1986
- 1986-07-29 GB GB08618466A patent/GB2178965B/en not_active Expired
- 1986-07-29 BR BR8603576A patent/BR8603576A/en not_active IP Right Cessation
- 1986-07-29 CA CA000514908A patent/CA1272917A/en not_active Expired - Lifetime
- 1986-07-29 PT PT83094A patent/PT83094B/en not_active IP Right Cessation
- 1986-07-29 FR FR8610955A patent/FR2585563B1/en not_active Expired - Lifetime
- 1986-07-29 EP EP86305807A patent/EP0211595B1/en not_active Expired - Lifetime
- 1986-07-29 GR GR861995A patent/GR861995B/en unknown
- 1986-07-29 FI FI863094A patent/FI88112C/en not_active IP Right Cessation
- 1986-07-29 AU AU60655/86A patent/AU591152B2/en not_active Expired
- 1986-07-29 ES ES8600683A patent/ES2000781A6/en not_active Expired
- 1986-07-29 IT IT48322/86A patent/IT1195984B/en active
- 1986-07-29 IL IL79550A patent/IL79550A/en not_active IP Right Cessation
- 1986-07-29 BE BE0/216987A patent/BE905189A/en not_active IP Right Cessation
- 1986-07-29 SE SE8603252A patent/SE8603252L/en not_active Application Discontinuation
- 1986-07-29 DK DK360986A patent/DK163640C/en not_active IP Right Cessation
- 1986-07-29 IE IE202286A patent/IE59026B1/en not_active IP Right Cessation
- 1986-07-29 PH PH34078A patent/PH26882A/en unknown
- 1986-07-29 NO NO863062A patent/NO166268C/en not_active IP Right Cessation
- 1986-07-29 CH CH3025/86A patent/CH672600A5/de not_active IP Right Cessation
- 1986-07-29 NL NL8601949A patent/NL8601949A/en not_active Application Discontinuation
- 1986-07-29 DE DE8686305807T patent/DE3682457D1/en not_active Expired - Lifetime
- 1986-07-29 NZ NZ217006A patent/NZ217006A/en unknown
- 1986-07-29 AT AT0204086A patent/AT396872B/en not_active IP Right Cessation
- 1986-07-29 US US06/891,536 patent/US4811731A/en not_active Expired - Lifetime
- 1986-07-30 DE DE19863625685 patent/DE3625685A1/en active Granted
- 1986-07-30 LU LU86534A patent/LU86534A1/en unknown
- 1986-07-30 KR KR1019860006254A patent/KR940002247B1/en not_active IP Right Cessation
- 1986-07-30 JP JP61177917A patent/JPS6241668A/en active Granted
- 1986-07-30 HU HU863243A patent/HU199306B/en not_active IP Right Cessation
- 1986-07-30 MX MX003326A patent/MX171389B/en unknown
- 1986-07-30 PL PL1986260858A patent/PL149733B1/en unknown
-
1988
- 1988-12-27 US US07/290,628 patent/US5035237A/en not_active Expired - Lifetime
-
1989
- 1989-02-14 SG SG87/89A patent/SG8789G/en unknown
- 1989-02-24 KE KE3865A patent/KE3865A/en unknown
- 1989-08-24 HK HK675/89A patent/HK67589A/en not_active IP Right Cessation
- 1989-08-29 DO DO1989004707A patent/DOP1989004707A/en unknown
- 1989-12-08 CY CY1481A patent/CY1481A/en unknown
Cited By (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5035237A (en) * | 1985-07-30 | 1991-07-30 | Newell Robert E | Devices for administering medicaments to patients |
GB2246299A (en) * | 1990-06-08 | 1992-01-29 | Glaxo Group Ltd | Medicament-containing article and device therefor. |
US5320095A (en) * | 1990-12-10 | 1994-06-14 | Pharmachemie B.V. | Device for use with the inhalation of powdered materials contained in rod-shaped capsules |
US5715810A (en) * | 1991-07-25 | 1998-02-10 | Sepracor Inc. | Inhalation devices |
US5337740A (en) * | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
GB2264237A (en) * | 1992-02-05 | 1993-08-25 | Robert Edward Newell | An inhaler |
US5778873A (en) * | 1992-02-21 | 1998-07-14 | Innovata Biomed Limited | Metering device for use in transferring a desired volumetric dose of a flowable substance from a storage container |
US5673686A (en) * | 1994-02-02 | 1997-10-07 | Plurichemie Anstalt | Medicament inhaler and method |
EP0938907A1 (en) | 1996-01-03 | 1999-09-01 | Glaxo Group Limited | Inhalation device |
US5794613A (en) * | 1997-01-09 | 1998-08-18 | Sepracor, Inc. | Multiple-dose dispenser for dry powder inhalers |
US8205614B2 (en) | 1999-09-04 | 2012-06-26 | Innovata Biomed Limited | Delivery device |
US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
WO2002012266A1 (en) | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
EP2348032A2 (en) | 2000-08-05 | 2011-07-27 | Glaxo Group Limited | 6.Alpha.,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothiotic acid s-fluoromethyl ester as an anti-inflammatory agent |
EP2067784A2 (en) | 2000-08-05 | 2009-06-10 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivates as anti-flammatory agents |
EP1775305A2 (en) | 2000-08-05 | 2007-04-18 | Glaxo Group Limited | 6.Alpha.,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothiotic acid s-fluoromethyl ester as an anti-inflammatory agent |
US7135600B2 (en) | 2001-02-14 | 2006-11-14 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7442836B2 (en) | 2001-02-14 | 2008-10-28 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7442719B2 (en) | 2001-02-14 | 2008-10-28 | Glaxo Group Limited | Methods using phenethanolamine derivatives for treatment of respiratory diseases |
US7442837B2 (en) | 2001-02-14 | 2008-10-28 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7045658B2 (en) | 2001-03-22 | 2006-05-16 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
EP2039700A2 (en) | 2001-04-30 | 2009-03-25 | Glaxo Group Limited | Novel anti-inflammatory androstane derivatives |
US7361787B2 (en) | 2001-09-14 | 2008-04-22 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7776895B2 (en) | 2001-09-14 | 2010-08-17 | Glaxo Group Limited | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases |
US7439393B2 (en) | 2001-09-14 | 2008-10-21 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
USRE44874E1 (en) | 2001-09-14 | 2014-04-29 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US7982067B2 (en) | 2001-09-14 | 2011-07-19 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
US8198483B2 (en) | 2001-09-14 | 2012-06-12 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
EP2042168A1 (en) | 2001-09-14 | 2009-04-01 | Glaxo Group Limited | Inhalation device comprising phenethanolamine derivatives for treatment of respiratory diseases |
US8337816B2 (en) | 2001-09-17 | 2012-12-25 | Glaxo Group Limited | Dry powder medicament formulations |
US8800550B2 (en) | 2001-11-23 | 2014-08-12 | Innovata Biomed Limited | Medicament delivery assembly |
EP2363121A1 (en) | 2002-02-04 | 2011-09-07 | Glaxo Group Limited | Pharmaceutical formulation for administration by inhalation comprising an androstane derivative and a beta-2-adrenoreceptor agonist for the treatment of inflammatory and allergic conditions |
US7271197B2 (en) | 2002-04-25 | 2007-09-18 | Glaxo Group Limited | Phenethanolamine derivatives |
US7402598B2 (en) | 2002-07-25 | 2008-07-22 | Glaxo Group Limited | Arylethanolamine β2-adrenoreceptor agonist compounds |
US7442839B2 (en) | 2002-10-28 | 2008-10-28 | Glaxo Group Limited | Phenethanolamine derivative for the treatment of respiratory diseases |
US7538127B2 (en) | 2003-02-14 | 2009-05-26 | Glaxo Group Limited | Medicinal compounds |
US7495010B2 (en) | 2003-07-17 | 2009-02-24 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7579361B2 (en) | 2003-10-14 | 2009-08-25 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7576096B2 (en) | 2003-10-14 | 2009-08-18 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7507747B2 (en) | 2003-10-17 | 2009-03-24 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
WO2005046586A2 (en) | 2003-11-04 | 2005-05-26 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
US7563803B2 (en) | 2003-11-04 | 2009-07-21 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
US7439255B2 (en) | 2003-11-04 | 2008-10-21 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7906531B2 (en) | 2003-11-04 | 2011-03-15 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
US7294650B2 (en) | 2003-12-17 | 2007-11-13 | Glaxo Group Limited | Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders |
US7384946B2 (en) | 2004-03-17 | 2008-06-10 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
US7846973B2 (en) | 2004-04-02 | 2010-12-07 | Theravance, Inc. | Chemical process and new crystalline form |
US8851069B2 (en) | 2004-04-21 | 2014-10-07 | Innovata Biomed Limited | Inhaler |
US8511302B2 (en) | 2004-04-24 | 2013-08-20 | Innovata Biomed Limited | Dose counter mechanisms for medicament delivery devices |
US8183257B2 (en) | 2004-04-27 | 2012-05-22 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US9045469B2 (en) | 2004-04-27 | 2015-06-02 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7488827B2 (en) | 2004-04-27 | 2009-02-10 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US8853404B2 (en) | 2004-04-27 | 2014-10-07 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US9144571B2 (en) | 2004-04-27 | 2015-09-29 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
EP2570128A1 (en) | 2004-04-27 | 2013-03-20 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7498440B2 (en) | 2004-04-27 | 2009-03-03 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US8575347B2 (en) | 2004-04-27 | 2013-11-05 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
WO2005104745A2 (en) | 2004-04-27 | 2005-11-10 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US8309572B2 (en) | 2004-04-27 | 2012-11-13 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US7598267B2 (en) | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
US9365905B2 (en) | 2005-02-10 | 2016-06-14 | Dmv-Fonterra Excipients Technology Gmbh | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
EP3199164A1 (en) | 2005-02-10 | 2017-08-02 | Glaxo Group Limited | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
EP2447266A1 (en) | 2005-03-25 | 2012-05-02 | Glaxo Group Limited | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator |
EP2436686A1 (en) | 2005-03-25 | 2012-04-04 | Glaxo Group Limited | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator |
WO2006104889A2 (en) | 2005-03-25 | 2006-10-05 | Glaxo Group Limited | Novel compounds |
US7767691B2 (en) | 2005-08-18 | 2010-08-03 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system |
US8109267B2 (en) | 2006-05-16 | 2012-02-07 | Hovione International Ltd. | Simple inhaler |
WO2008118724A1 (en) | 2007-03-23 | 2008-10-02 | Smithkline Beecham Corporation | Indole carboxamides as ikk2 inhibitors |
US7956065B2 (en) | 2008-09-08 | 2011-06-07 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compounds |
US11116721B2 (en) | 2009-02-26 | 2021-09-14 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl) phenol |
WO2010147947A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF |
US11090294B2 (en) | 2009-12-01 | 2021-08-17 | Glaxo Group Limited | Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist |
WO2012028663A1 (en) | 2010-08-31 | 2012-03-08 | Glaxo Group Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
WO2012028662A1 (en) | 2010-08-31 | 2012-03-08 | Glaxo Group Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
EP2954888A1 (en) | 2010-08-31 | 2015-12-16 | GlaxoSmithKline Intellectual Property Development Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
US9297813B2 (en) | 2010-11-11 | 2016-03-29 | Agency For Science, Technology And Research | Targeting metabolic enzymes in human cancer |
WO2013045431A1 (en) | 2011-09-27 | 2013-04-04 | Glaxo Group Limited | Sulfonamide compounds and their use in the modulation retinoid - related orphan receptor |
WO2013160419A1 (en) | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
WO2013160418A1 (en) | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
WO2014085474A1 (en) | 2012-11-28 | 2014-06-05 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
WO2016142426A1 (en) | 2015-03-11 | 2016-09-15 | Glaxosmithkline Intellectual Property Development Limited | Tslp binding proteins |
WO2016203401A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
WO2016203400A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
EP3766878A1 (en) | 2015-06-15 | 2021-01-20 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
EP3782996A1 (en) | 2015-06-15 | 2021-02-24 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
WO2017029602A2 (en) | 2015-08-16 | 2017-02-23 | Glaxosmithkline Intellectual Property Development Limited | Compounds for use in antibacterial applications |
WO2017060854A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
WO2017060855A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
WO2018055527A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018055524A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018055526A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018104766A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators |
WO2018109641A1 (en) | 2016-12-12 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | 3-carboxylic acid pyrroles as nrf2 regulators |
WO2018109642A1 (en) | 2016-12-12 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
WO2018109647A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl amides as nrf2 regulators |
WO2018109643A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as nrf2 acti |
WO2018109648A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | 3-oxo-1,4-diazepinyle compounds as nrf2 activators |
WO2018109649A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Ether linked triazoles as nrf2 regulators |
WO2018109646A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 compounds |
US11014941B2 (en) | 2017-04-24 | 2021-05-25 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
WO2019116230A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
WO2019116231A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
WO2019115640A1 (en) | 2017-12-15 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | 6-(morpholin-4-yl)-pyridin-2-yl-1h-pyrrolo[3,2-b]pyridine derivatives as m-tor inhibitors |
WO2019141694A1 (en) | 2018-01-17 | 2019-07-25 | Glaxosmithkline Intellectual Property Development Limited | Pi4kiiibeta inhibitors |
WO2019224667A1 (en) | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Indanes as nrf2 activators |
WO2020023813A1 (en) | 2018-07-27 | 2020-01-30 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication |
WO2020055858A1 (en) | 2018-09-10 | 2020-03-19 | Cocrystal Pharma, Inc. | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication |
WO2020102270A1 (en) | 2018-11-13 | 2020-05-22 | Cocrystal Pharma, Inc. | Formulations of influenza therapeutics |
WO2020112716A1 (en) | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
WO2020249652A1 (en) | 2019-06-13 | 2020-12-17 | Glaxosmithkline Intellectual Property Development Limited | Pyridyl or pyrimidyl mtor kinase inhibitors |
WO2021206876A1 (en) | 2020-04-10 | 2021-10-14 | Cocrystal Pharma, Inc. | Inhibitors of norovirus and coronavirus replication |
WO2021216547A1 (en) | 2020-04-20 | 2021-10-28 | Sorrento Therapeutics, Inc. | Pulmonary administration of ace2 polypeptides |
WO2022175425A1 (en) | 2021-02-22 | 2022-08-25 | Glaxosmithkline Intellectual Property Development Limited | Inhaled mtor kinase inhibitors for use in the treatment or the prevention of a respiratory rna virus infection |
WO2022179967A1 (en) | 2021-02-23 | 2022-09-01 | Glaxosmithkline Intellectual Property (No.2) Limited | Vadadustat for treating covid-19 in a hospitalized subject |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0211595B1 (en) | Devices for administering medicaments to patients | |
EP2398537B1 (en) | Inhaler | |
DK172541B1 (en) | Apparatus for administering medications to patients and a drug package for use in the apparatus | |
EP2377566B1 (en) | Inhaler | |
EP0129985A1 (en) | Inhalation device | |
GB2169265A (en) | Pack for medicament | |
GB2340758A (en) | Drug dispensing system | |
CZ288921B6 (en) | Blister disk for inhaler | |
DK173079B1 (en) | Hand-held inhaler for powder or liq. medical inhalants - which are in dose sized blisters of circular disc blister pack | |
IE56060B1 (en) | Medicament-containing pack |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE20 | Patent expired after termination of 20 years |
Effective date: 20060728 |