GB201214220D0 - Radiosynthesis - Google Patents

Radiosynthesis

Info

Publication number
GB201214220D0
GB201214220D0 GBGB1214220.4A GB201214220A GB201214220D0 GB 201214220 D0 GB201214220 D0 GB 201214220D0 GB 201214220 A GB201214220 A GB 201214220A GB 201214220 D0 GB201214220 D0 GB 201214220D0
Authority
GB
United Kingdom
Prior art keywords
radiosynthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1214220.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to GBGB1214220.4A priority Critical patent/GB201214220D0/en
Publication of GB201214220D0 publication Critical patent/GB201214220D0/en
Priority to MX2019012139A priority patent/MX388930B/es
Priority to PCT/EP2013/066570 priority patent/WO2014023775A1/en
Priority to EP13750668.9A priority patent/EP2885271A1/en
Priority to KR1020157003004A priority patent/KR102109225B1/ko
Priority to IN10962DEN2014 priority patent/IN2014DN10962A/en
Priority to JP2015525884A priority patent/JP6574379B2/ja
Priority to MX2015001724A priority patent/MX368668B/es
Priority to AU2013301499A priority patent/AU2013301499B2/en
Priority to CN201810568649.1A priority patent/CN108997169A/zh
Priority to US14/420,493 priority patent/US9359288B2/en
Priority to GB1501016.8A priority patent/GB2519026B/en
Priority to CN201380041838.9A priority patent/CN104507905A/zh
Priority to BR112015002077A priority patent/BR112015002077A2/pt
Priority to CA2878636A priority patent/CA2878636A1/en
Priority to RU2015101998A priority patent/RU2640805C2/ru
Priority to IL236312A priority patent/IL236312A0/en
Priority to US15/173,839 priority patent/US10023525B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J16/00—Chemical processes in general for reacting liquids with non- particulate solids, e.g. sheet material; Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/245—Stationary reactors without moving elements inside placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside
    • B01J2219/2401—Reactors comprising multiple separate flow channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
GBGB1214220.4A 2012-08-09 2012-08-09 Radiosynthesis Ceased GB201214220D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GBGB1214220.4A GB201214220D0 (en) 2012-08-09 2012-08-09 Radiosynthesis
RU2015101998A RU2640805C2 (ru) 2012-08-09 2013-08-07 Получение 18F-флуцикловина
AU2013301499A AU2013301499B2 (en) 2012-08-09 2013-08-07 Preparation of 18F-fluciclovine
US14/420,493 US9359288B2 (en) 2012-08-09 2013-08-07 Preparation of 18F-fluciclovine
EP13750668.9A EP2885271A1 (en) 2012-08-09 2013-08-07 Preparation of 18f-fluciclovine
KR1020157003004A KR102109225B1 (ko) 2012-08-09 2013-08-07 18f-플루시클로빈의 제조
IN10962DEN2014 IN2014DN10962A (cg-RX-API-DMAC7.html) 2012-08-09 2013-08-07
JP2015525884A JP6574379B2 (ja) 2012-08-09 2013-08-07 １８ｆ−フルシクロビンの製造
MX2015001724A MX368668B (es) 2012-08-09 2013-08-07 Preparacion de 18f-fluciclovina.
MX2019012139A MX388930B (es) 2012-08-09 2013-08-07 Preparacion de 18f-fluciclovina.
CN201810568649.1A CN108997169A (zh) 2012-08-09 2013-08-07 制备18F-Fluciclovine
PCT/EP2013/066570 WO2014023775A1 (en) 2012-08-09 2013-08-07 Preparation of 18f-fluciclovine
GB1501016.8A GB2519026B (en) 2012-08-09 2013-08-07 Preparation of 18F-fluciclovine
CN201380041838.9A CN104507905A (zh) 2012-08-09 2013-08-07 制备18F-Fluciclovine
BR112015002077A BR112015002077A2 (pt) 2012-08-09 2013-08-07 método para preparar ácido 1-amino-3-[18f]-fluorociclobutano carboxílico, e, sistema e cassete para realizar o método
CA2878636A CA2878636A1 (en) 2012-08-09 2013-08-07 Preparation of 18f-fluciclovine
IL236312A IL236312A0 (en) 2012-08-09 2014-12-17 Preparation of 18f-fluciclovine
US15/173,839 US10023525B2 (en) 2012-08-09 2016-06-06 Preparation of 18F-fluciclovine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1214220.4A GB201214220D0 (en) 2012-08-09 2012-08-09 Radiosynthesis

Publications (1)

Publication Number Publication Date
GB201214220D0 true GB201214220D0 (en) 2012-09-19

Family

ID=46935146

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1214220.4A Ceased GB201214220D0 (en) 2012-08-09 2012-08-09 Radiosynthesis
GB1501016.8A Active GB2519026B (en) 2012-08-09 2013-08-07 Preparation of 18F-fluciclovine

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1501016.8A Active GB2519026B (en) 2012-08-09 2013-08-07 Preparation of 18F-fluciclovine

Country Status (14)

Country Link
US (2) US9359288B2 (cg-RX-API-DMAC7.html)
EP (1) EP2885271A1 (cg-RX-API-DMAC7.html)
JP (1) JP6574379B2 (cg-RX-API-DMAC7.html)
KR (1) KR102109225B1 (cg-RX-API-DMAC7.html)
CN (2) CN108997169A (cg-RX-API-DMAC7.html)
AU (1) AU2013301499B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015002077A2 (cg-RX-API-DMAC7.html)
CA (1) CA2878636A1 (cg-RX-API-DMAC7.html)
GB (2) GB201214220D0 (cg-RX-API-DMAC7.html)
IL (1) IL236312A0 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN10962A (cg-RX-API-DMAC7.html)
MX (2) MX388930B (cg-RX-API-DMAC7.html)
RU (1) RU2640805C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014023775A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504430B2 (en) * 2010-12-29 2022-11-22 Ge Healthcare Limited Eluent solution
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201214220D0 (en) 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
US20180170822A1 (en) * 2015-06-05 2018-06-21 Nihon Medi-Physics Co., Ltd. Device and method for producing radioactively labeled compound
GB201621864D0 (en) 2016-12-21 2017-02-01 Ge Healthcare Ltd Solid phase conditioning
CN106770883B (zh) * 2017-01-03 2019-01-29 原子高科股份有限公司 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
JP4550141B2 (ja) * 2006-05-11 2010-09-22 日本メジフィジックス株式会社 放射性フッ素標識有機化合物の製造方法
JP5518337B2 (ja) * 2006-12-27 2014-06-11 日本メジフィジックス株式会社 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
JP5258583B2 (ja) 2007-02-13 2013-08-07 日本メジフィジックス株式会社 放射性画像診断剤の製造方法
BRPI0821241B1 (pt) 2007-12-19 2021-04-06 Nihon Medi-Physics Co., Ltd. Processo para a produção de um composto orgânico marcado com flúor radioativo
AU2010303355B2 (en) * 2009-10-08 2015-09-03 Ge Healthcare Limited Purification method
RU2587308C2 (ru) 2010-11-29 2016-06-20 ДжиИ ХЕЛТКЕР ЛИМИТЕД Получение предшественника для пэт
US9061977B2 (en) 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
GB201021530D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201021523D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
US11504430B2 (en) 2010-12-29 2022-11-22 Ge Healthcare Limited Eluent solution
GB201214220D0 (en) 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Also Published As

Publication number Publication date
GB201501016D0 (en) 2015-03-04
WO2014023775A1 (en) 2014-02-13
BR112015002077A2 (pt) 2017-07-04
GB2519026A (en) 2015-04-08
US20150232415A1 (en) 2015-08-20
US10023525B2 (en) 2018-07-17
CN108997169A (zh) 2018-12-14
KR102109225B1 (ko) 2020-05-11
MX2019012139A (es) 2019-12-09
EP2885271A1 (en) 2015-06-24
US9359288B2 (en) 2016-06-07
RU2015101998A (ru) 2016-09-27
CN104507905A (zh) 2015-04-08
IN2014DN10962A (cg-RX-API-DMAC7.html) 2015-09-18
RU2640805C2 (ru) 2018-01-12
AU2013301499A1 (en) 2015-01-22
GB2519026B (en) 2019-09-04
IL236312A0 (en) 2015-02-26
MX368668B (es) 2019-10-10
US20160355460A1 (en) 2016-12-08
MX2015001724A (es) 2015-04-14
AU2013301499B2 (en) 2017-08-31
MX388930B (es) 2025-03-20
JP6574379B2 (ja) 2019-09-11
JP2015530985A (ja) 2015-10-29
KR20150039204A (ko) 2015-04-09
CA2878636A1 (en) 2014-02-13

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)