GB2153356B - Nucleoside phosphoramidites and oligonucleotides produced therefrom - Google Patents

Nucleoside phosphoramidites and oligonucleotides produced therefrom

Info

Publication number
GB2153356B
GB2153356B GB08432205A GB8432205A GB2153356B GB 2153356 B GB2153356 B GB 2153356B GB 08432205 A GB08432205 A GB 08432205A GB 8432205 A GB8432205 A GB 8432205A GB 2153356 B GB2153356 B GB 2153356B
Authority
GB
United Kingdom
Prior art keywords
produced therefrom
nucleoside phosphoramidites
oligonucleotides produced
oligonucleotides
phosphoramidites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08432205A
Other languages
English (en)
Other versions
GB8432205D0 (en
GB2153356A (en
Inventor
Lloyd M Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of GB8432205D0 publication Critical patent/GB8432205D0/en
Priority to GB8517170A priority Critical patent/GB2162571B/en
Publication of GB2153356A publication Critical patent/GB2153356A/en
Application granted granted Critical
Publication of GB2153356B publication Critical patent/GB2153356B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
GB08432205A 1983-11-15 1984-12-20 Nucleoside phosphoramidites and oligonucleotides produced therefrom Expired GB2153356B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8517170A GB2162571B (en) 1983-11-15 1985-07-05 Glazing gasket

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56501083A 1983-12-20 1983-12-20

Publications (3)

Publication Number Publication Date
GB8432205D0 GB8432205D0 (en) 1985-01-30
GB2153356A GB2153356A (en) 1985-08-21
GB2153356B true GB2153356B (en) 1987-07-22

Family

ID=24256835

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08432205A Expired GB2153356B (en) 1983-11-15 1984-12-20 Nucleoside phosphoramidites and oligonucleotides produced therefrom

Country Status (6)

Country Link
JP (3) JPS60197698A (de)
CA (1) CA1244786A (de)
DE (1) DE3446635C2 (de)
FR (1) FR2556726B1 (de)
GB (1) GB2153356B (de)
SE (1) SE466208B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5118800A (en) * 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
USRE43096E1 (en) 1984-01-16 2012-01-10 California Institute Of Technology Tagged extendable primers and extension products
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
GB8509880D0 (en) * 1985-04-17 1985-05-22 Ici Plc Testing device
US4762779A (en) * 1985-06-13 1988-08-09 Amgen Inc. Compositions and methods for functionalizing nucleic acids
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
DE3642939A1 (de) * 1986-06-03 1987-12-10 Europ Lab Molekularbiolog Verfahren zur dna-markierung
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5242796A (en) * 1986-07-02 1993-09-07 E. I. Du Pont De Nemours And Company Method, system and reagents for DNA sequencing
US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4833332A (en) * 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US4965349A (en) * 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5262536A (en) * 1988-09-15 1993-11-16 E. I. Du Pont De Nemours And Company Reagents for the preparation of 5'-tagged oligonucleotides
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
WO1992010505A1 (en) * 1990-12-11 1992-06-25 Abbott Laboratories Methods for labelling oligonucleotides
US5643722A (en) * 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
SE522077C2 (sv) 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
DE19815864A1 (de) 1998-04-08 1999-10-14 Europ Lab Molekularbiolog 5'-modifizierte Nukleotide und ihre Anwendung in der Molekularbiologie und Medizin
AU2998800A (en) 1999-03-24 2000-10-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The N-acylphosphoramidites and their use in oligonucleotide synthesis
US7355037B2 (en) 2001-12-03 2008-04-08 The United States Of America As Represented By The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
US9809824B2 (en) 2004-12-13 2017-11-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3284440A (en) * 1964-06-12 1966-11-08 Merck & Co Inc Phosphate esters of cytosine arabinoide and process for preparing same
US3847898A (en) * 1969-05-27 1974-11-12 Upjohn Co N4-trihaloethoxy carbonyl arabino-furanosyl cytosine 5'-esters
IL57570A (en) * 1978-06-22 1982-07-30 Miles Lab Method and reagent for specific binding assay with a prosthetic group as a label component
IL57571A (en) * 1978-06-22 1983-03-31 Miles Lab Flavin adenine dinucleotide-labeled conjugates and their use in a homogeneous immunoassay method for determining haptens
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn

Also Published As

Publication number Publication date
CA1244786A (en) 1988-11-15
SE8406484L (sv) 1985-06-21
DE3446635A1 (de) 1985-06-27
SE8406484D0 (sv) 1984-12-19
JPH0157119B2 (de) 1989-12-04
DE3446635C2 (de) 1997-08-07
FR2556726B1 (fr) 1987-02-20
JPS60197698A (ja) 1985-10-07
GB8432205D0 (en) 1985-01-30
GB2153356A (en) 1985-08-21
JPH0678353B2 (ja) 1994-10-05
JPH0460600B2 (de) 1992-09-28
FR2556726A1 (fr) 1985-06-21
JPH06145192A (ja) 1994-05-24
JPH01250393A (ja) 1989-10-05
SE466208B (sv) 1992-01-13

Similar Documents

Publication Publication Date Title
GB2153356B (en) Nucleoside phosphoramidites and oligonucleotides produced therefrom
GB2136425B (en) Nucleosides
DE3463384D1 (en) Oligonucleotide derivatives and production thereof
GB8517235D0 (en) Console
GB8500850D0 (en) Antiviral agents
EP0378615A4 (en) Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
PT79613B (en) N6-(1 and 2- benzocycloalkyl)adenosines
PT79008B (en) N6-substituted adenosines
GB2168337B (en) Ceramic foam
ZA843152B (en) Antiviral agents
GB8527211D0 (en) Ceramic foam
DE3366262D1 (en) Nucleoside 5'-alkyl- or alkenylphosphate
GB2209063B (en) Partitions
EP0179667A3 (en) N6-substituted adenosines
GB8528823D0 (en) Forming perforations in bar-shaped articles
DE3569738D1 (en) N6-acenaphthyl adenosines and analogs thereof
DE3468322D1 (en) Antiviral agent
ZA857998B (en) N6-substituted adenosines
ZA845311B (en) N6-substituted adenosines
GB8315807D0 (en) Nucleosides
GB8510648D0 (en) Partitions
ZA844744B (en) Antiviral agents
ZA893840B (en) Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
KR840002160Y1 (en) Melody comb
GB2154400B (en) Distributed arbitration circuitry

Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20041219