GB1573322A - Phenylactic acid ester derivatives - Google Patents

Phenylactic acid ester derivatives Download PDF

Info

Publication number
GB1573322A
GB1573322A GB51350/76A GB5135076A GB1573322A GB 1573322 A GB1573322 A GB 1573322A GB 51350/76 A GB51350/76 A GB 51350/76A GB 5135076 A GB5135076 A GB 5135076A GB 1573322 A GB1573322 A GB 1573322A
Authority
GB
United Kingdom
Prior art keywords
compound
mixture
mmhg
acid
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB51350/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of GB1573322A publication Critical patent/GB1573322A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB51350/76A 1975-12-24 1976-12-24 Phenylactic acid ester derivatives Expired GB1573322A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50156799A JPS5826744B2 (ja) 1975-12-24 1975-12-24 シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Publications (1)

Publication Number Publication Date
GB1573322A true GB1573322A (en) 1980-08-20

Family

ID=15635562

Family Applications (1)

Application Number Title Priority Date Filing Date
GB51350/76A Expired GB1573322A (en) 1975-12-24 1976-12-24 Phenylactic acid ester derivatives

Country Status (9)

Country Link
JP (1) JPS5826744B2 (fr)
AU (1) AU507661B2 (fr)
CA (1) CA1076134A (fr)
CH (1) CH617919A5 (fr)
DE (1) DE2658610C2 (fr)
FR (1) FR2336126A1 (fr)
GB (1) GB1573322A (fr)
NL (1) NL180381C (fr)
SE (1) SE433492B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242000B1 (en) 1991-05-13 2001-06-05 The Boots Company Plc Composition of S−sodium ibuprofen
EP2054384A4 (fr) * 2006-08-15 2010-11-03 Techfields Biochem Co Ltd Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée
CN103948571A (zh) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药
CN109134261A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
CN109134262A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5517358A (en) * 1978-07-24 1980-02-06 Teikoku Seiyaku Kk Butyl propionate derivative, its preparation, and antiphlogistic and analgesic comprising it
JPS54144336A (en) * 1978-07-24 1979-11-10 Teikoku Seiyaku Kk Propionic acid propylester derivative*its manufacture and antiiinflammatory and sedative agent containing it
JPS5587770A (en) * 1978-12-27 1980-07-02 Hisamitsu Pharmaceut Co Inc Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
DE3225290A1 (de) * 1982-07-07 1984-01-12 Merck Patent Gmbh Ringverbindungen
YU43408B (en) * 1985-04-26 1989-06-30 Lek Tovarna Farmacevtskih Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
JPH0635378B2 (ja) * 1985-06-27 1994-05-11 ポ−ラ化成工業株式会社 化粧料
ES2004447A6 (es) * 1987-07-06 1989-01-01 Sune Coma Nuria Procedimiento de obtencion de un nuevo ester del acido 2-(p-isobutilfeni)-propionico
DE3811118C1 (fr) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
IT1217589B (it) * 1988-05-13 1990-03-30 Pulitzer Italiana Agente antiinfiammatorio per la terapia dell'ipertrofia prostatica,sua preparazione e relative composizioni farmaceutiche
JPH0639449B2 (ja) * 1989-04-10 1994-05-25 エーザイ株式会社 ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
KR20190091378A (ko) 2007-06-04 2019-08-05 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
US9809557B2 (en) 2011-10-31 2017-11-07 Claus Selch Larsen Prodrugs of non-steroid anti-inflammatory agents (NSAIDS)
US9759472B2 (en) 2012-12-13 2017-09-12 Whirlpool Corporation Clear ice maker with warm air flow
US9557087B2 (en) 2012-12-13 2017-01-31 Whirlpool Corporation Clear ice making apparatus having an oscillation frequency and angle
US9500398B2 (en) 2012-12-13 2016-11-22 Whirlpool Corporation Twist harvest ice geometry
US9470448B2 (en) 2012-12-13 2016-10-18 Whirlpool Corporation Apparatus to warm plastic side of mold
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用
EP3209953B1 (fr) 2014-10-23 2020-03-25 Whirlpool Corporation Procédé et appareil permettant d'augmenter la vitesse de production de glace dans une machine à glaçons automatique
JP6153264B2 (ja) * 2015-01-05 2017-06-28 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
US10907874B2 (en) 2018-10-22 2021-02-02 Whirlpool Corporation Ice maker downspout

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242000B1 (en) 1991-05-13 2001-06-05 The Boots Company Plc Composition of S−sodium ibuprofen
US6525214B1 (en) 1991-05-13 2003-02-25 Bernard John Armitage Therapeutic agent
CN103948571A (zh) * 2006-07-18 2014-07-30 天津昕晨泰飞尔医药科技有限公司 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药
EP2054384A4 (fr) * 2006-08-15 2010-11-03 Techfields Biochem Co Ltd Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée
CN109134261A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物
CN109134262A (zh) * 2017-06-15 2019-01-04 北京蓝丹医药科技有限公司 一种洛索洛芬衍生物

Also Published As

Publication number Publication date
FR2336126A1 (fr) 1977-07-22
AU507661B2 (en) 1980-02-21
FR2336126B1 (fr) 1979-03-09
CH617919A5 (en) 1980-06-30
NL7614308A (nl) 1977-06-28
NL180381C (nl) 1987-02-16
NL180381B (nl) 1986-09-16
AU2087876A (en) 1978-06-29
SE7613651L (sv) 1977-06-25
CA1076134A (fr) 1980-04-22
JPS5826744B2 (ja) 1983-06-04
JPS5278848A (en) 1977-07-02
DE2658610C2 (de) 1982-12-23
DE2658610A1 (de) 1977-07-07
SE433492B (sv) 1984-05-28

Similar Documents

Publication Publication Date Title
GB1573322A (en) Phenylactic acid ester derivatives
US4150137A (en) Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
DE2740588A1 (de) Imidazo- eckige klammer auf 1,2-a eckige klammer zu -chinolin-2-carbon- saeuren und deren derivate sowie pharmazeutische zubereitungen, die diese verbindungen enthalten
EP0211363A2 (fr) Dérivés de 3-phénylthiométhylstyrène, procédé pour leur préparation et des agents antiallergiques et agent inhibitant la tyrosinekinase les contenant
EP0116360B1 (fr) Composé de 1-phényl-2-aminocarbonylindole, leur préparation et les médicaments les contenant
DE3035086C2 (fr)
EP0185909A1 (fr) Composés de 5-alkyl-1-phényl-2-pipérazinoalkylpyrazolin-3-one ainsi que procédés et produits intermédiaires pour leur préparation et médicaments comprenant ces composés
DE2360545A1 (de) Neue trialkoxyaroyldiamine
HU184193B (en) Process for preparing /s/-alpha-cyano-3-phenoxy-benzyl-alcohol ester with insecticide activity formed with d-2-isopropyl-2-/4-chloro-phenyl/-acetic acid
US4515944A (en) 1,5-Diphenyl-2-haloalkylpyrazolin-3-one intermediates
DE2225190C3 (de) Neue Acetophenonoximderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4152457A (en) Tropone derivatives
US4208420A (en) New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications
US4125625A (en) Troponyl-oxamic acid derivatives
US4362891A (en) Alkanoic acid derivatives
CROWE et al. STUDIES ON THE CHEMISTRY OF HETEROCYCLICS. XI. FURTHER REACTIONS OF THENALDEHYDES.
US4461912A (en) Phenylacetic acid derivatives, their preparation and compositions containing them
US4060638A (en) Anthranilic acid amides
US3510495A (en) Novel substituted 1-amino-2-pyrrolidinones
US4335251A (en) Phenyl-i-propionic acid esters and pharmaceutical use thereof
Kinstle et al. Acenaphthylene oxide
Johnson et al. 2-(3-Aryl-5-pyrazolyl) benzoic acid chemistry
US4172145A (en) Benzo(b)furylacetic acid derivatives to reduce inflammation
US3755442A (en) Acenaphthyl amides and amines
US4166125A (en) 2-oxo-phenylbutanoic acid derivatives

Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19961223