GB1510571A - Aminoglycosidic antibiotic - Google Patents
Aminoglycosidic antibioticInfo
- Publication number
- GB1510571A GB1510571A GB10045/76A GB1004576A GB1510571A GB 1510571 A GB1510571 A GB 1510571A GB 10045/76 A GB10045/76 A GB 10045/76A GB 1004576 A GB1004576 A GB 1004576A GB 1510571 A GB1510571 A GB 1510571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- nrrl
- acid addition
- streptomyces
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1510571 Antibiotic 32,999 RP RHONE POULENC INDUSTRIES 12 March 1976 13 March 1975 1 July 1975 3 Feb 1976] 10045/76 Heading C2C Novel antibiotic 32,999 RP of the formula and acid addition salts thereof, are prepared (a) by microbiological reduction of carminomycin of the formula or an acid addition salt thereof, (b) by aerobically cultivating Streptomyces coeruleorubidus DS 8,899(NRRL 3046), DS 31,723(NRRL 3045) or DS7,126 (NRRL 8098) or Streptomyces bifurcus DS23,219 (NRRL 3539) or a mutant thereof capable of producing the antibiotic, in an aqueous nutrient medium containing assimilable sources of C,N and inorganic substances, and an adjuvant selected from barbital, phenobarbital, butobarbital, penthiobarbital and alkali metal salts of said barbitals, amethopterin, sulphanilamide, sulphathiazole and sulphapyridazine, and isolating the desired product from the medium ; and (c) by aerobically cultivating Streptomyces atroviolaceus DS 8,938 (NRRL 8148) or a mutant thereof capable of producing the antibiotic, using an aqueous nutrient medium containing assimilable sources of C, N and inorganic substances, and isolating the desired product from the medium hydrolysis. Pharmaceutical compositions having antitumour activity comprise, as active ingredient, antibiotic 32,999RP or a non-toxic acid addition salt thereof, in association with a pharmaceutically acceptable carrier. 32,999RP may be converted to its aglycone by acid hydrolysis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7507893A FR2303552A1 (en) | 1975-03-13 | 1975-03-13 | Antitumour naphthacene deriv - prepd. by redn. of carminomycin or culture of Streptomyces microorganisms |
| FR7520604A FR2315941A2 (en) | 1975-07-01 | 1975-07-01 | Antitumour naphthacene deriv - prepd. by redn. of carminomycin or culture of Streptomyces microorganisms |
| FR7602912A FR2340096A2 (en) | 1976-02-03 | 1976-02-03 | Antitumour naphthacene deriv - prepd. by redn. of carminomycin or culture of Streptomyces microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1510571A true GB1510571A (en) | 1978-05-10 |
Family
ID=27250421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10045/76A Expired GB1510571A (en) | 1975-03-13 | 1976-03-12 | Aminoglycosidic antibiotic |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS51115992A (en) |
| AU (1) | AU1190076A (en) |
| CA (1) | CA1068225A (en) |
| DE (1) | DE2610557A1 (en) |
| DK (1) | DK110176A (en) |
| FI (1) | FI760645A (en) |
| GB (1) | GB1510571A (en) |
| HU (1) | HU175158B (en) |
| IL (1) | IL49197A0 (en) |
| LU (1) | LU74541A1 (en) |
| NL (1) | NL7602342A (en) |
| NO (1) | NO760873L (en) |
| NZ (1) | NZ180300A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096958A (en) * | 1976-03-04 | 1978-06-27 | Stobb, Inc. | Method for handling bundles of sheets |
| IT1155446B (en) * | 1982-12-23 | 1987-01-28 | Erba Farmitalia | PROCEDURE FOR THE PURIFICATION OF ANTHRACYCLINONIC GLUCOSIDES BY SELECTIVE ADSOBMENT ON RESINS |
| JP2779652B2 (en) * | 1988-12-27 | 1998-07-23 | 武田薬品工業株式会社 | Bioactive substance TAN-1120, its reduced form, their production method and use, and microorganism |
-
1976
- 1976-03-05 NL NL7602342A patent/NL7602342A/en not_active Application Discontinuation
- 1976-03-11 AU AU11900/76A patent/AU1190076A/en not_active Expired
- 1976-03-11 IL IL49197A patent/IL49197A0/en unknown
- 1976-03-12 GB GB10045/76A patent/GB1510571A/en not_active Expired
- 1976-03-12 NO NO760873A patent/NO760873L/no unknown
- 1976-03-12 JP JP51027038A patent/JPS51115992A/en active Pending
- 1976-03-12 NZ NZ180300A patent/NZ180300A/en unknown
- 1976-03-12 HU HU76RO883A patent/HU175158B/en unknown
- 1976-03-12 DK DK110176A patent/DK110176A/en unknown
- 1976-03-12 LU LU74541A patent/LU74541A1/xx unknown
- 1976-03-12 DE DE19762610557 patent/DE2610557A1/en not_active Withdrawn
- 1976-03-12 CA CA248,335A patent/CA1068225A/en not_active Expired
- 1976-03-12 FI FI760645A patent/FI760645A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU175158B (en) | 1980-05-28 |
| DE2610557A1 (en) | 1976-09-23 |
| NL7602342A (en) | 1976-09-15 |
| LU74541A1 (en) | 1977-01-11 |
| CA1068225A (en) | 1979-12-18 |
| IL49197A0 (en) | 1976-05-31 |
| FI760645A (en) | 1976-09-14 |
| AU1190076A (en) | 1977-09-15 |
| NZ180300A (en) | 1978-07-28 |
| DK110176A (en) | 1976-09-14 |
| JPS51115992A (en) | 1976-10-13 |
| NO760873L (en) | 1976-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |