ATE457065T1 - Verfahren zum analytennachweis unter verwendung von proximitätssonden - Google Patents

Verfahren zum analytennachweis unter verwendung von proximitätssonden

Info

Publication number
ATE457065T1
ATE457065T1 AT07732076T AT07732076T ATE457065T1 AT E457065 T1 ATE457065 T1 AT E457065T1 AT 07732076 T AT07732076 T AT 07732076T AT 07732076 T AT07732076 T AT 07732076T AT E457065 T1 ATE457065 T1 AT E457065T1
Authority
AT
Austria
Prior art keywords
proximity
analyte
nucleic acid
probes
proximity probe
Prior art date
Application number
AT07732076T
Other languages
English (en)
Inventor
Edith Schallmeiner
Original Assignee
Olink Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olink Ab filed Critical Olink Ab
Application granted granted Critical
Publication of ATE457065T1 publication Critical patent/ATE457065T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
AT07732076T 2006-03-20 2007-03-20 Verfahren zum analytennachweis unter verwendung von proximitätssonden ATE457065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0605584.2A GB0605584D0 (en) 2006-03-20 2006-03-20 Method for analyte detection using proximity probes
PCT/GB2007/000984 WO2007107743A1 (en) 2006-03-20 2007-03-20 Method for analyte detection using proximity probes

Publications (1)

Publication Number Publication Date
ATE457065T1 true ATE457065T1 (de) 2010-02-15

Family

ID=36293119

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07732076T ATE457065T1 (de) 2006-03-20 2007-03-20 Verfahren zum analytennachweis unter verwendung von proximitätssonden

Country Status (7)

Country Link
US (1) US8268554B2 (de)
EP (1) EP1996941B1 (de)
JP (1) JP5144639B2 (de)
AT (1) ATE457065T1 (de)
DE (1) DE602007004666D1 (de)
GB (1) GB0605584D0 (de)
WO (1) WO2007107743A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
US8034569B2 (en) * 2008-06-06 2011-10-11 Biotex, Inc. Methods for molecular detection
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
CN106771219B (zh) 2010-06-17 2020-04-07 皇家飞利浦电子股份有限公司 多表位测定
WO2012006556A2 (en) * 2010-07-08 2012-01-12 Life Technologies Corporation Detection of analytes
GB201011971D0 (en) * 2010-07-15 2010-09-01 Olink Ab Methods and product
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
EP2633081B1 (de) * 2010-10-29 2017-01-11 Olink Bioscience AB Näherungsligationstechnologie für western-blot-anwendungen
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
US9804179B2 (en) 2011-01-08 2017-10-31 Access Medical Systems, Ltd. Systems for immunoassay tests
ES2805874T3 (es) 2011-01-17 2021-02-15 Life Technologies Corp Ligación enzimática de ácidos nucleicos
EP2665833B1 (de) * 2011-01-17 2017-04-19 Life Technologies Corporation Arbeitsablauf zur nachweis von liganden mit nukleinsäuren
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
WO2013096851A1 (en) 2011-12-22 2013-06-27 President And Fellows Of Harvard College Compositions and methods for analyte detection
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US9029086B2 (en) 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) * 2012-01-30 2012-03-14 Olink Ab Method and product
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
EP2971184B1 (de) 2013-03-12 2019-04-17 President and Fellows of Harvard College Verfahren zur erzeugung einer dreidimensionalen nukleinsäure mit matrix
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP2971183A4 (de) 2013-03-13 2016-10-26 Meso Scale Technologies Llc Verbesserte testverfahren
US9593364B2 (en) 2013-05-21 2017-03-14 Src, Inc. Detecting a target molecule in a sample using a dual-antibody quantitative fluorescence-based detection method
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
WO2014210376A1 (en) * 2013-06-27 2014-12-31 The Board Of Trustees Of The Leland Stanford Junior University Dna-conjugated antibodies for improved antibody affinity and reduced antibody cross reactivity
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
KR20230022268A (ko) 2014-05-15 2023-02-14 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
DE102014209393B4 (de) * 2014-05-19 2016-02-04 Trumpf Werkzeugmaschinen Gmbh + Co. Kg Verfahren zum maschinellen Bearbeiten eines plattenartigen Werkstücks, insbesondere einer Blechtafel
MX2017003790A (es) * 2014-09-26 2017-08-07 Two Pore Guys Inc Detección de secuencias diana por percepción de nanoporos de sondas sintéticas.
JP6828007B2 (ja) 2015-04-10 2021-02-10 スペーシャル トランスクリプトミクス アクチボラグ 生物学的試料の空間識別されるマルチプレックスな核酸分析
EP3933047A1 (de) 2015-09-24 2022-01-05 AbVitro LLC Affinitätsoligonukleotidkonjugate und verwendungen davon
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
WO2017079406A1 (en) 2015-11-03 2017-05-11 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
CN109415761B (zh) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
CN109154021A (zh) * 2016-05-25 2019-01-04 生物辐射实验室股份有限公司 数字邻近试验
US11352667B2 (en) 2016-06-21 2022-06-07 10X Genomics, Inc. Nucleic acid sequencing
JP7057348B2 (ja) 2016-08-31 2022-04-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光in situ配列決定を用いた単一アッセイに生体分子の検出を組み合わせる方法
WO2018045181A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
BR112019005748A2 (pt) 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
CN110249082B (zh) 2016-12-01 2023-07-07 诺迪勒思附属公司 测定蛋白质的方法
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
ES2917500T3 (es) * 2017-03-01 2022-07-08 Univ Leland Stanford Junior Ensayo de ligadura de proximidad circular altamente específico
GB201703625D0 (en) * 2017-03-07 2017-04-19 Quantumdx Group Ltd Aptamer based methods for protein detection
CN111263819A (zh) 2017-10-06 2020-06-09 卡特阿纳公司 Rna模板化连接
EP3775265B1 (de) 2018-04-03 2024-03-27 Nomic Bio Inc. Sandwich-assays mit kolokalisierung durch verknüpfung
US20210255189A1 (en) 2018-06-15 2021-08-19 Olink Proteomics Ab Biomarker panel for ovarian cancer
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
EP3894586A2 (de) 2018-12-10 2021-10-20 10X Genomics, Inc. Verfahren zur bestimmung des ortes eines biologischen analyten in einer biologischen probe
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
AU2020233286B2 (en) 2019-03-01 2022-10-20 Mercy Bioanalytics, Inc. Systems, compositions, and methods for target entity detection
EP3976820A1 (de) 2019-05-30 2022-04-06 10X Genomics, Inc. Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe
CN113906147A (zh) 2019-05-31 2022-01-07 10X基因组学有限公司 检测目标核酸分子的方法
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP3891300B1 (de) 2019-12-23 2023-03-29 10X Genomics, Inc. Verfahren zur räumlichen analyse mittels rna-template-ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
WO2021191442A1 (en) 2020-03-27 2021-09-30 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
EP4242325A3 (de) 2020-04-22 2023-10-04 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4162074B1 (de) 2020-06-08 2024-04-24 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
US11935311B2 (en) 2020-06-11 2024-03-19 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
AU2022210423A1 (en) 2021-01-20 2023-07-06 Nautilus Subsidiary, Inc. Methods for biomolecule quantitation
EP4281775A1 (de) 2021-01-21 2023-11-29 Nautilus Subsidiary, Inc. Systeme und verfahren zur biomolekülherstellung
IL305336A (en) 2021-03-11 2023-10-01 Nautilus Subsidiary Inc Systems and methods for the preservation of biomolecules
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
CA3227592A1 (en) 2021-09-22 2023-03-30 Gregory KAPP Methods and systems for determining polypeptide interactions
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240094215A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4883867A (en) 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5449603A (en) 1989-10-24 1995-09-12 Stratagene Method for hybridizing nucleic acids using single-stranded nucleic acid binding protein
US5733523A (en) 1990-12-10 1998-03-31 Akzo Nobel N.V. Targeted delivery of a therapeutic entity using complementary oligonucleotides
CA2119126C (en) 1991-09-16 1996-09-03 Stephen T. Yue Dimers of unsymmetrical cyanine dyes
WO1993006121A1 (en) 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
AU3595493A (en) 1992-01-28 1993-09-01 President And Fellors Of Harvard College Method for nucleic acid hybridization using single-stranded DNA binding protein
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
ATE348175T1 (de) 1992-07-17 2007-01-15 Dana Farber Cancer Inst Inc Method eder intrazellularen bindung von zielgerichteten molekülen
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5410030A (en) 1993-04-05 1995-04-25 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes containing pyridinium moieties
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5440016A (en) 1993-06-18 1995-08-08 Torrey Pines Institute For Molecular Studies Peptides of the formula (KFmoc) ZZZ and their uses
US5851829A (en) 1993-07-16 1998-12-22 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US5688997A (en) 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5688696A (en) 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
US5565974A (en) * 1995-03-31 1996-10-15 Xerox Corporation Penta-level xerographic unit
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
DE69619825T2 (de) 1995-06-21 2002-10-10 Martek Biosciences Corp Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung
US5731423A (en) 1996-03-21 1998-03-24 Transcell Technologies, Inc. Process for preparing sulfoxides
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
CA2291721C (en) 1997-05-28 2011-08-09 Babraham Institute Ribosome complexes as selection particles for in vitro display and evolution of proteins
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
EP0930370B1 (de) 1997-12-15 2007-08-08 CSL Behring GmbH Markierter Primer, geeignet für die Detektion von Nukleinsäuren
JP4493844B2 (ja) 1998-03-25 2010-06-30 ランデグレン、ウルフ 錠型(padlock)プローブのローリングサークル複製
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
SE516272C2 (sv) * 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
ATE380883T1 (de) 2000-10-24 2007-12-15 Univ Leland Stanford Junior Direkte multiplex charakterisierung von genomischer dna
EP1249500A1 (de) * 2001-04-12 2002-10-16 chimera biotec GmbH Verfahren zum Nachweis einer Substanz
EP1451356A1 (de) 2001-11-23 2004-09-01 Simon Fredriksson Verfahren und kit zur proximitätssondierung mit mehrwertigen proximitätssonden
US7914987B2 (en) * 2004-06-14 2011-03-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
WO2007044903A2 (en) 2005-10-11 2007-04-19 Stratagene California Binary signal detection assays
EP2179290B1 (de) 2007-07-17 2013-12-11 Agilent Technologies, Inc. Analytnachweistests

Also Published As

Publication number Publication date
EP1996941B1 (de) 2010-02-03
WO2007107743A1 (en) 2007-09-27
JP2009529904A (ja) 2009-08-27
US20100021890A1 (en) 2010-01-28
US8268554B2 (en) 2012-09-18
DE602007004666D1 (de) 2010-03-25
GB0605584D0 (en) 2006-04-26
JP5144639B2 (ja) 2013-02-13
EP1996941A1 (de) 2008-12-03

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