GB1530201A - Process for the preparation of aminoglycoside antibiotics and intermediates therefor - Google Patents

Process for the preparation of aminoglycoside antibiotics and intermediates therefor

Info

Publication number
GB1530201A
GB1530201A GB15421/76A GB1542176A GB1530201A GB 1530201 A GB1530201 A GB 1530201A GB 15421/76 A GB15421/76 A GB 15421/76A GB 1542176 A GB1542176 A GB 1542176A GB 1530201 A GB1530201 A GB 1530201A
Authority
GB
United Kingdom
Prior art keywords
group
groups
formula
preparation
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15421/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER Ltd
Original Assignee
PFIZER Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER Ltd filed Critical PFIZER Ltd
Priority to GB15421/76A priority Critical patent/GB1530201A/en
Priority to IL51775A priority patent/IL51775A/xx
Priority to AU23721/77A priority patent/AU497416B2/en
Priority to ZA00771944A priority patent/ZA771944B/xx
Priority to NZ189175A priority patent/NZ189175A/xx
Priority to NZ183733A priority patent/NZ183733A/xx
Priority to NL7703567A priority patent/NL7703567A/xx
Priority to PH19649A priority patent/PH14029A/en
Priority to GR53193A priority patent/GR68936B/el
Priority to FI771144A priority patent/FI771144A7/fi
Priority to PT66422A priority patent/PT66422B/pt
Priority to RO7790001A priority patent/RO74431A/ro
Priority to LU77108A priority patent/LU77108A1/xx
Priority to RO77101733A priority patent/RO79969A/ro
Priority to FR7711108A priority patent/FR2348223A1/fr
Priority to AR267190A priority patent/AR219074A1/es
Priority to CA276,055A priority patent/CA1083568A/en
Priority to IE761/77A priority patent/IE45030B1/en
Priority to JP4246577A priority patent/JPS52139044A/ja
Priority to PL1977215139A priority patent/PL112867B1/pl
Priority to BE176696A priority patent/BE853564A/xx
Priority to PL19737277A priority patent/PL197372A1/xx
Priority to CH457377A priority patent/CH622528A5/fr
Priority to EG217/77A priority patent/EG12909A/xx
Priority to DK164277A priority patent/DK164277A/da
Priority to ES457793A priority patent/ES457793A1/es
Priority to BG036000A priority patent/BG27759A3/xx
Priority to BG037121A priority patent/BG28072A4/xx
Priority to DD77204695A priority patent/DD135496A5/xx
Priority to AT261477A priority patent/AT356267B/de
Priority to DD7700198399A priority patent/DD130661A5/xx
Priority to DE2716533A priority patent/DE2716533C3/de
Priority to CS772453A priority patent/CS202570B2/cs
Priority to JP7490277A priority patent/JPS535141A/ja
Priority to US05/851,400 priority patent/US4160082A/en
Priority to CS78731A priority patent/CS202571B2/cs
Priority to AT451678A priority patent/AT356273B/de
Publication of GB1530201A publication Critical patent/GB1530201A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB15421/76A 1976-04-14 1976-04-14 Process for the preparation of aminoglycoside antibiotics and intermediates therefor Expired GB1530201A (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
GB15421/76A GB1530201A (en) 1976-04-14 1976-04-14 Process for the preparation of aminoglycoside antibiotics and intermediates therefor
IL51775A IL51775A (en) 1976-04-14 1977-03-29 Process and novel intermediates for the preparation of 1-n-substituted kanamycin derivatives
AU23721/77A AU497416B2 (en) 1976-04-14 1977-03-29 Preparation of amino glcoside antibiotics and intermediates
ZA00771944A ZA771944B (en) 1976-04-14 1977-03-30 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor
NZ189175A NZ189175A (en) 1976-04-14 1977-03-30 Intermediates for 1-n-substituted kanamycin derivatives
NZ183733A NZ183733A (en) 1976-04-14 1977-03-30 Preparation of 1-n-substituted-kanamycins
NL7703567A NL7703567A (nl) 1976-04-14 1977-04-01 Werkwijze voor het bereiden van aminoglycoside antibiotica.
PH19649A PH14029A (en) 1976-04-14 1977-04-12 Process for the preparation of aminoglycoside antibiotics
GR53193A GR68936B (enrdf_load_stackoverflow) 1976-04-14 1977-04-12
FI771144A FI771144A7 (enrdf_load_stackoverflow) 1976-04-14 1977-04-12
PT66422A PT66422B (en) 1976-04-14 1977-04-12 Process for the preparation of aminoglycoside antibiotics
RO7790001A RO74431A (ro) 1976-04-14 1977-04-12 Procedeu pentru prepararea unor derivati ai kanamicinei 1-n-substituite
LU77108A LU77108A1 (enrdf_load_stackoverflow) 1976-04-14 1977-04-12
RO77101733A RO79969A (ro) 1976-04-14 1977-04-12 Procedeu pentru prepararea unor derivati ai kanamicinei
FR7711108A FR2348223A1 (fr) 1976-04-14 1977-04-13 Procede de preparation d'antibiotiques aminoglycosidiques
AR267190A AR219074A1 (es) 1976-04-14 1977-04-13 Procedimiento para la preparacion de derivados de 1-n-(4-amino-2-hidroxibutil)-kanamicina,compuestos utilizados exclusivamente como materia prima para la preparacion de dichos derivados,y procedimiento para preparar tales compuestos
CA276,055A CA1083568A (en) 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor
IE761/77A IE45030B1 (en) 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor
JP4246577A JPS52139044A (en) 1976-04-14 1977-04-13 Process for manufacture of aminoglycoside series antibiotics and new intermediates thereof and process for manufacture thereof
PL1977215139A PL112867B1 (en) 1976-04-14 1977-04-13 Process for preparing novel derivatives of kanamycin
BE176696A BE853564A (fr) 1976-04-14 1977-04-13 Procede de preparation d'antibiotiques aminoglycosidiques
PL19737277A PL197372A1 (pl) 1976-04-14 1977-04-13 Sposob wytwarzania pochodnych kanamycyny
CH457377A CH622528A5 (en) 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics
EG217/77A EG12909A (en) 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor
DK164277A DK164277A (da) 1976-04-14 1977-04-13 Fremgangsmade til fremstilling af aminoglycosidantibiotika
ES457793A ES457793A1 (es) 1976-04-14 1977-04-14 Procedimiento para preparar derivados 1-n-sustituidos de ca-namicina.
BG036000A BG27759A3 (bg) 1976-04-14 1977-04-14 Метод за получаване на аминогликозидни антибиотици
BG037121A BG28072A4 (bg) 1976-04-14 1977-04-14 Метод за получаване на 1 n заместени канамицинови производни
DD77204695A DD135496A5 (de) 1976-04-14 1977-04-14 Verfahren zur herstellung von zwischenprodukten fuer aminoglycoside antibiotica
AT261477A AT356267B (de) 1976-04-14 1977-04-14 Verfahren zur herstellung von amino- glykosidverbindungen
DD7700198399A DD130661A5 (de) 1976-04-14 1977-04-14 Verfahren zur herstellung von aminoglycosid-antibiotica
DE2716533A DE2716533C3 (de) 1976-04-14 1977-04-14 N-Acetylierte oder -halogenacetylierte Kanamycine A und B, Verfahren zu ihrer Herstellung und ihre Verwendung
CS772453A CS202570B2 (en) 1976-04-14 1977-04-14 Process for preparing aminoglycsidic antibiotics
JP7490277A JPS535141A (en) 1976-04-14 1977-06-23 New intermediates of aminoglycoside and process for manufacture thereof
US05/851,400 US4160082A (en) 1976-04-14 1977-11-14 Intermediates for aminoglycoside antibiotics
CS78731A CS202571B2 (cs) 1976-04-14 1978-02-03 Způsob výroby selektivně chráněného derivátu kanamycinu A nebo kanamycinu B
AT451678A AT356273B (de) 1976-04-14 1978-06-21 Verfahren zur herstellung von neuen geschuetzten kanamycinverbindungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15421/76A GB1530201A (en) 1976-04-14 1976-04-14 Process for the preparation of aminoglycoside antibiotics and intermediates therefor

Publications (1)

Publication Number Publication Date
GB1530201A true GB1530201A (en) 1978-10-25

Family

ID=10058845

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15421/76A Expired GB1530201A (en) 1976-04-14 1976-04-14 Process for the preparation of aminoglycoside antibiotics and intermediates therefor

Country Status (28)

Country Link
JP (2) JPS52139044A (enrdf_load_stackoverflow)
AR (1) AR219074A1 (enrdf_load_stackoverflow)
AT (1) AT356267B (enrdf_load_stackoverflow)
AU (1) AU497416B2 (enrdf_load_stackoverflow)
BE (1) BE853564A (enrdf_load_stackoverflow)
BG (2) BG27759A3 (enrdf_load_stackoverflow)
CA (1) CA1083568A (enrdf_load_stackoverflow)
CH (1) CH622528A5 (enrdf_load_stackoverflow)
CS (1) CS202570B2 (enrdf_load_stackoverflow)
DD (2) DD130661A5 (enrdf_load_stackoverflow)
DE (1) DE2716533C3 (enrdf_load_stackoverflow)
DK (1) DK164277A (enrdf_load_stackoverflow)
EG (1) EG12909A (enrdf_load_stackoverflow)
ES (1) ES457793A1 (enrdf_load_stackoverflow)
FI (1) FI771144A7 (enrdf_load_stackoverflow)
FR (1) FR2348223A1 (enrdf_load_stackoverflow)
GB (1) GB1530201A (enrdf_load_stackoverflow)
GR (1) GR68936B (enrdf_load_stackoverflow)
IE (1) IE45030B1 (enrdf_load_stackoverflow)
IL (1) IL51775A (enrdf_load_stackoverflow)
LU (1) LU77108A1 (enrdf_load_stackoverflow)
NL (1) NL7703567A (enrdf_load_stackoverflow)
NZ (1) NZ183733A (enrdf_load_stackoverflow)
PH (1) PH14029A (enrdf_load_stackoverflow)
PL (2) PL197372A1 (enrdf_load_stackoverflow)
PT (1) PT66422B (enrdf_load_stackoverflow)
RO (2) RO74431A (enrdf_load_stackoverflow)
ZA (1) ZA771944B (enrdf_load_stackoverflow)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
JPS61191642U (enrdf_load_stackoverflow) * 1985-05-20 1986-11-28
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
CN101481397B (zh) * 2009-01-23 2012-10-31 北京大学 一种新的卡那霉素a衍生物及其制备方法和用途
MY163275A (en) 2010-11-04 2017-08-30 Albireo Ab Ibat inhibitors for the treatment of liver diseases
WO2015199146A1 (ja) 2014-06-25 2015-12-30 味の素株式会社 固形製剤及びその安定化方法
CA2952406A1 (en) 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for preventing or reducing coloration thereof
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof

Also Published As

Publication number Publication date
ES457793A1 (es) 1978-08-01
DE2716533B2 (de) 1981-04-30
BG28072A4 (bg) 1980-02-25
NZ183733A (en) 1979-12-11
RO79969B (ro) 1983-01-30
PT66422B (en) 1978-09-18
CA1083568A (en) 1980-08-12
DE2716533A1 (de) 1977-11-03
LU77108A1 (enrdf_load_stackoverflow) 1979-01-18
GR68936B (enrdf_load_stackoverflow) 1982-03-29
FI771144A7 (enrdf_load_stackoverflow) 1977-10-15
NL7703567A (nl) 1977-10-18
IE45030B1 (en) 1982-06-02
RO74431A (ro) 1981-08-30
AR219074A1 (es) 1980-07-31
JPS52139044A (en) 1977-11-19
AU2372177A (en) 1978-10-05
DD130661A5 (de) 1978-04-19
CS202570B2 (en) 1981-01-30
AT356267B (de) 1980-04-25
IL51775A0 (en) 1977-05-31
PT66422A (en) 1977-05-01
PL197372A1 (pl) 1979-06-18
BE853564A (fr) 1977-10-13
ZA771944B (en) 1978-03-29
ATA261477A (de) 1979-09-15
IL51775A (en) 1980-07-31
IE45030L (en) 1977-10-14
EG12909A (en) 1979-12-31
CH622528A5 (en) 1981-04-15
JPS5421326B2 (enrdf_load_stackoverflow) 1979-07-30
DD135496A5 (de) 1979-05-09
DK164277A (da) 1977-10-15
JPS535141A (en) 1978-01-18
BG27759A3 (bg) 1979-12-12
DE2716533C3 (de) 1982-05-13
PH14029A (en) 1980-12-12
PL112867B1 (en) 1980-11-29
JPS5549587B2 (enrdf_load_stackoverflow) 1980-12-12
FR2348223A1 (fr) 1977-11-10
RO79969A (ro) 1983-02-01
AU497416B2 (en) 1978-12-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee