GB2092136B - Production of n-substituted amide compounds - Google Patents

Production of n-substituted amide compounds

Info

Publication number
GB2092136B
GB2092136B GB8200372A GB8200372A GB2092136B GB 2092136 B GB2092136 B GB 2092136B GB 8200372 A GB8200372 A GB 8200372A GB 8200372 A GB8200372 A GB 8200372A GB 2092136 B GB2092136 B GB 2092136B
Authority
GB
United Kingdom
Prior art keywords
production
amide compounds
substituted amide
substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8200372A
Other languages
English (en)
Other versions
GB2092136A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP461081A external-priority patent/JPS57118542A/ja
Priority claimed from JP19844181A external-priority patent/JPS58103348A/ja
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Publication of GB2092136A publication Critical patent/GB2092136A/en
Application granted granted Critical
Publication of GB2092136B publication Critical patent/GB2092136B/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1854Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
    • C07C273/1863Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/14Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8200372A 1981-01-17 1982-01-07 Production of n-substituted amide compounds Expired GB2092136B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP461081A JPS57118542A (en) 1981-01-17 1981-01-17 Preparation of n-substituted amide compound
JP19844181A JPS58103348A (ja) 1981-12-11 1981-12-11 N−アルキル置換不飽和アミド化合物の製造方法

Publications (2)

Publication Number Publication Date
GB2092136A GB2092136A (en) 1982-08-11
GB2092136B true GB2092136B (en) 1985-06-05

Family

ID=26338415

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8200372A Expired GB2092136B (en) 1981-01-17 1982-01-07 Production of n-substituted amide compounds

Country Status (6)

Country Link
US (1) US4835312A (cg-RX-API-DMAC10.html)
CH (1) CH648288A5 (cg-RX-API-DMAC10.html)
DE (3) DE3249628C2 (cg-RX-API-DMAC10.html)
FR (1) FR2498182B1 (cg-RX-API-DMAC10.html)
GB (1) GB2092136B (cg-RX-API-DMAC10.html)
NL (1) NL187805C (cg-RX-API-DMAC10.html)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118846A (en) * 1990-04-27 1992-06-02 The Standard Oil Company Synthesis of N-disubstituted amides by reaction of amides with certain organic hydroxyl compounds
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) * 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US6331318B1 (en) * 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6916489B2 (en) * 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
DE4302860A1 (de) * 1993-01-22 1994-08-04 Chemie Linz Deutschland N-Cyclische und N,N'dicyclische Harnstoffe
AT400566B (de) * 1993-01-22 1996-01-25 Chemie Linz Gmbh Verwendung und verfahren zur herstellung von n-cyclischen und n,n'-dicyclischen harnstoffen
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
ATE204467T1 (de) * 1993-04-22 2001-09-15 Emisphere Tech Inc Orale darreichungsform
US6610329B2 (en) 1993-04-22 2003-08-26 Emisphere Technologies Inc. Compositions for the delivery of antigens
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
DE4404222A1 (de) * 1994-02-10 1995-08-17 Bayer Ag Verwendung von Dicarbonsäure-bis-dimethylamiden als Kristallisationsinhibitoren
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) * 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
GB9514031D0 (en) * 1995-07-10 1995-09-06 Zeneca Ltd Chemical process
DE19681560T1 (de) * 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
AU3828597A (en) 1996-06-14 1998-01-07 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US5879681A (en) * 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5990166A (en) * 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
TR200100366T2 (tr) * 1998-08-07 2001-11-21 Emisphere Technologies, Inc. Aktif madde dağıtmaya mahsus bileşikler ve bileşimler.
US6991798B1 (en) 1998-08-07 2006-01-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6967250B1 (en) * 1998-08-31 2005-11-22 Amersham Biosciences Corp Energy transfer dyes
CA2361716C (en) 1999-02-05 2009-04-28 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
CA2369591C (en) * 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US7129274B1 (en) * 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
JP4850379B2 (ja) 1999-12-16 2012-01-11 エミスフェアー・テクノロジーズ・インク 活性剤を輸送するための化合物及び組成物
AU2001236457A1 (en) 2000-01-13 2001-07-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6369249B1 (en) * 2000-02-02 2002-04-09 Council Of Scientific & Industrial Research Process for the preparation of N-substituted acrylamides
DK1299348T3 (da) * 2000-06-29 2008-07-28 Emisphere Tech Inc Forbindelser og sammensætninger til levering af aktive midler
WO2002024638A1 (en) 2000-09-21 2002-03-28 Bristol-Myers Squibb Company Process for the preparation of n-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
PT1494732E (pt) 2002-03-20 2008-03-20 Mannkind Corp Aparelho de inalação
AU2003298567B9 (en) * 2002-08-29 2009-07-23 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
US7214825B2 (en) * 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
JP2005209106A (ja) * 2004-01-26 2005-08-04 Nec Corp 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体
WO2007008226A2 (en) * 2004-08-17 2007-01-18 The President And Fellows Of Harvard College Palladium-catalyzed carbon-carbon bond forming reactions
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
RU2608439C2 (ru) 2008-06-13 2017-01-18 Маннкайнд Корпорейшн Ингалятор для сухого порошка и система для доставки лекарственных средств
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
CN105579480B (zh) 2013-09-30 2019-02-22 诺华股份有限公司 用于制备吸收uv的眼用透镜的方法
CA2921303C (en) 2013-09-30 2018-04-24 Novartis Ag Silicone hydrogel lenses with relatively-long thermal stability
US9568645B2 (en) 2013-09-30 2017-02-14 Novartis Ag Silicone hydrogel lenses with relatively-long thermal stability
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3057861A (en) * 1962-10-09 Basic derivatives of trifluoromethyl-
US3084191A (en) * 1957-08-26 1963-04-02 American Cyanamid Co N-substituted acrylamide
NL297737A (cg-RX-API-DMAC10.html) * 1962-09-11
US3534099A (en) * 1967-05-25 1970-10-13 Gulf Research Development Co Process for making n - substituted and n,n-substituted carboxylic acid amides
GB1285390A (en) * 1969-12-23 1972-08-16 Pharmacia Ab Improvements in the n-alkylation of acylated amino compounds
GB1359673A (en) * 1971-06-09 1974-07-10 Procter & Gamble Ltd Quaternary ammonium compounds and surface treating compositions
US3852350A (en) * 1972-09-05 1974-12-03 Goodyear Tire & Rubber Process of preparing amides
US4008066A (en) * 1974-04-08 1977-02-15 Ciba-Geigy Corporation Phenylaminoacetamides for regulating plant growth
US4113774A (en) * 1977-09-09 1978-09-12 Sterling Drug Inc. N-(Dichloroacetyl) diamine compounds and process of preparing same
US4258196A (en) * 1978-04-17 1981-03-24 Monsanto Company Process for the production of tertiary 2-haloacetamides
US4288592A (en) * 1979-04-30 1981-09-08 American Cyanamid Company Process for preparing amides by reaction in presence of molecular sieve

Also Published As

Publication number Publication date
DE3249628C2 (cg-RX-API-DMAC10.html) 1990-12-13
DE3200648C2 (cg-RX-API-DMAC10.html) 1987-07-02
NL8200109A (nl) 1982-08-16
GB2092136A (en) 1982-08-11
US4835312A (en) 1989-05-30
DE3249630C2 (cg-RX-API-DMAC10.html) 1989-06-01
DE3200648A1 (de) 1982-09-02
DE3249628A1 (cg-RX-API-DMAC10.html) 1985-03-28
FR2498182A1 (fr) 1982-07-23
FR2498182B1 (fr) 1985-09-06
NL187805C (nl) 1992-01-16
CH648288A5 (de) 1985-03-15
NL187805B (nl) 1991-08-16

Similar Documents

Publication Publication Date Title
GB2092136B (en) Production of n-substituted amide compounds
GB2074564B (en) Amide derivatives of polyalkylpiperidines
JPS57139062A (en) Manufacture of epsilon-caprolactam
YU177182A (en) Process for obtaining n-substituted 3-0-alkyl-14-hydroxynormorphinone
IL67127A0 (en) Amide derivatives
ZA826475B (en) Manufacture of amines
HUT35661A (en) Process for the production of n-substituted flavone-8-carboxamides
JPS57158744A (en) Synthesis of amide
DE3469360D1 (en) Process for the preparation of an n-substituted carbamoyllactam compound
DE3271313D1 (en) Amide derivatives
GB2080797B (en) Amides of p-isobutyl-phenylpropionic acid
GB2141703B (en) N-glycidyl-substituted amide compounds
PL256939A1 (en) Method of obtaining novel n-substituted acyl-lactam compounds
DE3266154D1 (en) Process for the preparation of n-substituted urethanes
DE3160155D1 (en) Process for the preparation of alpha-keto-carboxylic-acid-n-tertiary-butyl amides
PL265549A1 (en) The method of manufacture of new heterocyclic amides
PL256938A1 (en) Method of obtaining novel n-substituted acyl-lactam compounds
ZA848907B (en) Novel amide compounds
PL255841A1 (en) Method of obtaining novel heterocyclic amides
JPS57169451A (en) Manufacture of 2-chloroacetoacetic acid amide
GB2119792B (en) Heterocyclic amides of phenoxyphenoxyalkanoic acids
DE3460968D1 (en) Process for the preparation of hydroxyphenylacetic-acid amides
JPS57171976A (en) Manufacture of heterocyclic compounds
DE3274452D1 (en) Process for the continuous production of 3-aminocrotonic-acid amide
DE3469175D1 (en) Production of alkyl-5-substituted-3-furoate compounds

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940107