GB201513979D0 - Synthesis of benzodiazepine derivatives - Google Patents

Synthesis of benzodiazepine derivatives

Info

Publication number
GB201513979D0
GB201513979D0 GBGB1513979.3A GB201513979A GB201513979D0 GB 201513979 D0 GB201513979 D0 GB 201513979D0 GB 201513979 A GB201513979 A GB 201513979A GB 201513979 D0 GB201513979 D0 GB 201513979D0
Authority
GB
United Kingdom
Prior art keywords
synthesis
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1513979.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TRIO MEDICINES Ltd
Original Assignee
TRIO MEDICINES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TRIO MEDICINES Ltd filed Critical TRIO MEDICINES Ltd
Priority to GBGB1513979.3A priority Critical patent/GB201513979D0/en
Publication of GB201513979D0 publication Critical patent/GB201513979D0/en
Priority to HK18115543.0A priority patent/HK1256411B/en
Priority to EP21165863.8A priority patent/EP3868746A1/en
Priority to EP16751327.4A priority patent/EP3331865B1/en
Priority to JP2018505617A priority patent/JP6979398B2/ja
Priority to PCT/GB2016/052442 priority patent/WO2017025727A1/en
Priority to US15/750,339 priority patent/US10570102B2/en
Priority to CN201680045936.3A priority patent/CN108055843A/zh
Priority to US16/741,064 priority patent/US11447454B2/en
Priority to US17/818,517 priority patent/US20230055040A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GBGB1513979.3A 2015-08-07 2015-08-07 Synthesis of benzodiazepine derivatives Ceased GB201513979D0 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GBGB1513979.3A GB201513979D0 (en) 2015-08-07 2015-08-07 Synthesis of benzodiazepine derivatives
CN201680045936.3A CN108055843A (zh) 2015-08-07 2016-08-05 苯并二氮杂*衍生物的合成
JP2018505617A JP6979398B2 (ja) 2015-08-07 2016-08-05 ベンゾジアゼピン誘導体の合成
EP21165863.8A EP3868746A1 (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives
EP16751327.4A EP3331865B1 (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives
HK18115543.0A HK1256411B (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives
PCT/GB2016/052442 WO2017025727A1 (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives
US15/750,339 US10570102B2 (en) 2015-08-07 2016-08-05 Synthesis of benzodiazepine derivatives
US16/741,064 US11447454B2 (en) 2015-08-07 2020-01-13 Synthesis of benzodiazepine derivatives
US17/818,517 US20230055040A1 (en) 2015-08-07 2022-08-09 Synthesis Of Benzodiazepine Derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1513979.3A GB201513979D0 (en) 2015-08-07 2015-08-07 Synthesis of benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
GB201513979D0 true GB201513979D0 (en) 2015-09-23

Family

ID=54200391

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1513979.3A Ceased GB201513979D0 (en) 2015-08-07 2015-08-07 Synthesis of benzodiazepine derivatives

Country Status (6)

Country Link
US (3) US10570102B2 (enExample)
EP (2) EP3331865B1 (enExample)
JP (1) JP6979398B2 (enExample)
CN (1) CN108055843A (enExample)
GB (1) GB201513979D0 (enExample)
WO (1) WO2017025727A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107162923B (zh) * 2017-06-12 2019-04-23 浙江新三和医药化工股份有限公司 一种邻氨基苯乙酮的制备方法
CN113302192A (zh) * 2019-01-17 2021-08-24 豪夫迈·罗氏有限公司 用于制备四氢吡啶并嘧啶的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138433A (en) * 1975-06-26 1979-02-06 Hoechst Aktiengesellschaft Process for preparing 1,2-oxa-phospholanes
US4081455A (en) * 1976-06-02 1978-03-28 Pfizer Inc. 6-Amino-2,2-dimethyl-3-cyanopenams
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2032226A1 (en) 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
US4994258A (en) 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
CA2056809A1 (en) 1990-12-07 1992-06-08 Mark G. Bock Benzodiazepine analogs
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
FR2682381B1 (fr) 1991-10-10 1995-04-07 Rhone Poulenc Rorer Sa Derives de benzodiazepine, leur preparation et les medicaments les contenant.
AU2759692A (en) * 1991-10-24 1993-05-21 Glaxo Group Limited Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin
CN1074216A (zh) * 1991-10-24 1993-07-14 格拉克索公司 尿素衍生物
IL104853A (en) 1992-02-27 1997-11-20 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
GB2264492B (en) 1992-02-27 1996-09-25 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
CA2130195A1 (en) 1992-03-16 1993-09-30 Mark Gary Bock Benzodiazepine derivatives, compositions containing them and their use in therapy
WO1994024151A1 (en) 1993-04-15 1994-10-27 Glaxo Inc. 1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity
GB2282594A (en) 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282595A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6562807B2 (en) * 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
CN100348196C (zh) 2001-11-13 2007-11-14 詹姆士布莱克基金会有限公司 作为胃泌激素和缩胆囊肽受体配体的苯并三氮杂䓬
WO2004101533A1 (en) 2003-05-12 2004-11-25 Janssen Pharmaceutica, N.V. 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands
US20070293482A1 (en) 2004-03-19 2007-12-20 Novartis Pharmaceuticals Corporation Process for Preparing Benzodiazepines
FR2878849B1 (fr) * 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives

Also Published As

Publication number Publication date
EP3868746A1 (en) 2021-08-25
US10570102B2 (en) 2020-02-25
US20200223807A1 (en) 2020-07-16
US20180237400A1 (en) 2018-08-23
HK1256411A1 (en) 2019-09-20
WO2017025727A1 (en) 2017-02-16
EP3331865A1 (en) 2018-06-13
JP2018523660A (ja) 2018-08-23
CN108055843A (zh) 2018-05-18
US11447454B2 (en) 2022-09-20
JP6979398B2 (ja) 2021-12-15
US20230055040A1 (en) 2023-02-23
EP3331865B1 (en) 2021-05-12

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)