GB1503614A - Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil - Google Patents
Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracilInfo
- Publication number
- GB1503614A GB1503614A GB15282/75A GB1528275A GB1503614A GB 1503614 A GB1503614 A GB 1503614A GB 15282/75 A GB15282/75 A GB 15282/75A GB 1528275 A GB1528275 A GB 1528275A GB 1503614 A GB1503614 A GB 1503614A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluorouracil
- furanyl
- tetrahydro
- synthesizing
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WFWLQNSHRPWKFK-UHFFFAOYSA-N Tegafur Chemical compound O=C1NC(=O)C(F)=CN1C1OCCC1 WFWLQNSHRPWKFK-UHFFFAOYSA-N 0.000 title abstract 3
- 230000002194 synthesizing effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- JVCXAMPRNBMALM-UHFFFAOYSA-N 5-fluoro-3,6-bis(trimethylsilyl)-1h-pyrimidine-2,4-dione Chemical compound C[Si](C)(C)C=1NC(=O)N([Si](C)(C)C)C(=O)C=1F JVCXAMPRNBMALM-UHFFFAOYSA-N 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 230000000340 anti-metabolite Effects 0.000 abstract 1
- 229940100197 antimetabolite Drugs 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/467,538 US3960864A (en) | 1974-05-06 | 1974-05-06 | Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1503614A true GB1503614A (en) | 1978-03-15 |
Family
ID=23856104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15282/75A Expired GB1503614A (en) | 1974-05-06 | 1975-04-14 | Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil |
Country Status (14)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2648239C3 (de) * | 1975-10-24 | 1981-11-12 | Rikagaku Kenkyusho, Wako, Saitama | Di-(trialkylstannyl)-pyrimidinderivate, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Weiterverarbeitung zu nucleosidartigen Pyrimidinderivaten |
| JPS5259174A (en) * | 1975-11-10 | 1977-05-16 | Asahi Chem Ind Co Ltd | Preparation of n-substituted uracil compounds |
| IE45046B1 (en) * | 1975-11-28 | 1982-06-16 | Takeda Chemical Industries Ltd | Method of producing 5-fluorouracil derivatives |
| US4324895A (en) * | 1975-12-04 | 1982-04-13 | Rikagaku Kenkyusho | Novel process for producing pyrimidine nucleosides and novel pyrimidine nucleosides obtained thereby |
| DK142415B (da) * | 1975-12-24 | 1980-10-27 | Mitsui Toatsu Chemicals | Fremgangsmåde til fremstilling af 1-(2-tetrahydrofuryl)-5-fluoruracil. |
| CN103159746B (zh) * | 2011-12-12 | 2015-09-02 | 山东新时代药业有限公司 | 一种工业法合成替加氟的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168391A (en) * | 1968-01-08 | 1969-10-22 | Inst Organocheskogo Sinteza An | Substituted Uracils |
-
1974
- 1974-05-06 US US05/467,538 patent/US3960864A/en not_active Expired - Lifetime
-
1975
- 1975-04-02 CA CA223,644A patent/CA1024145A/en not_active Expired
- 1975-04-04 ZA ZA00752145A patent/ZA752145B/xx unknown
- 1975-04-07 IL IL47033A patent/IL47033A/xx unknown
- 1975-04-08 NO NO751217A patent/NO141993C/no unknown
- 1975-04-14 GB GB15282/75A patent/GB1503614A/en not_active Expired
- 1975-04-21 AT AT305175A patent/AT337203B/de not_active IP Right Cessation
- 1975-04-30 JP JP50053085A patent/JPS50151884A/ja active Pending
- 1975-04-30 DE DE19752519201 patent/DE2519201A1/de not_active Ceased
- 1975-05-02 CH CH564175A patent/CH610897A5/xx not_active IP Right Cessation
- 1975-05-05 DK DK197175A patent/DK137759C/da active
- 1975-05-05 FR FR7513999A patent/FR2279746A1/fr active Granted
- 1975-05-06 ES ES437481A patent/ES437481A1/es not_active Expired
- 1975-05-06 NL NL7505305A patent/NL7505305A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1024145A (en) | 1978-01-10 |
| NL7505305A (nl) | 1975-11-10 |
| NO141993C (no) | 1980-06-11 |
| JPS50151884A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-12-06 |
| DK197175A (da) | 1975-11-07 |
| AT337203B (de) | 1977-06-27 |
| ATA305175A (de) | 1976-10-15 |
| FR2279746B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-07-06 |
| DK137759B (da) | 1978-05-01 |
| FR2279746A1 (fr) | 1976-02-20 |
| CH610897A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-05-15 |
| NO141993B (no) | 1980-03-03 |
| ES437481A1 (es) | 1977-07-01 |
| ZA752145B (en) | 1976-03-31 |
| NO751217L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-11-07 |
| AU7993375A (en) | 1976-10-14 |
| IL47033A (en) | 1978-06-15 |
| DK137759C (da) | 1978-10-02 |
| IL47033A0 (en) | 1975-06-25 |
| DE2519201A1 (de) | 1975-11-20 |
| US3960864A (en) | 1976-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |