GB1510571A - Aminoglycosidic antibiotic - Google Patents
Aminoglycosidic antibioticInfo
- Publication number
- GB1510571A GB1510571A GB10045/76A GB1004576A GB1510571A GB 1510571 A GB1510571 A GB 1510571A GB 10045/76 A GB10045/76 A GB 10045/76A GB 1004576 A GB1004576 A GB 1004576A GB 1510571 A GB1510571 A GB 1510571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- nrrl
- acid addition
- streptomyces
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 6
- 239000002253 acid Substances 0.000 abstract 3
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 abstract 2
- 241000187747 Streptomyces Species 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 241000220254 Streptomyces coeruleorubidus Species 0.000 abstract 1
- IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salts Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229960002319 barbital Drugs 0.000 abstract 1
- 229960003874 butobarbital Drugs 0.000 abstract 1
- STDBAQMTJLUMFW-UHFFFAOYSA-N butobarbital Chemical compound CCCCC1(CC)C(=O)NC(=O)NC1=O STDBAQMTJLUMFW-UHFFFAOYSA-N 0.000 abstract 1
- 229930188550 carminomycin Natural products 0.000 abstract 1
- XREUEWVEMYWFFA-CSKJXFQVSA-N carminomycin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XREUEWVEMYWFFA-CSKJXFQVSA-N 0.000 abstract 1
- XREUEWVEMYWFFA-UHFFFAOYSA-N carminomycin I Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XREUEWVEMYWFFA-UHFFFAOYSA-N 0.000 abstract 1
- 229950001725 carubicin Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 229960002695 phenobarbital Drugs 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001544 sulfathiazole Drugs 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7507893A FR2303552A1 (fr) | 1975-03-13 | 1975-03-13 | Nouveau derive du naphtacene, sa preparation et les compositions qui le contiennent |
| FR7520604A FR2315941A2 (fr) | 1975-07-01 | 1975-07-01 | Nouveau derive du naphtagene, sa preparation et les compositions qui le contiennent |
| FR7602912A FR2340096A2 (fr) | 1976-02-03 | 1976-02-03 | Nouveau derive du naphtacene, sa preparation et les compositions qui le contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1510571A true GB1510571A (en) | 1978-05-10 |
Family
ID=27250421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10045/76A Expired GB1510571A (en) | 1975-03-13 | 1976-03-12 | Aminoglycosidic antibiotic |
Country Status (13)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096958A (en) * | 1976-03-04 | 1978-06-27 | Stobb, Inc. | Method for handling bundles of sheets |
| IT1155446B (it) * | 1982-12-23 | 1987-01-28 | Erba Farmitalia | Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine |
| JP2779652B2 (ja) * | 1988-12-27 | 1998-07-23 | 武田薬品工業株式会社 | 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物 |
-
1976
- 1976-03-05 NL NL7602342A patent/NL7602342A/xx not_active Application Discontinuation
- 1976-03-11 AU AU11900/76A patent/AU1190076A/en not_active Expired
- 1976-03-11 IL IL49197A patent/IL49197A0/xx unknown
- 1976-03-12 JP JP51027038A patent/JPS51115992A/ja active Pending
- 1976-03-12 CA CA248,335A patent/CA1068225A/fr not_active Expired
- 1976-03-12 LU LU74541A patent/LU74541A1/xx unknown
- 1976-03-12 NZ NZ180300A patent/NZ180300A/xx unknown
- 1976-03-12 NO NO760873A patent/NO760873L/no unknown
- 1976-03-12 FI FI760645A patent/FI760645A7/fi not_active Application Discontinuation
- 1976-03-12 HU HU76RO883A patent/HU175158B/hu unknown
- 1976-03-12 DK DK110176A patent/DK110176A/da unknown
- 1976-03-12 DE DE19762610557 patent/DE2610557A1/de not_active Withdrawn
- 1976-03-12 GB GB10045/76A patent/GB1510571A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL49197A0 (en) | 1976-05-31 |
| HU175158B (hu) | 1980-05-28 |
| LU74541A1 (enrdf_load_stackoverflow) | 1977-01-11 |
| FI760645A7 (enrdf_load_stackoverflow) | 1976-09-14 |
| NZ180300A (en) | 1978-07-28 |
| AU1190076A (en) | 1977-09-15 |
| NL7602342A (nl) | 1976-09-15 |
| DE2610557A1 (de) | 1976-09-23 |
| NO760873L (enrdf_load_stackoverflow) | 1976-09-14 |
| DK110176A (da) | 1976-09-14 |
| CA1068225A (fr) | 1979-12-18 |
| JPS51115992A (en) | 1976-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |