GB1597912A - 1,phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-dione derivatives - Google Patents
1,phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-dione derivatives Download PDFInfo
- Publication number
- GB1597912A GB1597912A GB20952/80A GB2095280A GB1597912A GB 1597912 A GB1597912 A GB 1597912A GB 20952/80 A GB20952/80 A GB 20952/80A GB 2095280 A GB2095280 A GB 2095280A GB 1597912 A GB1597912 A GB 1597912A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- compounds according
- carbons
- compounds
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- -1 chloro, bromo, iodo Chemical group 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 2
- 125000001589 carboacyl group Chemical group 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- YGLDQFWPUCURIP-UHFFFAOYSA-N 3h-3-benzazepine Chemical compound C1=CNC=CC2=CC=CC=C21 YGLDQFWPUCURIP-UHFFFAOYSA-N 0.000 description 1
- MEXPXLPUVFBQGJ-UHFFFAOYSA-N 5-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1NCCC2=CC=CC=C2C1C1=CC=CC=C1 MEXPXLPUVFBQGJ-UHFFFAOYSA-N 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 229940005501 dopaminergic agent Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76050077A | 1977-01-19 | 1977-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1597912A true GB1597912A (en) | 1981-09-16 |
Family
ID=25059291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20952/80A Expired GB1597912A (en) | 1977-01-19 | 1978-01-10 | 1,phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-dione derivatives |
| GB953/78A Expired GB1597911A (en) | 1977-01-19 | 1978-01-10 | Benzazepines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB953/78A Expired GB1597911A (en) | 1977-01-19 | 1978-01-10 | Benzazepines |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS6040423B2 (enExample) |
| AU (1) | AU510459B2 (enExample) |
| BE (1) | BE862878A (enExample) |
| CA (1) | CA1090334A (enExample) |
| CH (2) | CH642634A5 (enExample) |
| DE (1) | DE2802086A1 (enExample) |
| DK (1) | DK19978A (enExample) |
| FR (2) | FR2378017A1 (enExample) |
| GB (2) | GB1597912A (enExample) |
| HU (1) | HU175836B (enExample) |
| IE (1) | IE46761B1 (enExample) |
| LU (1) | LU78873A1 (enExample) |
| NL (1) | NL7800637A (enExample) |
| SE (1) | SE437265B (enExample) |
| ZA (1) | ZA777444B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5481290A (en) * | 1977-11-17 | 1979-06-28 | Smithkline Corp | Benzazepin compound |
| US4171359A (en) * | 1978-04-12 | 1979-10-16 | Smithkline Corporation | Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4251525A (en) * | 1979-05-25 | 1981-02-17 | Smithkline Corporation | 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
| DE3065940D1 (en) * | 1979-07-10 | 1984-01-26 | Smithkline Beckman Corp | Synergistic antihypertensive compositions |
| CN1823059A (zh) * | 2003-05-22 | 2006-08-23 | 先灵公司 | 作为治疗肥胖和CNS疾病的选择性D<sub>1</sub>/D<sub>5</sub>受体拮抗剂的5－H－苯并[D]萘并[2,1－B]氮杂䓬衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH555831A (de) * | 1967-02-17 | 1974-11-15 | Scherico Ltd | Verfahren zur herstellung von neuen benzazepinen. |
| US3609139A (en) * | 1969-04-01 | 1971-09-28 | Sandoz Ag | Substituted dibenzdiazonines |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
| GB1561305A (en) * | 1975-07-02 | 1980-02-20 | Smithkline Corp | Benzazepine derivatives and pharmeceutical compositions containing them |
-
1977
- 1977-12-14 ZA ZA00777444A patent/ZA777444B/xx unknown
-
1978
- 1978-01-10 GB GB20952/80A patent/GB1597912A/en not_active Expired
- 1978-01-10 GB GB953/78A patent/GB1597911A/en not_active Expired
- 1978-01-13 FR FR7800998A patent/FR2378017A1/fr active Granted
- 1978-01-13 BE BE184290A patent/BE862878A/xx not_active IP Right Cessation
- 1978-01-16 AU AU32465/78A patent/AU510459B2/en not_active Expired
- 1978-01-16 LU LU78873A patent/LU78873A1/xx unknown
- 1978-01-16 SE SE7800455A patent/SE437265B/sv not_active IP Right Cessation
- 1978-01-16 DK DK19978A patent/DK19978A/da not_active Application Discontinuation
- 1978-01-16 CA CA294,973A patent/CA1090334A/en not_active Expired
- 1978-01-18 NL NL7800637A patent/NL7800637A/xx not_active Application Discontinuation
- 1978-01-18 JP JP53004769A patent/JPS6040423B2/ja not_active Expired
- 1978-01-18 DE DE19782802086 patent/DE2802086A1/de not_active Withdrawn
- 1978-01-18 IE IE111/78A patent/IE46761B1/en unknown
- 1978-01-18 HU HU78SI1612A patent/HU175836B/hu unknown
- 1978-01-18 CH CH52578A patent/CH642634A5/de not_active IP Right Cessation
- 1978-06-02 FR FR7816583A patent/FR2384759A1/fr active Granted
-
1982
- 1982-06-09 CH CH357382A patent/CH640228A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7800637A (nl) | 1978-07-21 |
| FR2378017B1 (enExample) | 1981-07-10 |
| SE7800455L (sv) | 1978-07-20 |
| AU510459B2 (en) | 1980-06-26 |
| BE862878A (fr) | 1978-07-13 |
| CH642634A5 (en) | 1984-04-30 |
| GB1597911A (en) | 1981-09-16 |
| JPS5390281A (en) | 1978-08-08 |
| DK19978A (da) | 1978-07-20 |
| JPS6040423B2 (ja) | 1985-09-11 |
| CA1090334A (en) | 1980-11-25 |
| IE780111L (en) | 1978-07-19 |
| SE437265B (sv) | 1985-02-18 |
| FR2384759A1 (fr) | 1978-10-20 |
| LU78873A1 (fr) | 1978-06-09 |
| AU3246578A (en) | 1979-07-26 |
| DE2802086A1 (de) | 1978-07-20 |
| HU175836B (hu) | 1980-10-28 |
| FR2384759B1 (enExample) | 1980-07-18 |
| IE46761B1 (en) | 1983-09-21 |
| CH640228A5 (en) | 1983-12-30 |
| ZA777444B (en) | 1978-10-25 |
| FR2378017A1 (fr) | 1978-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI65238C (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar | |
| CA2204748A1 (en) | Use of dioxomorpholines for combating endoparasites, new dioxomorpholines and processes for their preparation | |
| Marino et al. | Regioselective reactions of organocuprates with cycloalkene epoxides | |
| IE820480L (en) | Platinum diamine complexes. | |
| GB1597912A (en) | 1,phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-dione derivatives | |
| JPS5721388A (en) | Condensed pyrazole derivative | |
| YU46675B (sh) | Postupak za dobijanje derivata 1-(hidrok-sistirol)-5h- 2,3-benzodiazepina | |
| Tomson et al. | Some 2-and 4-substituted estrone 3-methyl ethers | |
| MY118605A (en) | Process for the preparation of a thiazolidinedione derivative | |
| Tseng et al. | Synthesis of 2-Pyrrolidinones by The Cyclization of N-Allylhaloacetamides | |
| DE3220257C2 (de) | Photochrome Spiro [1,8 a-tetrahydroindolizine], Verfahren zur Herstellung und ihre Verwendung in strahlungsempfindlichen Materialien | |
| Wineholt et al. | Heterocyclic Studies. XXI. 1, 2, 3, 7-Tetrahydro-1-acyl-7-methoxy-5-methyl-6-phenyl-4H-1, 2-diazepin-4-ones1, 2 | |
| GB9224648D0 (en) | Polycyclic dyes | |
| HUT68258A (en) | Fungicidal composition containing pyrimidinyl acrylic acid derivatives and process for their preparation | |
| ES453544A1 (es) | Un procedimiento para la preparacion de derivados de etila- mina. | |
| CA1048024A (en) | Triazino (4,3-d) (1,4) benzodiazepine-3,4,7-triones | |
| DE3161004D1 (en) | Derivates of 3-formyl-4-methylpentanoic acid, their preparation and their use in the preparation of substituted 3-formyl-but-3-en-1-oic acid | |
| CA2302381A1 (en) | Process for producing 3,4-dihydroxy-3-cyclobutene-1,2-dione | |
| US3311626A (en) | Cyclopentaquinoxaline derivatives | |
| GB1589752A (en) | 5,6-dihydro-3-phenyl-imidazo(5,1-a)isoquinolines | |
| GB1566528A (en) | Process for producing indoline derivatives | |
| Ziffer et al. | Photodimers of piperitone | |
| Dennis et al. | 1, 3-Dipolar character of six-membered aromatic rings. Part XI. 1-Oxido-3-phenylphthalazinium | |
| Takai et al. | Reaction of Tantalum-Alkyne Complexes with Isocyanates Leading to (E)-. ALPHA.,. BETA.-Unsaturated Amides. Stereoselective Functionalization of Carbon-Carbon Triple Bonds. | |
| US5739337A (en) | Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |