GB201101621D0 - Method and product - Google Patents

Method and product

Info

Publication number
GB201101621D0
GB201101621D0 GBGB1101621.9A GB201101621A GB201101621D0 GB 201101621 D0 GB201101621 D0 GB 201101621D0 GB 201101621 A GB201101621 A GB 201101621A GB 201101621 D0 GB201101621 D0 GB 201101621D0
Authority
GB
United Kingdom
Prior art keywords
proximity
analyte
probes
sample
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1101621.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olink Holding AB
Original Assignee
Olink AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olink AB filed Critical Olink AB
Priority to GBGB1101621.9A priority Critical patent/GB201101621D0/en
Publication of GB201101621D0 publication Critical patent/GB201101621D0/en
Priority to EP12702018.8A priority patent/EP2670860B1/en
Priority to CN201280006856.9A priority patent/CN103354840B/zh
Priority to US13/981,943 priority patent/US9777315B2/en
Priority to JP2013550902A priority patent/JP6180940B2/ja
Priority to PCT/EP2012/051474 priority patent/WO2012104261A1/en
Priority to EP17183834.5A priority patent/EP3323896B1/en
Priority to JP2017019754A priority patent/JP6457564B2/ja
Priority to US15/693,582 priority patent/US10731206B2/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
GBGB1101621.9A 2011-01-31 2011-01-31 Method and product Ceased GB201101621D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB1101621.9A GB201101621D0 (en) 2011-01-31 2011-01-31 Method and product
EP12702018.8A EP2670860B1 (en) 2011-01-31 2012-01-30 Exonuclease enabled proximity extension assays
CN201280006856.9A CN103354840B (zh) 2011-01-31 2012-01-30 核酸外切酶可实现的邻近延伸分析
US13/981,943 US9777315B2 (en) 2011-01-31 2012-01-30 Exonuclease enabled proximity extension assays
JP2013550902A JP6180940B2 (ja) 2011-01-31 2012-01-30 エキソヌクレアーゼを用いた近接伸長アッセイ
PCT/EP2012/051474 WO2012104261A1 (en) 2011-01-31 2012-01-30 Exonuclease enabled proximity extension assays
EP17183834.5A EP3323896B1 (en) 2011-01-31 2012-01-30 Exonuclease enabled proximity extension assays
JP2017019754A JP6457564B2 (ja) 2011-01-31 2017-02-06 エキソヌクレアーゼを用いた近接伸長アッセイ
US15/693,582 US10731206B2 (en) 2011-01-31 2017-09-01 Exonuclease enabled proximity extension assays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1101621.9A GB201101621D0 (en) 2011-01-31 2011-01-31 Method and product

Publications (1)

Publication Number Publication Date
GB201101621D0 true GB201101621D0 (en) 2011-03-16

Family

ID=43824847

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1101621.9A Ceased GB201101621D0 (en) 2011-01-31 2011-01-31 Method and product

Country Status (6)

Country Link
US (2) US9777315B2 (enExample)
EP (2) EP2670860B1 (enExample)
JP (2) JP6180940B2 (enExample)
CN (1) CN103354840B (enExample)
GB (1) GB201101621D0 (enExample)
WO (1) WO2012104261A1 (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2542890B1 (en) 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
GB201101621D0 (en) * 2011-01-31 2011-03-16 Olink Ab Method and product
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CN105121659A (zh) * 2013-03-15 2015-12-02 富鲁达公司 单细胞中的靶蛋白和靶核酸的同时检测
TWI553122B (zh) 2013-05-21 2016-10-11 Src公司 用於分子與蛋白質基於螢光之定量偵測的方法與系統
CA2922926A1 (en) 2013-09-04 2015-03-12 Fluidigm Corporation Proximity assays for detecting nucleic acids and proteins in a single cell
GB201401885D0 (en) * 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
US10112194B2 (en) 2014-04-14 2018-10-30 Q-Linea Ab Detection of microscopic objects
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
GB201414745D0 (en) 2014-08-19 2014-10-01 Articzymes As Exonucleases
CN105483115A (zh) * 2014-09-19 2016-04-13 深圳华大基因科技有限公司 一种用于单细胞全基因组扩增的试剂盒及其应用
CN104293930B (zh) * 2014-09-28 2016-07-06 南京诺唯赞生物科技有限公司 一种3’-5’外切酶活性测定方法
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
KR102741603B1 (ko) 2016-05-02 2024-12-16 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP3464633A4 (en) * 2016-05-25 2020-01-01 Bio-Rad Laboratories, Inc. DIGITAL PROXIMITY TEST
CN109312337B (zh) 2016-05-27 2022-10-04 哈佛学院院长及董事 用于单分子检测的条件性引物延伸
CN116064727A (zh) 2016-07-27 2023-05-05 斯坦福大学托管董事会 高度复用荧光成像
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
US20200264188A1 (en) 2017-09-13 2020-08-20 Progenity, Inc. Preeclampsia biomarkers and related systems and methods
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
JP7096893B2 (ja) * 2018-02-05 2022-07-06 エフ.ホフマン-ラ ロシュ アーゲー 単一分子のための一本鎖環状dna鋳型の作製
CN112941155B (zh) * 2018-05-14 2023-07-14 北京艾克伦医疗科技有限公司 具有茎环结构的dna引物对及其应用
CN112243462B (zh) * 2018-06-06 2025-02-25 加利福尼亚大学董事会 产生核酸文库的方法以及用于实践所述方法的组合物和试剂盒
WO2019238944A1 (en) 2018-06-15 2019-12-19 Olink Proteomics Ab Biomarker panel for ovarian cancer
JP2022512058A (ja) * 2018-12-21 2022-02-02 イルミナ インコーポレイテッド ヌクレアーゼを利用したrna枯渇
CN113302301A (zh) * 2019-01-09 2021-08-24 凯杰科学有限责任公司 检测分析物的方法及其组合物
EP3998349A3 (en) 2019-03-01 2022-08-24 Mercy Bioanalytics, Inc. Compositions and methods for target protein detection on exosomes using proximal ligation
WO2020220013A1 (en) * 2019-04-26 2020-10-29 Arizona Board Of Regents On Behalf Of Arizona State University Proximity-driven activation of crispr-cas systems for detection of diverse molecular analytes
EP3963070A4 (en) 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
EP4069731A4 (en) 2019-12-03 2024-05-29 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
EP4225946A4 (en) * 2020-10-06 2024-10-30 President And Fellows Of Harvard College METHODS, COMPOSITIONS, KITS AND SYSTEMS FOR SIGNAL-BASED DETECTION OF NEUTRALIZATION TARGETS
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
KR102573998B1 (ko) * 2020-12-30 2023-09-04 주식회사 스타노스 위양성 신호가 제거된 항원 검출방법 및 키트
US12092642B2 (en) 2021-01-20 2024-09-17 Nautilus Subsidiary, Inc. Systems and methods for biomolecule quantitation
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
US20230035685A1 (en) * 2021-07-30 2023-02-02 10X Genomics, Inc. One step in situ rolling circle amplification assay
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
CN120858284A (zh) 2023-01-27 2025-10-28 生物梅里埃公司 用于更快生物标志物检测的改良的免疫分子测定
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
WO2025012398A1 (en) 2023-07-11 2025-01-16 Olink Proteomics Ab Dried reagents
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025111398A1 (en) 2023-11-20 2025-05-30 Alamar Biosciences, Inc. Reduction of non-cognate signal in multiplex proximity ligation assays
WO2025111397A1 (en) 2023-11-20 2025-05-30 Alamar Biosciences, Inc. Use of autoinhibition standard curves in proximity assays
WO2025111396A1 (en) 2023-11-20 2025-05-30 Alamar Biosciences, Inc. Molecular barcode set and use thereof in multiplex proximity detection assays
CN117343999B (zh) * 2023-12-05 2024-03-01 上海锐赛循益生物技术有限公司 基于左侧探针退火和右侧探针退火延伸的核酸扩增方法
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025168224A1 (en) 2024-02-08 2025-08-14 Leica Microsystems Cms Gmbh Marker and method for analysing a biological sample
WO2025199005A1 (en) 2024-03-20 2025-09-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biomarkers for identifying cancer patients at high risk for chemotherapy-induced cardiotoxicity
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4883867A (en) 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5449603A (en) 1989-10-24 1995-09-12 Stratagene Method for hybridizing nucleic acids using single-stranded nucleic acid binding protein
US5733523A (en) 1990-12-10 1998-03-31 Akzo Nobel N.V. Targeted delivery of a therapeutic entity using complementary oligonucleotides
AU672367B2 (en) 1991-09-13 1996-10-03 British Biocell International Limited Nucleic acids extension assay
ATE152831T1 (de) 1991-09-16 1997-05-15 Molecular Probes Inc Dimere unsymmetrische cyaninfarbstoffe
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
AU3595493A (en) 1992-01-28 1993-09-01 President And Fellors Of Harvard College Method for nucleic acid hybridization using single-stranded DNA binding protein
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
EP0651805B1 (en) 1992-07-17 2006-12-13 Dana Farber Cancer Institute Method of intracellular binding of target molecules
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5271099A (en) 1992-11-02 1993-12-21 Lin Ming Huei Sunshade cap with a double layer visor
US5410030A (en) 1993-04-05 1995-04-25 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes containing pyridinium moieties
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5440016A (en) 1993-06-18 1995-08-08 Torrey Pines Institute For Molecular Studies Peptides of the formula (KFmoc) ZZZ and their uses
US5851829A (en) 1993-07-16 1998-12-22 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
US5635602A (en) 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US5688997A (en) 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5688696A (en) 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
EP0839152B1 (en) 1995-06-21 2002-03-13 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5731423A (en) 1996-03-21 1998-03-24 Transcell Technologies, Inc. Process for preparing sulfoxides
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
ES2209145T5 (es) 1997-05-28 2009-10-30 Crescendo Biologics Ltd. Complejos de ribosomas como particulas de seleccion para el desarrollo in vitro y evolucion de proteinas.
ES2290979T3 (es) 1997-12-15 2008-02-16 Csl Behring Gmbh Cebador marcado para uso en la deteccion de acidos nucleicos diana.
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
JP4493844B2 (ja) * 1998-03-25 2010-06-30 ランデグレン、ウルフ 錠型(padlock)プローブのローリングサークル複製
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
SE516272C2 (sv) 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
EP1451356A1 (en) 2001-11-23 2004-09-01 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US20050221349A1 (en) 2002-05-30 2005-10-06 Stuart Wilson Methods of detecting target molecules and molecular interactions
CN101410530B (zh) 2003-04-18 2013-03-27 贝克顿·迪金森公司 免疫-扩增
US7914987B2 (en) 2004-06-14 2011-03-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
JP5188808B2 (ja) * 2004-11-03 2013-04-24 アイリス モレキュラー ダイアグノスティクス, インコーポレイテッド 同種の分析物検出
WO2007005649A2 (en) 2005-06-30 2007-01-11 Applera Corporation Proximity probing of target proteins comprising restriction and/or extension field
US20080293051A1 (en) 2005-08-30 2008-11-27 Board Of Regents, The University Of Texas System proximity ligation assay
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US20080090238A1 (en) 2006-10-12 2008-04-17 Dan-Hui Dorothy Yang Increased sensitivity of proximity ligation assays
JP2010533867A (ja) 2007-07-17 2010-10-28 アジレント テクノロジーズ インコーポレイテッド 分析物検出アッセイ
US7659069B2 (en) 2007-08-31 2010-02-09 Agilent Technologies, Inc. Binary signaling assay using a split-polymerase
JP2010539942A (ja) 2007-09-28 2010-12-24 アフォミックス コーポレイション タンパク質を複合体化するためのポリヌクレオチド骨格
WO2009123216A1 (ja) * 2008-03-31 2009-10-08 独立行政法人理化学研究所 高選択・高効率でpcr増幅が可能な新規dna
US9040287B2 (en) * 2010-02-12 2015-05-26 Mediomics, Llc Molecular biosensors capable of signal amplification
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
GB201101621D0 (en) * 2011-01-31 2011-03-16 Olink Ab Method and product

Also Published As

Publication number Publication date
JP6180940B2 (ja) 2017-08-16
US20180100189A1 (en) 2018-04-12
US9777315B2 (en) 2017-10-03
CN103354840B (zh) 2016-06-08
JP6457564B2 (ja) 2019-01-23
EP3323896A2 (en) 2018-05-23
EP3323896A3 (en) 2018-06-13
CN103354840A (zh) 2013-10-16
EP2670860B1 (en) 2017-08-16
WO2012104261A1 (en) 2012-08-09
US10731206B2 (en) 2020-08-04
JP2017108749A (ja) 2017-06-22
EP3323896B1 (en) 2020-05-27
EP2670860A1 (en) 2013-12-11
US20140030721A1 (en) 2014-01-30
JP2014504880A (ja) 2014-02-27

Similar Documents

Publication Publication Date Title
GB201101621D0 (en) Method and product
GB201201547D0 (en) Method and product
ATE457065T1 (de) Verfahren zum analytennachweis unter verwendung von proximitätssonden
WO2005123963A3 (en) Methods and compositions for use in analyte detection using proximity probes
NZ629703A (en) Methods and compositions for detecting multiple analytes with a single signal
WO2006126008A3 (en) Improved immunoassay methods
ATE402269T1 (de) Methoden und testsätze für annäherungstest
MX2010010161A (es) Composiciones y metodos para el analisis de moleculas de acido nucleico durante reacciones de amplificacion.
DE602006018477D1 (de) Dna und antikörpern sowie verwendungen davon
NZ590161A (en) Device and methods for detecting analytes in saliva by removing mucin before analysis
MY170164A (en) Aptamer-based multiplexed assays
RU2009101049A (ru) Повышенная специфичность детектирования анализируемого вещества путем измерения связанных и не связанных меток
WO2011014879A3 (en) Assay tools and methods of use
WO2009012220A3 (en) Analyte detection assays
WO2011147563A9 (de) Verfahren zur elektrochemischen detektion von bindungsreaktionen
WO2012159072A3 (en) Fluorescent molecular probes for use in assays that measure test compound competitive binding with sam-utilizing proteins
UA119466C2 (uk) Спосіб виявлення активних форм аналіту та визначення здатності речовин зв'язуватися з активними центрами аналіту
DE502005005132D1 (de) Verfahren zur erhöhung des dynamischen messbereichs von auf spezifischen bindereaktionen basierenden, insbesondere immunologischen testelementen
WO2014018278A3 (en) Multisignal reagents for labeling analytes
MX2009010751A (es) Composiciones y metodos de deteccion.
MX2016013462A (es) Metodos y dispositivos para deteccion de resistencia a un inhibidor de enzima.
WO2009121024A3 (en) Methods for detecting antibodies
ATE529533T1 (de) Verfahren zum nachweis von analyten in einer probe
ZA201705365B (en) Homogenous immunoassay with compensation for background signal
WO2007044903A3 (en) Binary signal detection assays

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)