ATE457065T1 - Verfahren zum analytennachweis unter verwendung von proximitätssonden - Google Patents

Verfahren zum analytennachweis unter verwendung von proximitätssonden

Info

Publication number
ATE457065T1
ATE457065T1 AT07732076T AT07732076T ATE457065T1 AT E457065 T1 ATE457065 T1 AT E457065T1 AT 07732076 T AT07732076 T AT 07732076T AT 07732076 T AT07732076 T AT 07732076T AT E457065 T1 ATE457065 T1 AT E457065T1
Authority
AT
Austria
Prior art keywords
proximity
analyte
nucleic acid
probes
proximity probe
Prior art date
Application number
AT07732076T
Other languages
English (en)
Inventor
Edith Schallmeiner
Original Assignee
Olink Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olink Ab filed Critical Olink Ab
Application granted granted Critical
Publication of ATE457065T1 publication Critical patent/ATE457065T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Prostheses (AREA)
  • Geophysics And Detection Of Objects (AREA)
AT07732076T 2006-03-20 2007-03-20 Verfahren zum analytennachweis unter verwendung von proximitätssonden ATE457065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0605584.2A GB0605584D0 (en) 2006-03-20 2006-03-20 Method for analyte detection using proximity probes
PCT/GB2007/000984 WO2007107743A1 (en) 2006-03-20 2007-03-20 Method for analyte detection using proximity probes

Publications (1)

Publication Number Publication Date
ATE457065T1 true ATE457065T1 (de) 2010-02-15

Family

ID=36293119

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07732076T ATE457065T1 (de) 2006-03-20 2007-03-20 Verfahren zum analytennachweis unter verwendung von proximitätssonden

Country Status (7)

Country Link
US (1) US8268554B2 (de)
EP (1) EP1996941B1 (de)
JP (1) JP5144639B2 (de)
AT (1) ATE457065T1 (de)
DE (1) DE602007004666D1 (de)
GB (1) GB0605584D0 (de)
WO (1) WO2007107743A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
US8034569B2 (en) * 2008-06-06 2011-10-11 Biotex, Inc. Methods for molecular detection
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CN106771219B (zh) 2010-06-17 2020-04-07 皇家飞利浦电子股份有限公司 多表位测定
WO2012006556A2 (en) * 2010-07-08 2012-01-12 Life Technologies Corporation Detection of analytes
GB201011971D0 (en) * 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
WO2012057689A1 (en) * 2010-10-29 2012-05-03 Ge Healthcare Bio-Sciences Ab Proximity ligation technology for western blot applications
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
US9804179B2 (en) * 2011-01-08 2017-10-31 Access Medical Systems, Ltd. Systems for immunoassay tests
EP2665833B1 (de) * 2011-01-17 2017-04-19 Life Technologies Corporation Arbeitsablauf zur nachweis von liganden mit nukleinsäuren
US10494671B2 (en) 2011-01-17 2019-12-03 Life Technologies Corporation Enzymatic ligation of nucleic acids
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
WO2014163886A1 (en) 2013-03-12 2014-10-09 President And Fellows Of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
EP4108782B1 (de) 2011-12-22 2023-06-07 President and Fellows of Harvard College Zusammensetzungen und verfahren zur analytdetektion
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
US9029086B2 (en) 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
KR20220038550A (ko) 2013-03-13 2022-03-28 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
IE86624B1 (en) 2013-05-21 2016-02-10 Src Inc Methods and systems for quantitative fluorescence-based detection of molecules and proteins
EP3603679B1 (de) 2013-06-04 2022-08-10 President and Fellows of Harvard College Rna-geführte transkriptionsregulation
US9879313B2 (en) 2013-06-25 2018-01-30 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US20160146804A1 (en) * 2013-06-27 2016-05-26 The Board Of Trustees Of The Leland Stanford Junior University Dna-conjugated antibodies for improved antibody affinity and reduced antibody cross reactivity
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
AU2015259048B2 (en) 2014-05-15 2021-09-09 Meso Scale Technologies, Llc. Improved assay methods
DE102014209393B4 (de) * 2014-05-19 2016-02-04 Trumpf Werkzeugmaschinen Gmbh + Co. Kg Verfahren zum maschinellen Bearbeiten eines plattenartigen Werkstücks, insbesondere einer Blechtafel
AU2015319825A1 (en) * 2014-09-26 2017-04-27 Nooma Bio, Inc. Target sequence detection by nanopore sensing of synthetic probes
EP4119677B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
EP3933047A1 (de) 2015-09-24 2022-01-05 AbVitro LLC Affinitätsoligonukleotidkonjugate und verwendungen davon
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
WO2017079406A1 (en) 2015-11-03 2017-05-11 President And Fellows Of Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
WO2017189525A1 (en) 2016-04-25 2017-11-02 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
WO2017205344A1 (en) * 2016-05-25 2017-11-30 Bio-Rad Laboratories, Inc. Digital proximity assay
US11352667B2 (en) 2016-06-21 2022-06-07 10X Genomics, Inc. Nucleic acid sequencing
EP3507385A4 (de) 2016-08-31 2020-04-29 President and Fellows of Harvard College Verfahren zur kombination der detektion von biomolekülen in einem einzigen test mit fluoreszenter in-situ-sequenzierung
GB2570412A (en) 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
AU2017332495A1 (en) 2016-09-24 2019-04-11 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
WO2018160397A1 (en) * 2017-03-01 2018-09-07 The Board Of Trustees Of The Leland Stanford Junior University Highly specific circular proximity ligation assay
GB201703625D0 (en) * 2017-03-07 2017-04-19 Quantumdx Group Ltd Aptamer based methods for protein detection
WO2019068880A1 (en) 2017-10-06 2019-04-11 Cartana Ab RNA MATRIX LIGATION
CN112236527A (zh) * 2018-04-03 2021-01-15 皇家学习促进学会/麦吉尔大学 通过连接共定位的夹心测定法
US20210255189A1 (en) 2018-06-15 2021-08-19 Olink Proteomics Ab Biomarker panel for ovarian cancer
WO2020028194A1 (en) 2018-07-30 2020-02-06 Readcoor, Inc. Methods and systems for sample processing or analysis
US20220025447A1 (en) 2018-12-10 2022-01-27 10X Genomics, Inc. Generating spatial arrays with gradients
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
JP7344973B2 (ja) 2019-03-01 2023-09-14 マーシー バイオアナリティクス， インコーポレイテッド 標的実体を検出するためのシステム、組成物、及び方法
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
SG11202111878RA (en) 2019-05-31 2021-11-29 10X Genomics Inc Method of detecting target nucleic acid molecules
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP3891300B1 (de) 2019-12-23 2023-03-29 10X Genomics, Inc. Verfahren zur räumlichen analyse mittels rna-template-ligation
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
WO2021191449A1 (en) 2020-03-27 2021-09-30 Olink Proteomics Ab Method for detecting analytes
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
EP4162074B1 (de) 2020-06-08 2024-04-24 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
EP4121555A1 (de) 2020-12-21 2023-01-25 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
CA3203106A1 (en) 2021-01-20 2022-07-28 Parag Mallick Systems and methods for biomolecule quantitation
EP4281775A1 (de) 2021-01-21 2023-11-29 Nautilus Subsidiary, Inc. Systeme und verfahren zur biomolekülherstellung
KR20230169143A (ko) 2021-03-11 2023-12-15 노틸러스 서브시디어리, 인크. 생체분자 보유를 위한 시스템 및 방법
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung
AU2022341171A1 (en) 2021-09-09 2024-02-22 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
CA3227592A1 (en) 2021-09-22 2023-03-30 Gregory KAPP Methods and systems for determining polypeptide interactions
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240094215A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4883867A (en) 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5449603A (en) 1989-10-24 1995-09-12 Stratagene Method for hybridizing nucleic acids using single-stranded nucleic acid binding protein
US5733523A (en) 1990-12-10 1998-03-31 Akzo Nobel N.V. Targeted delivery of a therapeutic entity using complementary oligonucleotides
WO1993006482A1 (en) 1991-09-16 1993-04-01 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
WO1993006121A1 (en) 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
EP0672177B1 (de) 1992-01-28 2006-07-19 President And Fellows of Harvard College Verfahren fur nuklein saure hibridisierung mit verwendung von einzelstrangige dna bindende proteine
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
CA2137558A1 (en) 1992-07-17 1994-02-03 Wayne A. Marasco Method of intracellular binding of target molecules
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5410030A (en) 1993-04-05 1995-04-25 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes containing pyridinium moieties
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5436134A (en) 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5440016A (en) 1993-06-18 1995-08-08 Torrey Pines Institute For Molecular Studies Peptides of the formula (KFmoc) ZZZ and their uses
US5851829A (en) 1993-07-16 1998-12-22 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US5688997A (en) 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5688696A (en) 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
US5565974A (en) * 1995-03-31 1996-10-15 Xerox Corporation Penta-level xerographic unit
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
ATE214396T1 (de) 1995-06-21 2002-03-15 Martek Biosciences Corp Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung
US5731423A (en) 1996-03-21 1998-03-24 Transcell Technologies, Inc. Process for preparing sulfoxides
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
DE69818458T3 (de) 1997-05-28 2009-12-17 Crescendo Biologics Ltd., Babraham Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
DE69838210T2 (de) 1997-12-15 2008-05-15 Csl Behring Gmbh Markierter Primer, geeignet für die Detektion von Nukleinsäuren
EP1985714B1 (de) 1998-03-25 2012-02-29 Olink AB Zwei Affinitätsproben und Rolling-Circle-Replikation zur Detektion eines Zielmoleküls verwendende Verfahren und Kit
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
SE516272C2 (sv) 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
EP1249500A1 (de) 2001-04-12 2002-10-16 chimera biotec GmbH Verfahren zum Nachweis einer Substanz
AU2002353713A1 (en) 2001-11-23 2003-06-10 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
US7914987B2 (en) * 2004-06-14 2011-03-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
WO2007044903A2 (en) 2005-10-11 2007-04-19 Stratagene California Binary signal detection assays
US9291627B2 (en) 2007-07-17 2016-03-22 Agilent Technologies Inc. Analyte detection assays

Also Published As

Publication number Publication date
GB0605584D0 (en) 2006-04-26
EP1996941B1 (de) 2010-02-03
DE602007004666D1 (de) 2010-03-25
JP2009529904A (ja) 2009-08-27
EP1996941A1 (de) 2008-12-03
US8268554B2 (en) 2012-09-18
US20100021890A1 (en) 2010-01-28
JP5144639B2 (ja) 2013-02-13
WO2007107743A1 (en) 2007-09-27

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