GB1502182A - Pyrimidines - Google Patents
PyrimidinesInfo
- Publication number
- GB1502182A GB1502182A GB22982/75A GB2298275A GB1502182A GB 1502182 A GB1502182 A GB 1502182A GB 22982/75 A GB22982/75 A GB 22982/75A GB 2298275 A GB2298275 A GB 2298275A GB 1502182 A GB1502182 A GB 1502182A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- morpholinopyrimidine
- dioxy
- chlorophenyl
- trioxypyrimid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- -1 PhCh 2 Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 2
- BAUWRHPMUVYFOD-UHFFFAOYSA-N 1-methylpiperidin-4-ol Chemical compound CN1CCC(O)CC1 BAUWRHPMUVYFOD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7511154A FR2306697A1 (fr) | 1975-04-10 | 1975-04-10 | Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1502182A true GB1502182A (en) | 1978-02-22 |
Family
ID=9153719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22982/75A Expired GB1502182A (en) | 1975-04-10 | 1975-05-23 | Pyrimidines |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3984411A (enExample) |
| JP (1) | JPS51118777A (enExample) |
| BE (1) | BE829845A (enExample) |
| CA (1) | CA1036597A (enExample) |
| CH (1) | CH603626A5 (enExample) |
| DE (1) | DE2528360A1 (enExample) |
| ES (1) | ES439017A1 (enExample) |
| FR (1) | FR2306697A1 (enExample) |
| GB (1) | GB1502182A (enExample) |
| IT (1) | IT1036400B (enExample) |
| LU (1) | LU72743A1 (enExample) |
| NL (1) | NL7507441A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684005A (en) * | 1988-12-07 | 1997-11-04 | Glaxo Wellcome Inc. | Pharmacologically active CNS compounds |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU176972B (hu) * | 1977-06-13 | 1981-06-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh proizvodnykh piridazinil-gidrazona |
| US4648896A (en) * | 1982-11-15 | 1987-03-10 | Ciba-Geigy Corporation | 2-aryl-4,6-dihalopyrimidines as antidote for protecting cultivated plants from phytotoxic damage caused by herbicides |
| ATE247104T1 (de) * | 1997-11-05 | 2003-08-15 | Neurosearch As | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
| ATE374766T1 (de) | 2003-01-14 | 2007-10-15 | Arena Pharm Inc | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
| JP2006518763A (ja) * | 2003-02-24 | 2006-08-17 | アリーナ ファーマシューティカルズ， インコーポレイテッド | グルコース代謝のモジュレーターとしてのフェニル−およびピリジルピペリジン誘導体 |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| CA2441775C (en) * | 2003-09-23 | 2004-09-28 | Westport Research Inc. | Container for holding a cryogenic fluid |
| WO2005121121A2 (en) * | 2004-06-04 | 2005-12-22 | Arena Pharmaceuticals, Inc. | Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| DK1931654T3 (da) * | 2005-09-16 | 2009-07-27 | Arena Pharm Inc | Stofskiftemodulatorer og behandling af lidelser relateret dertil |
| TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
| TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
| JP5657383B2 (ja) | 2007-08-30 | 2015-01-21 | ダウ アグロサイエンシィズ エルエルシー | ２−（置換フェニル）−６−アミノ−５−アルコキシ、チオアルコキシ、およびアミノアルキル−４−ピリミジンカルボキシラート、ならびに除草剤としてのそれらの使用 |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| US10934244B2 (en) | 2015-06-15 | 2021-03-02 | Nmd Pharma A/S | Compounds for use in treating neuromuscular disorders |
| PT3310760T (pt) | 2015-06-22 | 2022-11-10 | Arena Pharm Inc | Sal cristalino de l-arginina de ácido (r)-2-(7-(4-ciclopentil-3-(trifluorometil)benziloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para utilização em distúrbios associados a recetores de s1p1 |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| US11730714B2 (en) | 2017-12-14 | 2023-08-22 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US10385028B2 (en) | 2017-12-14 | 2019-08-20 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11591284B2 (en) | 2017-12-14 | 2023-02-28 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US12440477B2 (en) | 2017-12-14 | 2025-10-14 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11147788B2 (en) | 2017-12-14 | 2021-10-19 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| AU2019280822A1 (en) | 2018-06-06 | 2021-01-07 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3259623A (en) * | 1963-06-14 | 1966-07-05 | Olin Mathieson | Process for preparing 2-(secondary amino)-halogenopyrimidines |
| US3261833A (en) * | 1964-10-20 | 1966-07-19 | Smith Kline French Lab | 2,4-diamino-6-aminoalkoxy pyrimidines |
| GB1143167A (en) * | 1967-01-25 | 1969-02-19 | Ucb Sa | Derivatives of pyrimidine |
-
1975
- 1975-04-10 FR FR7511154A patent/FR2306697A1/fr active Granted
- 1975-05-23 GB GB22982/75A patent/GB1502182A/en not_active Expired
- 1975-06-04 BE BE157011A patent/BE829845A/xx not_active IP Right Cessation
- 1975-06-16 LU LU72743A patent/LU72743A1/xx unknown
- 1975-06-19 CH CH800275A patent/CH603626A5/xx not_active IP Right Cessation
- 1975-06-23 NL NL7507441A patent/NL7507441A/xx not_active Application Discontinuation
- 1975-06-25 DE DE19752528360 patent/DE2528360A1/de not_active Withdrawn
- 1975-06-27 CA CA230,309A patent/CA1036597A/fr not_active Expired
- 1975-06-30 JP JP50080752A patent/JPS51118777A/ja active Pending
- 1975-06-30 ES ES439017A patent/ES439017A1/es not_active Expired
- 1975-07-01 IT IT68679/75A patent/IT1036400B/it active
- 1975-07-17 US US05/596,880 patent/US3984411A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684005A (en) * | 1988-12-07 | 1997-11-04 | Glaxo Wellcome Inc. | Pharmacologically active CNS compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1036400B (it) | 1979-10-30 |
| CA1036597A (fr) | 1978-08-15 |
| FR2306697B1 (enExample) | 1979-08-10 |
| CH603626A5 (enExample) | 1978-08-31 |
| BE829845A (fr) | 1975-12-04 |
| US3984411A (en) | 1976-10-05 |
| DE2528360A1 (de) | 1976-10-21 |
| NL7507441A (nl) | 1976-10-12 |
| JPS51118777A (en) | 1976-10-18 |
| LU72743A1 (enExample) | 1975-10-08 |
| FR2306697A1 (fr) | 1976-11-05 |
| ES439017A1 (es) | 1977-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |