JP6979398B2 - ベンゾジアゼピン誘導体の合成 - Google Patents
ベンゾジアゼピン誘導体の合成 Download PDFInfo
- Publication number
- JP6979398B2 JP6979398B2 JP2018505617A JP2018505617A JP6979398B2 JP 6979398 B2 JP6979398 B2 JP 6979398B2 JP 2018505617 A JP2018505617 A JP 2018505617A JP 2018505617 A JP2018505617 A JP 2018505617A JP 6979398 B2 JP6979398 B2 JP 6979398B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- chemical formula
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FZTMIRUSYSGPJQ-KOXFHXPQSA-N CC(C)(C)OC(N(C)C(C1)C=CC=C1NC(N[C@@H](C(N(CC(C(C)(C)COC(C)=O)=O)c1c2cccc1)=O)N=C2C1=CC(C2)C2C=N1)=O)=O Chemical compound CC(C)(C)OC(N(C)C(C1)C=CC=C1NC(N[C@@H](C(N(CC(C(C)(C)COC(C)=O)=O)c1c2cccc1)=O)N=C2C1=CC(C2)C2C=N1)=O)=O FZTMIRUSYSGPJQ-KOXFHXPQSA-N 0.000 description 1
- MZTTZGXDRPHPAX-UHFFFAOYSA-N CC(C)(C)OC(N(C)c1cccc(C(NO)O)c1)=O Chemical compound CC(C)(C)OC(N(C)c1cccc(C(NO)O)c1)=O MZTTZGXDRPHPAX-UHFFFAOYSA-N 0.000 description 1
- OAGBCZINHRYORC-YMKQNUHNSA-N CC(C)(COC(C)=O)C(CN(C(CC=CC1)C1C(c1ncccc1)=N[C@H]1N)C1O)=O Chemical compound CC(C)(COC(C)=O)C(CN(C(CC=CC1)C1C(c1ncccc1)=N[C@H]1N)C1O)=O OAGBCZINHRYORC-YMKQNUHNSA-N 0.000 description 1
- IDYIXTRGKQWPNZ-KLIMPYMGSA-N CC(C)(COC(C)=O)C(CN(C(CC=CC1C2)C12C(C1N=CCCC1)=N[C@H]1NC(NC(C2)=CC=CC2NC)=O)C1=O)=O Chemical compound CC(C)(COC(C)=O)C(CN(C(CC=CC1C2)C12C(C1N=CCCC1)=N[C@H]1NC(NC(C2)=CC=CC2NC)=O)C1=O)=O IDYIXTRGKQWPNZ-KLIMPYMGSA-N 0.000 description 1
- GPEYTRIZYSZRRK-UHFFFAOYSA-N CC(C)(COC(C)=O)C(CN(c(cccc1)c1C(c1ncccc1)=NC1NC(Nc2cc(NC)ccc2)=O)C1=O)=O Chemical compound CC(C)(COC(C)=O)C(CN(c(cccc1)c1C(c1ncccc1)=NC1NC(Nc2cc(NC)ccc2)=O)C1=O)=O GPEYTRIZYSZRRK-UHFFFAOYSA-N 0.000 description 1
- 0 CNc1cccc(NC(NC(C(N(*)c2c3cccc2)=O)N=C3c2ccccn2)=O)c1 Chemical compound CNc1cccc(NC(NC(C(N(*)c2c3cccc2)=O)N=C3c2ccccn2)=O)c1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2015/052291 WO2016020698A1 (en) | 2014-08-08 | 2015-08-07 | Benzodiazepine derivatives as cck2/gastrin receptor antagonists |
| GBGB1513979.3A GB201513979D0 (en) | 2015-08-07 | 2015-08-07 | Synthesis of benzodiazepine derivatives |
| GBPCT/GB2015/052291 | 2015-08-07 | ||
| GB1513979.3 | 2015-08-07 | ||
| PCT/GB2016/052442 WO2017025727A1 (en) | 2015-08-07 | 2016-08-05 | Synthesis of benzodiazepine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523660A JP2018523660A (ja) | 2018-08-23 |
| JP2018523660A5 JP2018523660A5 (enExample) | 2019-07-25 |
| JP6979398B2 true JP6979398B2 (ja) | 2021-12-15 |
Family
ID=54200391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018505617A Active JP6979398B2 (ja) | 2015-08-07 | 2016-08-05 | ベンゾジアゼピン誘導体の合成 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10570102B2 (enExample) |
| EP (2) | EP3331865B1 (enExample) |
| JP (1) | JP6979398B2 (enExample) |
| CN (1) | CN108055843A (enExample) |
| GB (1) | GB201513979D0 (enExample) |
| WO (1) | WO2017025727A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107162923B (zh) * | 2017-06-12 | 2019-04-23 | 浙江新三和医药化工股份有限公司 | 一种邻氨基苯乙酮的制备方法 |
| CN113302192A (zh) * | 2019-01-17 | 2021-08-24 | 豪夫迈·罗氏有限公司 | 用于制备四氢吡啶并嘧啶的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138433A (en) * | 1975-06-26 | 1979-02-06 | Hoechst Aktiengesellschaft | Process for preparing 1,2-oxa-phospholanes |
| US4081455A (en) * | 1976-06-02 | 1978-03-28 | Pfizer Inc. | 6-Amino-2,2-dimethyl-3-cyanopenams |
| CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| US4820834A (en) | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| CA2032226A1 (en) | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepine analogs |
| US4994258A (en) | 1990-03-05 | 1991-02-19 | Merck & Co., Inc. | Gamma emitting, CCK-A antagonists for pancreatic imaging |
| CA2056809A1 (en) | 1990-12-07 | 1992-06-08 | Mark G. Bock | Benzodiazepine analogs |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| FR2682381B1 (fr) | 1991-10-10 | 1995-04-07 | Rhone Poulenc Rorer Sa | Derives de benzodiazepine, leur preparation et les medicaments les contenant. |
| AU2759692A (en) * | 1991-10-24 | 1993-05-21 | Glaxo Group Limited | Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin |
| CN1074216A (zh) * | 1991-10-24 | 1993-07-14 | 格拉克索公司 | 尿素衍生物 |
| IL104853A (en) | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
| GB2264492B (en) | 1992-02-27 | 1996-09-25 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| CA2130195A1 (en) | 1992-03-16 | 1993-09-30 | Mark Gary Bock | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| WO1994024151A1 (en) | 1993-04-15 | 1994-10-27 | Glaxo Inc. | 1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity |
| GB2282594A (en) | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| GB2282595A (en) * | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| AUPO284396A0 (en) | 1996-10-08 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US6562807B2 (en) * | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| CN100348196C (zh) | 2001-11-13 | 2007-11-14 | 詹姆士布莱克基金会有限公司 | 作为胃泌激素和缩胆囊肽受体配体的苯并三氮杂䓬 |
| WO2004101533A1 (en) | 2003-05-12 | 2004-11-25 | Janssen Pharmaceutica, N.V. | 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands |
| US20070293482A1 (en) | 2004-03-19 | 2007-12-20 | Novartis Pharmaceuticals Corporation | Process for Preparing Benzodiazepines |
| FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| GB201414116D0 (en) | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
-
2015
- 2015-08-07 GB GBGB1513979.3A patent/GB201513979D0/en not_active Ceased
-
2016
- 2016-08-05 EP EP16751327.4A patent/EP3331865B1/en active Active
- 2016-08-05 EP EP21165863.8A patent/EP3868746A1/en active Pending
- 2016-08-05 US US15/750,339 patent/US10570102B2/en active Active
- 2016-08-05 JP JP2018505617A patent/JP6979398B2/ja active Active
- 2016-08-05 WO PCT/GB2016/052442 patent/WO2017025727A1/en not_active Ceased
- 2016-08-05 CN CN201680045936.3A patent/CN108055843A/zh active Pending
-
2020
- 2020-01-13 US US16/741,064 patent/US11447454B2/en active Active
-
2022
- 2022-08-09 US US17/818,517 patent/US20230055040A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3868746A1 (en) | 2021-08-25 |
| US10570102B2 (en) | 2020-02-25 |
| US20200223807A1 (en) | 2020-07-16 |
| US20180237400A1 (en) | 2018-08-23 |
| HK1256411A1 (en) | 2019-09-20 |
| WO2017025727A1 (en) | 2017-02-16 |
| GB201513979D0 (en) | 2015-09-23 |
| EP3331865A1 (en) | 2018-06-13 |
| JP2018523660A (ja) | 2018-08-23 |
| CN108055843A (zh) | 2018-05-18 |
| US11447454B2 (en) | 2022-09-20 |
| US20230055040A1 (en) | 2023-02-23 |
| EP3331865B1 (en) | 2021-05-12 |
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